Multivalent mesoporous silica nanoparticles photo-delivering nitric oxide with carbon dots as fluorescence reporters

Nanoscale ◽  
2017 ◽  
Vol 9 (36) ◽  
pp. 13404-13408 ◽  
Author(s):  
Damien Afonso ◽  
Sabrina Valetti ◽  
Aurore Fraix ◽  
Claudia Bascetta ◽  
Salvatore Petralia ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Carbon Dots ◽  
Mesoporous Silica Nanoparticles ◽  
Light Control

Mesoporous silica nanoparticles release NO under light control and exploit the embedded carbon dots as fluorescence reporters for the NO liberated.

Fluorophore-free luminescent double-shelled hollow mesoporous silica nanoparticles as pesticide delivery vehicles

Nanoscale ◽  
2018 ◽  
Vol 10 (43) ◽  
pp. 20354-20365 ◽  
Author(s):  
Lidong Cao ◽  
Huirong Zhang ◽  
Zhaolu Zhou ◽  
Chunli Xu ◽  
Yongpan Shan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Carbon Dots ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Vehicles ◽  
Hollow Mesoporous Silica

Carbon dots-embedded hollow double-shelled mesoporous silica nanoparticles serve as pesticide delivery vehicles.

Dual-responsive mesoporous silica nanoparticles coated with carbon dots and polymers for drug encapsulation and delivery

Nanomedicine ◽  
2020 ◽  
Vol 15 (25) ◽  
pp. 2447-2458
Author(s):  
Xiaona Li ◽  
Shun Hu ◽  
Zhe Lin ◽  
Jie Yi ◽  
Xue Liu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Real Time ◽  
Fluorescence Intensity ◽  
Carbon Dots ◽  
Mesoporous Silica Nanoparticles ◽  
Aldehyde Group ◽  
Real Time Monitoring ◽  
Dual Responsive

Aim: Smart mesoporous silica nanoparticles (MSNs) coated with carbon dots (CDs) and poly(N-vinylcaprolactam) (PNVCL) as a mixed shell (CDs/PNVCL polymer grafted MSNs) were prepared for pH-trigged anticancer drug release and real-time monitoring. Materials & methods: The amino-terminated PNVCL and amino-rich CDs were grafted onto the surface of aldehyde group functionalized MSNs through Schiff base reaction. Doxorubicin (DOX) was loaded into the prepared nanoparticles. Results: DOX could be quickly released in the tumor environment, leading to cell apoptosis. The linear fit between the percentage of released DOX and the fluorescence intensity of CDs indicated that the change in fluorescence intensity could be used to monitor drug release in real time. Conclusion: The as-prepared CDs/PNVCL polymer grafted MSNs are promising candidates for integrating controllable release and real-time monitoring in cancer treatment.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity

2021 ◽  
Vol 119 ◽  
pp. 111619
Author(s):  
Paul Jänicke ◽  
Claudia Lennicke ◽  
Annette Meister ◽  
Barbara Seliger ◽  
Ludger A. Wessjohann ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Anticancer Activity ◽  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Mesoporous Silica Nanoparticles
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