A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent

2014 ◽  
Vol 2 (32) ◽  
pp. 5295-5301 ◽  
Author(s):  
Weiren Cheng ◽  
Reshmi Rajendran ◽  
Wei Ren ◽  
Liuqun Gu ◽  
Yong Zhang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Side Effects ◽  
Contrast Agent ◽  
Self Assembly ◽  
Mri Contrast Agent ◽  
Synthetic Approach ◽  
Mri Imaging ◽  
Mri Contrast ◽  
Low Cytotoxicity

A biodegradable novel polydisulfide MRI contrast agent forming self-assembly in aqueous solution with a low cytotoxicity and a higherr1is promising for producing better MRI imaging with fewer side effects.

scholarly journals Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1235
Author(s):  
Xiaohui Nan ◽  
Wenjia Lai ◽  
Dan Li ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Magnetic Domain ◽  
Bilayer Membrane ◽  
The Body ◽  
Mri Contrast Agent ◽  
Mri Imaging ◽  
Mri Contrast

Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, and easy surface modification. These unique properties have increasingly attracted researchers to apply bacterial magnetosomes (BMs) in the fields of biology and medicine as MRI imaging contrast agents. Due to the concern of biosafety, a long-term follow-up of the distribution and clearance of BMs after entering the body is necessary. In this study, we tracked changes of BMs in major organs of mice up to 135 days after intravenous injection using a combination of several techniques. We not only confirmed the liver as the well-known targeted organs of BMs, but also found that BMs accumulated in the spleen. Besides, two major elimination paths, as well as the approximate length of time for BMs to be cleared from the mice, were revealed. Together, the results not only confirm that BMs have high biocompatibility, but also provide a long-term in-vivo assessment which may further help to forward the clinical applications of BMs as an MRI contrast agent.

Modular design of nanobody–drug conjugates for targeted-delivery of platinum anticancer drugs with an MRI contrast agent

2019 ◽  
Vol 55 (35) ◽  
pp. 5175-5178 ◽  
Author(s):  
Hai Huang ◽  
Tiantian Wu ◽  
Hongdong Shi ◽  
Yun Wu ◽  
Hongyi Yang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Modular Design ◽  
Drug Distribution ◽  
Mri Contrast Agent ◽  
Mri Imaging ◽  
Mri Contrast ◽  
Drug Conjugates ◽  
Platinum Anticancer Drugs

A multifunctional nanobody–drug conjugate was designed for the targeted-delivery of the Pt(iv) prodrug. The drug distribution can be observed by MRI imaging.

Naphthalene-facilitated self-assembly of Gd-chelate as a novel T2 MRI contrast agent for visualization of stem cell transplants

2021 ◽  
Author(s):  
Yanhui Zhang ◽  
Hailu Zhang ◽  
Dehua Huang ◽  
Bo Tan ◽  
Chengxing Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Contrast Agent ◽  
Self Assembly ◽  
Mri Contrast Agent ◽  
Peptide Sequence ◽  
Mri Contrast ◽  
L929 Cells ◽  
Cell Transplants ◽  
Stem Cell Transplants ◽  
T2 Mri

Naphthalene is coupled with DOTA via a peptide sequence to yield an amphipathic MRI probe Nap-CFGKTG-DOTA-Gd (Nap-Gd) that can self-assemble into nanofibers. Incubation of NSCs, hMSCs and L929 cells in...

Photoresponsive host–guest chemistry and relaxation time of fluorinated cyclodextrin and arylazopyrazole-functionalized DOTA metal complexes

2021 ◽  
Vol 19 (10) ◽  
pp. 2186-2191
Author(s):  
Julian Simke ◽  
Till Böckermann ◽  
Klaus Bergander ◽  
Sina Klabunde ◽  
Michael Ryan Hansen ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Relaxation Time ◽  
Contrast Agent ◽  
Metal Complexes ◽  
Mri Contrast Agent ◽  
Guest Complex ◽  
Mri Contrast ◽  
Host Guest Complex ◽  
Guest Chemistry

The photomodulation of a host–guest complex provides a new concept for a responsive 19F MRI contrast agent in aqueous solution.

Phase transfer preparation of ultrasmall MnS nanocrystals with a high performance MRI contrast agent

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 6878-6887 ◽  
Author(s):  
Jing Meng ◽  
Yizhe Zhao ◽  
Zhongfeng Li ◽  
Ligang Wang ◽  
Yang Tian
Keyword(s):  
Aqueous Solution ◽  
Contrast Agent ◽  
High Performance ◽  
Sodium Citrate ◽  
Phase Transfer ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Transfer Method ◽  
Sulfide Nanocrystals

In this paper, a phase transfer method is reported which was used to prepare ultrasmall manganese(ii) sulfide nanocrystals in which prefabricated MnS aggregations are transferred from cyclohexane into an aqueous solution of sodium citrate.

Two-photon graphene quantum dot modified Gd2O3 nanocomposites as a dual-mode MRI contrast agent and cell labelling agent

Nanoscale ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 5642-5649 ◽  
Author(s):  
F. H. Wang ◽  
K. Bae ◽  
Z. W. Huang ◽  
J. M. Xue
Keyword(s):  
Quantum Dot ◽  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Cell Labelling ◽  
Mri Imaging ◽  
Dual Mode ◽  
Mri Contrast ◽  
Graphene Quantum Dot ◽  
Two Photon ◽  
Dual Functional

Dual-functional Gd2O3/GQD nanocomposites for both photoluminescence imaging and MRI imaging.

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