A SERRS/MRI multimodal contrast agent based on naked Au nanoparticles functionalized with a Gd(iii) loaded PEG polymer for tumor imaging and localized hyperthermia

Nanoscale ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 1272-1278 ◽  
Author(s):  
Lucio Litti ◽  
Niccolò Rivato ◽  
Giulio Fracasso ◽  
Pietro Bontempi ◽  
Elena Nicolato ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Photothermal Therapy ◽  
Au Nanoparticles ◽  
Tumor Imaging ◽  
Gold Nanostructures ◽  
Agent Based

MRI and bright SERRS images are obtained with efficient gold nanostructures useful also for photothermal therapy.

An MRI contrast agent based on a zwitterionic metal-chelating polymer for hepatorenal angiography and tumor imaging

2020 ◽  
Vol 8 (31) ◽  
pp. 6956-6963
Author(s):  
Peisen Zhang ◽  
Zihua Wang ◽  
Yiyang Wang ◽  
Yuqing Wang ◽  
Chunyan Liu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Imaging ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Agent Based ◽  
Metal Chelating ◽  
Chelating Polymer

A zwitterionic MRI contrast agent Gd-PAA with exceptionally high r1 was designed for hepatorenal angiography and tumor imaging.

A novel theranostic agent based on porous bismuth nanosphere for CT imaging-guided combined chemo-photothermal therapy and radiotherapy

2018 ◽  
Vol 6 (42) ◽  
pp. 6788-6795 ◽  
Author(s):  
Guochang Ma ◽  
Xijian Liu ◽  
Guoying Deng ◽  
Haikuan Yuan ◽  
Qiugen Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Ct Imaging ◽  
Combined Chemotherapy ◽  
Agent Based ◽  
Theranostic Agent

A novel theranostic agent based on porous bismuth (pBi) nanospheres was developed for tumor imaging and combined chemotherapy, photothermal therapy and radiotherapy.

scholarly journals Laser Ablation-Assisted Synthesis of Plasmonic Si@Au Core-Satellite Nanocomposites for Biomedical Applications

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 592
Author(s):  
Ahmed Al-Kattan ◽  
Gleb Tselikov ◽  
Khaled Metwally ◽  
Anton A. Popov ◽  
Serge Mensah ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Au Nanoparticles ◽  
Complex Geometry ◽  
Mie Theory ◽  
Volume Ratio ◽  
Gold Nanostructures ◽  
Absorption Feature ◽  
Au Nps

Owing to strong plasmonic absorption and excellent biocompatibility, gold nanostructures are among best candidates for photoacoustic bioimaging and photothermal therapy, but such applications require ultrapure Au-based nanoformulations of complex geometry (core-shells, nanorods) in order to shift the absorption band toward the region of relative tissue transparency (650–1000 nm). Here, we present a methodology for the fabrication of Si@Au core-satellite nanostructures, comprising of a Si core covered with small Au nanoparticles (NP), based on laser ablative synthesis of Si and Au NPs in water/ethanol solutions, followed by a chemical modification of the Si NPs by 3-aminopropyltrimethoxysilane (APTMS) and their subsequent decoration by the Au NPs. We show that the formed core-satellites have a red-shifted plasmonic absorption feature compared to that of pure Au NPs (520 nm), with the position of the peak depending on APTMS amount, water−ethanol solvent percentage and Si−Au volume ratio. As an example, even relatively small 40-nm core-satellites (34 nm Si core + 4 nm Au shell) provided a much red shifted peak centered around 610 nm and having a large tail over 700 nm. The generation of the plasmonic peak is confirmed by modeling of Si@Au core-shells of relevant parameters via Mie theory. Being relatively small and exempt of any toxic impurity due to ultraclean laser synthesis, the Si@Au core-satellites promise a major advancement of imaging and phototherapy modalities based on plasmonic properties of nanomaterials.

Hypoxia-targeting dendritic MRI contrast agent based on internally hydroxy dendrimer for tumor imaging

Biomaterials ◽  
2019 ◽  
Vol 213 ◽  
pp. 119195 ◽  
Author(s):  
Yuxin Han ◽  
Xiaoxuan Zhou ◽  
Yue Qian ◽  
Hongjie Hu ◽  
Zhuxian Zhou ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Tumor Imaging ◽  
Mri Contrast Agent ◽  
Mri Contrast ◽  
Agent Based

scholarly journals Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Matias Luis Picchio ◽  
Julian Bergueiro Álvarez ◽  
Stefanie Wedepohl ◽  
Roque J Minari ◽  
Cecilia Ines Alvarez Igarzabal ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Contrast Agent ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Hydrophobic Protein ◽  
Nir Dyes ◽  
Protein Pockets ◽  
J Aggregates ◽  
Innovative Concept

After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR...

scholarly journals A study on the imaging characteristics of Gold nanoparticles as a contrast agent in X-ray computed tomography

2017 ◽  
Vol 23 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Asghar Mesbahi ◽  
Fatemeh Famouri ◽  
Mohammad Johari Ahar ◽  
Maryam Olade Ghaffari ◽  
Seyed Mostafa Ghavami
Keyword(s):  
Computed Tomography ◽  
Contrast Media ◽  
Contrast Agent ◽  
Hounsfield Unit ◽  
Ct Number ◽  
Agent Based ◽  
X Ray ◽  
Imaging Characteristics ◽  
Tube Potential ◽  
X Ray Computed

AbstractAim: In the current study, some imaging characteristics of AuNPs were quantitatively analyzed and compared with two conventional contrast media (CM) including Iodine and Gadolinium by using of a cylindrical phantom.Methods: AuNPs were synthesized with the mean diameter of 16 nm and were equalized to the concentration of 0.5, 1, 2 and 4 mg/mL in the same volumes. A cylindrical phantom resembling the head and neck was fabricated and drilled to contain small tubes filled with Iodine, Gadolinium, and AuNPs as contrast media. The phantom was scanned in different exposure techniques and CT numbers of three studied contrast media inside test tubes were measured in terms of Hounsfield Unit (HU). The imaging parameters of the noise and contrast to noise ratios (CNR) were calculated for all studied CMs.Results: AuNPs showed 128% and 166% higher CT number in comparison with Iodine and Gadolinium respectively. Also, Iodine had a greater CT number than Gadolinium for the same exposure techniques and concentration. The maximum CT number for AuNPs and studied contrast materials was obtained at the highest mAs and the lowest tube potential. The maximum CT number were 1033±11 (HU) for AuNP, 565±10 (HU) for Iodine, 458±11 for Gadolinium. Moreover, the maximum CNRs of 433±117, 203±53, 145±37 were found for AuNPs, Iodine and Gadolinium respectively.Conclusion: The contrast agent based on AuNPs showed higher imaging quality in terms of contrast and noise relative to other iodine and gadolinium based contrast media in X-ray computed tomography. Application of the AuNPs as a contrast medium in x-ray CT is recommended.

scholarly journals Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH+ Cancer Cells in MRI

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Milad Yousefvand ◽  
Zahra Mohammadi ◽  
Farzaneh Ghorbani ◽  
Rasoul Irajirad ◽  
Hormoz Abedi ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Tumor Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Gnrh Receptors ◽  
Imaging Probes ◽  
Magnetic Resonance Imaging Mri ◽  
Targeted Contrast Agent

In recent years, the conjugation of superparamagnetic iron oxide nanoparticles (SPIONs), as tumor-imaging probes for magnetic resonance imaging (MRI), with tumor targeting peptides possesses promising advantages for specific delivery of MRI agents. The objective of the current study was to design a targeted contrast agent for MRI based on Fe3O4 nanoparticles conjugated triptorelin (SPION@triptorelin), which has a great affinity to the GnRH receptors. The SPIONs-coated carboxymethyl dextran (SPION@CMD) conjugated triptorelin (SPION@CMD@triptorelin) were synthesized using coprecipitation method and characterized by DLS, TEM, XRD, FTIR, Zeta, and VSM techniques. The relaxivities of synthetized formulations were then calculated using a 1.5 Tesla clinical magnetic field. MRI, quantitative cellular uptake, and cytotoxicity level of them were estimated. The characterization results confirmed that the formation of SPION@CMD@triptorelin has been conjugated with a suitable size. Our results demonstrated the lack of cellular cytotoxicity of SPION@CMD@triptorelin, and it could increase the cellular uptake of SPIONs to MDA-MB-231 cancer cells 6.50-fold greater than to SPION@CMD at the concentration of 75 μM. The relaxivity calculations for SPION@CMD@triptorelin showed a suitable r2 and r2/r1 with values of 31.75 mM−1·s−1 and 10.26, respectively. Our findings confirm that triptorelin-targeted SPIONs could provide a T2-weighted probe contrast agent that has the great potential for the diagnosis of GnRH-positive cancer in MRI.

Polypyrrole-encapsulated iron tungstate nanocomposites: a versatile platform for multimodal tumor imaging and photothermal therapy

Nanoscale ◽  
2016 ◽  
Vol 8 (26) ◽  
pp. 12917-12928 ◽  
Author(s):  
Zhiyin Xiao ◽  
Chen Peng ◽  
Xiaohong Jiang ◽  
Yuxuan Peng ◽  
Xiaojuan Huang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Imaging

Glutathione-Responsive Self-Assembled Magnetic Gold Nanowreath for Enhanced Tumor Imaging and Imaging-Guided Photothermal Therapy

ACS Nano ◽  
2018 ◽  
Vol 12 (8) ◽  
pp. 8129-8137 ◽  
Author(s):  
Yijing Liu ◽  
Zhen Yang ◽  
Xiaolin Huang ◽  
Guocan Yu ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Tumor Imaging ◽  
Self Assembled
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