Fluorophore-free luminescent double-shelled hollow mesoporous silica nanoparticles as pesticide delivery vehicles

Nanoscale ◽  
2018 ◽  
Vol 10 (43) ◽  
pp. 20354-20365 ◽  
Author(s):  
Lidong Cao ◽  
Huirong Zhang ◽  
Zhaolu Zhou ◽  
Chunli Xu ◽  
Yongpan Shan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Carbon Dots ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Vehicles ◽  
Hollow Mesoporous Silica

Carbon dots-embedded hollow double-shelled mesoporous silica nanoparticles serve as pesticide delivery vehicles.

scholarly journals Polymeric Mesoporous Silica Nanoparticles for Enhanced Delivery of 5-Fluorouracil In Vitro

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 288 ◽  
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Side Effects ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Therapeutic Potential ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Hek293 Cells ◽  
Cancer Drug ◽  
Delivery Vehicles

There is a need for the improvement of conventional cancer treatment strategies by incorporation of targeted and non-invasive procedures aimed to reduce side-effects, drug resistance, and recurrent metastases. The anti-cancer drug, 5-fluorouracil (5-FU), is linked to a variety of induced-systemic toxicities due to its lack of specificity and potent administration regimens, necessitating the development of delivery vehicles that can enhance its therapeutic potential, while minimizing associated side-effects. Polymeric mesoporous silica nanoparticles (MSNs) have gained popularity as delivery vehicles due to their high loading capacities, biocompatibility, and good pharmacokinetics. MSNs produced in this study were functionalized with the biocompatible polymers, chitosan, and poly(ethylene)glycol to produce monodisperse NPs of 36–65 nm, with a large surface area of 710.36 m2/g, large pore volume, diameter spanning 9.8 nm, and a favorable zeta potential allowing for stability and enhanced uptake of 5-FU. Significant drug loading (0.15–0.18 mg5FU/mgmsn), controlled release profiles (15–65%) over 72 hours, and cell specific cytotoxicity in cancer cells (Caco-2, MCF-7, and HeLa) with reduced cell viability (≥50%) over the non-cancer (HEK293) cells were established. Overall, these 5FU-MSN formulations have been shown to be safe and effective delivery systems in vitro, with potential for in vivo applications.

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

NIR-absorbing dye functionalized hollow mesoporous silica nanoparticles for combined photothermal–chemotherapy

2017 ◽  
Vol 53 (88) ◽  
pp. 12032-12035 ◽  
Author(s):  
Yuanyuan Zhang ◽  
Qiuyu Qu ◽  
Xiang Cao ◽  
Yanli Zhao
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Anticancer Efficacy ◽  
Hollow Mesoporous Silica ◽  
Multifunctional Nanocarriers

Multifunctional nanocarriers consisting of hollow mesoporous silica nanoparticles loaded with doxorubicin and then capped by a complex between disulfide linked β-cyclodextrin and adamantane functionalized indocyanine dye are developed for improved anticancer efficacy through combined photothermal–chemotherapy.

scholarly journals Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles

2018 ◽  
Author(s):  
Wei Chen ◽  
ChiAn Cheng ◽  
Emily Cosco ◽  
Shyam Ramakrishnan ◽  
Jakob Lingg ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Contrast Agents ◽  
Silica Nanoparticles ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
J Aggregates ◽  
Hollow Mesoporous Silica ◽  
Shortwave Infrared

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-aggregation offers a means to transform stable, near-infrared (NIR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that hollow mesoporous silica nanoparticles (HMSNs) can template the J-aggregation of NIR fluorophore IR-140 to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging <i>in vivo</i>with 980 nm excitation.

Facile Synthesis of Well-dispersed Hollow Mesoporous Silica Nanoparticles Using Iron Oxide Nanoparticles as Template

2013 ◽  
Vol 42 (3) ◽  
pp. 316-317 ◽  
Author(s):  
Takaaki Ikuno ◽  
Atsuro Nomura ◽  
Kenta Iyoki ◽  
Ayae Sugawara-Narutaki ◽  
Tatsuya Okubo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Hollow Mesoporous Silica

scholarly journals Synthesis and Characterization of Hollow Mesoporous Silica Nanoparticles for Smart Corrosion Protection

Nanomaterials ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 478 ◽  
Author(s):  
Cristina Zea ◽  
Jenifer Alcántara ◽  
Rosa Barranco-García ◽  
Manuel Morcillo ◽  
Daniel de la Fuente
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Corrosion Protection ◽  
Mesoporous Silica Nanoparticles ◽  
Synthesis And Characterization ◽  
Hollow Mesoporous Silica
Sign in / Sign up

Export Citation Format

Share Document