Biomimetic nanofibers can construct effective tissue-engineered intervertebral discs for therapeutic implantation

Nanoscale ◽  
2017 ◽  
Vol 9 (35) ◽  
pp. 13095-13103 ◽  
Author(s):  
Junchuan Yang ◽  
Xinglong Yang ◽  
Le Wang ◽  
Wei Zhang ◽  
Wenbo Yu ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Intervertebral Discs ◽  
Novel Approach ◽  
Biomimetic Nanofibers

We developed a tissue engineered intervertebral disc (TE-IVD) based on biomimetic electrospun PCL/PLGA/Collagen nanofibers to address IVD degradation. Our study provides a novel approach for constructing TE-IVD.

Melatonin: Protection of the Intervertebral Disc

2019 ◽  
Vol 2 (3) ◽  
pp. 1-9
Author(s):  
Russel J Reiter ◽  
Sergio Rosales-Corral ◽  
Ramaswamy Sharma
Keyword(s):  
Intervertebral Disc ◽  
Molecular Mechanisms ◽  
Intervertebral Discs ◽  
Lumbar Pain ◽  
Low Back ◽  
Work Time ◽  
Protective Actions ◽  
Aging Populations ◽  
Definition Of ◽  
Endogenous Melatonin

     Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies.  The loss of work time as a result of this problem is massive.  Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actions. 

EXPERIENCE OF CONSERVATIVE TREATMENT OF INTERVERTEBRAL DISC HERNIAS WITH CARIFLEX GEL AND CREAM IN AMBULATORY CONDITIONS

2020 ◽  
Vol 3 (1) ◽  
pp. 6-8
Author(s):  
Zufar ADAMBAEV ◽  
◽  
Ibodulla KILICHEV ◽  
Tuygunoy XODJANOVA
Keyword(s):  
Comparative Analysis ◽  
Conservative Treatment ◽  
Intervertebral Disc ◽  
Range Of Motion ◽  
Comparative Evaluation ◽  
Intervertebral Discs ◽  
Neurological Manifestations ◽  
Complex Therapy

A complex therapy of patients with degenerative-dystrophic diseases of the spine with herniated intervertebral discs with neurological manifestations was carried out with the addition of phonophoresis Kariflex gel followed by segmental massage with Kariflex cream. The comparative evaluation of the method was carried out in 89 patients. Comparative analysis revealed the reliable efficiency of the method used. Against the background of the proposed therapy, there was a significant decrease in pain and muscle-tonic syndromes, an increase in the range of motion in the spine

Treatment of protruded lumbar intervertebral discs with chymopapain (Discase)

1973 ◽  
Vol 39 (2) ◽  
pp. 203-208 ◽  
Author(s):  
Dwight Parkinson ◽  
Christopher Shields
Keyword(s):  
Intervertebral Disc ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Intervertebral Discs ◽  
Intervertebral Disc Disease ◽  
Disc Disease ◽  
Chemical Action ◽  
Content Type ◽  
Fine Print

✓ Thirty-three intervertebral disc patients who otherwise would have been subjected to surgery were treated by injection with chymopapain. The pharmacology, toxicology, physiology, immunology, and chemical action of this enzyme, which specifically reacts with chondromucoproteins, are discussed. Results indicate that this method, although still experimental and unapproved by the U. S. Food and Drug Administration, may become a useful addition to the surgeon's armamentarium in the treatment of intervertebral disc disease.

scholarly journals Early differentation of lamellar structure of the intervertebral disc in staged human embryos

2015 ◽  
Vol 84 (3) ◽  
pp. 157-166
Author(s):  
Witold Woźniak ◽  
Małgorzata Grzymisławska ◽  
Joanna Łupicka ◽  
Małgorzata Bruska ◽  
Adam Piotrowski ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Nucleus Pulposus ◽  
Annulus Fibrosus ◽  
Developmental Stages ◽  
Intervertebral Discs ◽  
Human Embryos ◽  
Lateral Zone ◽  
Vast Literature ◽  
Dense Zone

Introduction. In the vast literature concerning the development of the intervertebral discs controversies exist as to the period of differentiation and structure of the nucleus pulposus and annulus fibrosus. These controversies result from different determination of age of the investigated embryos. Aim. Using embryos from departmental collection age of which was established according to international Carnegie staging and expressed in postfertilizational days, the differentiation of the intervertebral discs was traced. Material and methods. Study was performed on 34 embryos at developmental stages 13–23 (32–56 days). Embryos were serially sectioned in sagittal, frontal and horizontal planes. Sections were stained with various histological methods and impregnated with silver.Results. Division of sclerotomes into loose cranial and dense caudal zones (sclerotomites) was observed in embryos aged 32 days (stage 13). The intervertebral disc developed from the dense zone of sclerotome and was well recognized in embryos aged 33 days (stage 14). At the end of fifth week (embryos at stage 15, 36 days) the annulus fibrosus and the nucleus pulposus were seen. The annulus fibrosus differentiated into lateral and medial zones. Within the lateral zone cells were arranged into circular rows. These rows were considered as the first stage of laminar structure. In further developmental stages the laminae occupied both zones of the annulus fibrosus.Conclusions. The intervertebral discs develop from the dense zone of the sclerotome which is evident in embryos at stage 13 (32 days). Discs differentiate in embryos aged 33 days, when the nucleus pulposus and annulus fibrosus are recognized. In embryos aged 36 days in the annulus fibrosus circular rows forming laminar arrangement are seen.

Effects of Swelling Conditions on the Compressive Properties of Nucleus Pulposus From Bovine Intervertebral Discs

2004 ◽  
Author(s):  
David T. Korda ◽  
Delphine Perie ◽  
James C. Iatridis
Keyword(s):  
Intervertebral Disc ◽  
Water Content ◽  
Nucleus Pulposus ◽  
Annulus Fibrosus ◽  
Compressive Loading ◽  
Collagen Matrix ◽  
High Water ◽  
Intervertebral Discs ◽  
High Water Content ◽  
Outer Annulus Fibrosus

The intervertebral disc provides flexibility and load support for the spine. It consists of two main regions; the outer annulus fibrosus which is a highly organized collagen matrix and the inner nucleus pulposus which (in a healthy disc) is a proteoglycan rich gelatinous material. The predominant mode of loading on the intervertebral disc is axial compression, which generates hydrostatic pressures within the disc. The high water content of the nucleus plays a major role in supporting these loads. With age and degeneration, the water content of the nucleus changes, and is believed to significantly impact its ability to bear load. The purpose of this study therefore, was to define the effects of swelling conditions (which affect disc hydration) on the material properties of the disc under compressive loading.

Introduction of Disc Material into the Vertebral Canal by Fenestration of Thoracolumbar Discs Following Decompressive Surgery

2019 ◽  
Vol 33 (01) ◽  
pp. 066-070
Author(s):  
Georgina Harris ◽  
Paul Freeman
Keyword(s):  
Intervertebral Disc ◽  
Intervertebral Discs ◽  
Decompressive Surgery ◽  
Common Disease ◽  
Additional Material ◽  
Vertebral Canal ◽  
Disc Material ◽  
Before And After ◽  
Preliminary Study ◽  
Disc Extrusion

Abstract Objective Intervertebral disc extrusion is a common disease affecting chondrodystrophic dogs. It has been reported that fenestration of thoracolumbar intervertebral discs reduces recurrence of disc extrusion and is associated with a low complication rate. One complication reported is iatrogenic introduction of disc material into the canal directly following fenestration. This study aimed to ascertain if, and at what frequency, additional disc material may be introduced into the vertebral canal by fenestration of the affected disc following decompressive surgery. Study Design Twenty-one dogs that underwent hemilaminectomy and disc fenestration for the treatment of thoracolumbar intervertebral disc extrusion had intraoperative assessment of the vertebral canal before and after fenestration. The spinal cord was first decompressed by hemilaminectomy and removal of all visible extruded disc material within the vertebral canal. Once no further material was visible, manual fenestration of the affected disc was performed. The vertebral canal was re-inspected, and the presence or absence of additional material was noted and included in the surgery report. Results Seven dogs showed the presence of new disc material in the vertebral canal post fenestration.This preliminary study shows that additional disc material can be forced into the vertebral canal by fenestration following decompressive surgery, with a frequency of 7/21. Conclusion This illustrates the importance of checking the vertebral canal after fenestration of an extruded intervertebral disc.

T9-T10 Intervertebral Disc Herniation in Three Dogs

1996 ◽  
Vol 09 (04) ◽  
pp. 177-178 ◽  
Author(s):  
R. Selcer ◽  
W. H. Adams ◽  
W. B. Thomas ◽  
B. E. Wilkens
Keyword(s):  
Spinal Cord ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Intervertebral Discs ◽  
Postmortem Examination ◽  
Intervertebral Disc Herniation ◽  
Lumbar Region ◽  
Pain Sensation ◽  
Thoracolumbar Region ◽  
Disc Material

SummaryThree middle-aged (6-8 years), intact male Dachshunds were admitted to the University of Tennessee Veterinary Teaching Hospital (UTVTH) with acute onset of back pain and pelvic limb paralysis.Physical examination of dog #1 revealed hyperaesthesia of the thoracolumbar spine. Superficial pain sensation was absent in the pelvic limbs, while deep pain sensation was intact. The cutaneous trunci (panniculus) reflex was absent caudal to the thoraco-lumbar region. Reflexes to the pelvic limbs were exaggerated.A myelogram showed dorsal deviation of the ventral contrast column and attenuation of the ventral and dorsal contrast columns at the T9-T10 disc space. A hemilaminectomy was performed from T9 to T10, and mineralized disc material was retrieved from the vertebral canal at T9-T10. The T9- T10 to L3-L4 disc spaces were fenestrated. Two weeks after surgery, superficial and deep pain sensation of the rearlimbs were present, but paralysis persisted. The animal was euthanatised at the owners’ request. A postmortem examination was not performed.Dog #2 displayed absent superficial pain sensation, and intact deep pain sensation of the pelvic limbs. Hyperaesthesia of the thoracolumbar region and hyperreflexia of the rear limbs were noted. Examination of the cutaneous trunci reflex was not performed. A myelogram revealed ventral extradural compression of the spinal cord at T9- T10. A T9-T10 hemilaminectomy revealed a large amount of extruded disc material, which was removed. The Tll- T12 to L4-L5 intervertebral discs were fenestrated. Forty-eight hours postoperatively, the patient regained voluntary motor function, and recovery was uneventful.Neurologic examination of dog #3 revealed absence of deep pain sensation in the pelvic limbs; duration of which was not known. Spinal radiographs and myelography revealed ventral extradural spinal cord compression at T9-T10 (Fig.). A right-sided hemilaminectomy at T9-T10 revealed a large amount of calcified disc material, ventral to the spinal cord. The T11-T12 through Ll- L2 intervertebral discs were fenestrated. Sixty days postoperatively, paralysis persisted and the dog was euthanatised. No postmortem examination was performed.Herniation of the T9-T10 intervertebral disc was diagnosed in three Dachshunds with acute paraplegia. The clinical diagnosis and surgical management of T9-T10 disc herniation are similar to that in the more common sites of disc herniation.

P142. Disc collapse following discectomy using a novel approach to measure intervertebral disc height

2005 ◽  
Vol 5 (4) ◽  
pp. S178
Author(s):  
Emir Kamaric ◽  
Milorad Vilandecic ◽  
Oscar Yeh ◽  
Almir Velagic ◽  
Jacob Einhorn ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Disc Height ◽  
Novel Approach ◽  
Intervertebral Disc Height

Nucleus Implant Parameters Significantly Change the Compressive Stiffness of the Human Lumbar Intervertebral Disc

2005 ◽  
Vol 127 (3) ◽  
pp. 536-540 ◽  
Author(s):  
Abhijeet Joshi ◽  
Samir Mehta ◽  
Edward Vresilovic ◽  
Andrew Karduna ◽  
Michele Marcolongo
Keyword(s):  
Back Pain ◽  
Intervertebral Disc ◽  
Lower Back Pain ◽  
Recent Trend ◽  
Intervertebral Discs ◽  
Geometric Parameters ◽  
Synthetic Material ◽  
Lumbar Intervertebral Disc ◽  
Compressive Stiffness ◽  
Lower Back

Nucleus replacement by a synthetic material is a recent trend for treatment of lower back pain. Hydrogel nucleus implants were prepared with variations in implant modulus, height, and diameter. Human lumbar intervertebral discs (IVDs) were tested in compression for intact, denucleated, and implanted condition. Implantation of nucleus implants with different material and geometric parameters into a denucleated IVD significantly altered the IVD compressive stiffness. Variations in the nucleus implant parameters significantly change the compressive stiffness of the human lumbar IVD. Implant geometrical variations were more effective than those of implant modulus variations in the range examined.

scholarly journals Two-year observation of artificial intervertebral disc replacement: results after supplemental ultra—high strength bioresorbable spinal stabilization

2004 ◽  
Vol 100 (4) ◽  
pp. 337-342 ◽  
Author(s):  
Yoshihisa Kotani ◽  
Kuniyoshi Abumi ◽  
Yasuo Shikinami ◽  
Masahiko Takahata ◽  
Ken Kadoya ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Bone Ingrowth ◽  
Intervertebral Discs ◽  
Disc Replacement ◽  
Segmental Mobility ◽  
Content Type ◽  
Spinal Stabilization ◽  
Titanium Screws ◽  
Flexion Extension ◽  
Fine Print

Object. This 2-year experimental study was conducted to investigate the efficacy of a bioactive three-dimensional (3D) fabric disc for lumbar intervertebral disc replacement. The authors used a bioresorbable spinal fixation rod consisting of a forged composite of particulate unsintered hydroxyapatite/poly-l-lactide acid (HA/PLLA) for stability augmentation. The biomechanical and histological alterations as well as possible device-related loosening were examined at 2 years postoperatively. Methods. Two lumbar intervertebral discs (L2–3 and L4–5) were replaced with the 3D fabric discs, which were augmented by two titanium screws and a spanning bioresorbable rod (HA/PLLA). The segmental biomechanics and interface bone ingrowth were investigated at 6, 15, and 24 months postoperatively, and results were compared with the other two surgical groups (3D fabric disc alone; 3D fabric disc with additional anterior instrumentation stabilization). The 3D fabric disc and HA/PLLA—spinal segments demonstrated segmental mobility at 15 and 24 months; however, the range of motion (ROM) in flexion—extension decreased to 49 and 40%, respectively, despite statistically equivalent preserved torsional ROM. Histologically there was excellent osseous fusion at the 3D fabric disc surface—vertebral body interface. At 2 years posttreatment, no adverse tissue reaction nor aseptic loosening of the device was observed. Conclusions. Intervertebral disc replacement with the 3D fabric disc was viable and when used in conjunction with the bioresorbable HA/PLLA spinal augmentation. Further refinements of device design to create a stand-alone type are necessary to obviate the need for additional spinal stabilization.

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