scholarly journals Near infrared dye-labelled polymeric micro- and nanomaterials:in vivoimaging and evaluation of their local persistence

Nanoscale ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 2970-2982 ◽  
Author(s):  
Gracia Mendoza ◽  
Isabel Ortiz de Solorzano ◽  
Inmaculada Pintre ◽  
Sara Garcia-Salinas ◽  
Victor Sebastian ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Near Infrared ◽  
Polymeric Materials ◽  
Drug Carriers ◽  
Preclinical Imaging ◽  
Near Infrared Dye

NIR labelling of polymeric materials by chemical modification has been achieved to obtain biocompatible drug carriers for preclinical imaging.

Surface Modification of Poly(Vinylchloride) for Manufacturing Advanced Catheters

2020 ◽  
Vol 27 (10) ◽  
pp. 1616-1633 ◽  
Author(s):  
Oana Cristina Duta ◽  
Aurel Mihail Ţîţu ◽  
Alexandru Marin ◽  
Anton Ficai ◽  
Denisa Ficai ◽  
...  
Keyword(s):  
Surface Modification ◽  
Chemical Modification ◽  
Medical Devices ◽  
Low Cost ◽  
Physical And Mechanical Properties ◽  
Polymeric Materials ◽  
Modern Medicine ◽  
Structural Failure ◽  
Chemical Grafting ◽  
One Step

Polymeric materials, due to their excellent physicochemical properties and versatility found applicability in multiples areas, including biomaterials used in tissue regeneration, prosthetics (hip, artificial valves), medical devices, controlled drug delivery systems, etc. Medical devices and their applications are very important in modern medicine and the need to develop new materials with improved properties or to improve the existent materials is increasing every day. Numerous reasearches are activated in this domain in order to obtain materials/surfaces that does not have drawbacks such as structural failure, calcifications, infections or thrombosis. One of the most used material is poly(vinylchloride) (PVC) due to its unique properties, availability and low cost. The most common method used for obtaining tubular devices that meet the requirements of medical use is the surface modification of polymers without changing their physical and mechanical properties, in bulk. PVC is a hydrophobic polymer and therefore many research studies were conducted in order to increase the hydrophilicity of the surface by chemical modification in order to improve biocompatibility, to enhance wettability, reduce friction or to make lubricious or antimicrobial coatings. Surface modification of PVC can be achieved by several strategies, in only one step or, in some cases, in two or more steps by applying several techniques consecutively to obtain the desired modification / performances. The most common processes used for modifying the surface of PVC devices are: plasma treatment, corona discharge, chemical grafting, electric discharge, vapour deposition of metals, flame treatment, direct chemical modification (oxidation, hydrolysis, etc.) or even some physical modification of the roughness of the surface.

Exciton Dynamics in J- and H-Aggregates of a Tricarbocyanine Near-Infrared Dye

2021 ◽  
Author(s):  
Oleg P. Dimitriev ◽  
Johannes Zirzlmeier ◽  
Arjun Menon ◽  
Yuri Slominskii ◽  
Dirk M. Guldi
Keyword(s):  
Near Infrared ◽  
Exciton Dynamics ◽  
Near Infrared Dye

scholarly journals SGM-101: An innovative near-infrared dye-antibody conjugate that targets CEA for fluorescence-guided surgery

2017 ◽  
Vol 26 (2) ◽  
pp. 153-162 ◽  
Author(s):  
Marian Gutowski ◽  
Bérénice Framery ◽  
Martin C. Boonstra ◽  
Véronique Garambois ◽  
François Quenet ◽  
...  
Keyword(s):  
Near Infrared ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Antibody Conjugate ◽  
Near Infrared Dye

Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging

2016 ◽  
Vol 4 (48) ◽  
pp. 7845-7851 ◽  
Author(s):  
Junpeng Shi ◽  
Meng Sun ◽  
Xia Sun ◽  
Hongwu Zhang
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
High Sensitivity ◽  
Drug Carriers ◽  
Template Method ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Large Capacity

Near-infrared persistent luminescence hollow mesoporous nanospheres have been synthesized via a template method. These nanospheres can be used as large capacity drug carriers and realize super long-term and high sensitivity tracking of drug delivery in deep tissue.

Synthesis of NIR-emitting O-chelated BODIPYs fused with benzene and acenaphthylene

2014 ◽  
Vol 18 (08n09) ◽  
pp. 752-761 ◽  
Author(s):  
Tetsuo Okujima ◽  
Yoichi Shida ◽  
Keishi Ohara ◽  
Yuya Tomimori ◽  
Motoyoshi Nishioka ◽  
...  
Keyword(s):  
Near Infrared ◽  
Photophysical Properties ◽  
Fluorescence Emission ◽  
Fluorescence Measurement ◽  
Aromatic Rings ◽  
Nir Absorption ◽  
Intense Absorption ◽  
Near Infrared Dye

A series of O-chelated BODIPYs fused with aromatic rings such as benzene and acenaphthylene at β,β-positions was synthesized as a near-infrared dye. The photophysical properties were examined by UV-vis-NIR absorption and fluorescence measurement. Acenaphthylene-fused O-BODIPYs showed a intense absorption at 750–840 nm with the ε of 105 M-1.cm-1. and a fluorescence emission at 770–850 nm with the high Φ value of 0.06–0.43.

A near-infrared dye based on BODIPY for tracking morphology changes in mitochondria

2013 ◽  
Vol 49 (90) ◽  
pp. 10620 ◽  
Author(s):  
Na Jiang ◽  
Jiangli Fan ◽  
Tao Liu ◽  
Jianfang Cao ◽  
Bo Qiao ◽  
...  
Keyword(s):  
Near Infrared ◽  
Near Infrared Dye ◽  
Morphology Changes

scholarly journals Supercritical carbon dioxide design strategies: from drug carriers to soft killers

2015 ◽  
Vol 373 (2057) ◽  
pp. 20150009 ◽  
Author(s):  
Ana Aguiar-Ricardo ◽  
Vasco D. B. Bonifácio ◽  
Teresa Casimiro ◽  
Vanessa G. Correia
Keyword(s):  
Carbon Dioxide ◽  
Supercritical Carbon Dioxide ◽  
Three Dimensional ◽  
Polymeric Materials ◽  
Drug Carriers ◽  
Water Soluble ◽  
Materials Processing ◽  
Design Strategies ◽  
Simple Economic ◽  
Supercritical Carbon

The integrated use of supercritical carbon dioxide (scCO 2 ) and micro- and nanotechnologies has enabled new sustainable strategies for the manufacturing of new medications. ‘Green’ scCO 2 -based methodologies are well suited to improve either the synthesis or materials processing leading to the assembly of three-dimensional multifunctional constructs. By using scCO 2 either as C1 feedstock or as solvent, simple, economic, efficient and clean routes can be designed to synthesize materials with unique properties such as polyurea dendrimers and oxazoline-based polymers/oligomers. These new biocompatible, biodegradable and water-soluble polymeric materials can be engineered into multifunctional constructs with antimicrobial activity, targeting moieties, labelling units and/or efficiently loaded with therapeutics. This mini-review highlights the particular features exhibited by these materials resulting directly from the followed supercritical routes.

scholarly journals Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation

2021 ◽  
Author(s):  
WEN-SHUO KUO ◽  
Chia-Yuan Chang ◽  
Ping-Ching Wu ◽  
Jiu-Yao Wang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Chemical Modification ◽  
Near Infrared ◽  
Photon Absorption ◽  
Excitation Wavelength ◽  
Strong Electron ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Abstract BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. ConclusionThe sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.

scholarly journals Optimization and functionalization of red-shifted rhodamine dyes

2019 ◽  
Author(s):  
Jonathan B. Grimm ◽  
Ariana N. Tkachuk ◽  
Heejun Choi ◽  
Boaz Mohar ◽  
Natalie Falco ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Near Infrared ◽  
Fluorescent Dyes ◽  
Poor Performance ◽  
Biological Imaging ◽  
Infrared Light ◽  
Long Wavelength ◽  
General Chemical ◽  
Chemical Groups ◽  
Rhodamine Dyes

ABSTRACTExpanding the palette of fluorescent dyes is vital for pushing the frontier of biological imaging. Although rhodamine dyes remain the premier type of small-molecule fluorophore due to their bioavailability and brightness, variants excited with far-red or near-infrared light suffer from poor performance due to their propensity to adopt a lipophilic, nonfluorescent form. We report a general chemical modification for rhodamines that optimizes long-wavelength variants and enables facile functionalization with different chemical groups.

Highly stable near-infrared dye conjugated cerasomes for fluorescence imaging-guided synergistic chemo-photothermal therapy of colorectal cancer

2019 ◽  
Vol 7 (7) ◽  
pp. 2873-2888 ◽  
Author(s):  
Xu Zhang ◽  
Xiaolong Liang ◽  
Xiaotu Ma ◽  
Rui Hou ◽  
Xiaoda Li ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Release ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
High Stability ◽  
Near Infrared ◽  
Great Promise ◽  
Near Infrared Dye

Dye-conjugated cerasome loaded with DOX exhibited high stability and controllable drug release, holding great promise in colorectal cancer photothermal chemotherapy.

Sign in / Sign up

Export Citation Format

Share Document