DNA origami/gold nanorod hybrid nanostructures for the circumvention of drug resistance

Nanoscale ◽  
2017 ◽  
Vol 9 (23) ◽  
pp. 7750-7754 ◽  
Author(s):  
Linlin Song ◽  
Qiao Jiang ◽  
Jianbing Liu ◽  
Na Li ◽  
Qing Liu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dna Origami ◽  
Hybrid Nanostructures ◽  
Gold Nanorod

Experimental Evidence of Plasmophores: Plasmon-Directed Polarized Emission from Gold Nanorod–Fluorophore Hybrid Nanostructures

Nano Letters ◽  
2011 ◽  
Vol 11 (6) ◽  
pp. 2296-2303 ◽  
Author(s):  
Tian Ming ◽  
Lei Zhao ◽  
Huanjun Chen ◽  
Kat Choi Woo ◽  
Jianfang Wang ◽  
...  
Keyword(s):  
Experimental Evidence ◽  
Hybrid Nanostructures ◽  
Gold Nanorod ◽  
Polarized Emission

scholarly journals Plasmon-Emitter Hybrid Nanostructures of Gold Nanorod-Quantum Dots with Regulated Energy Transfer as a Universal Nano-Sensor for One-step Biomarker Detection

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 444
Author(s):  
Xuemeng Li ◽  
Yingshuting Wang ◽  
Quanying Fu ◽  
Yangyang Wang ◽  
Dongxu Ma ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Energy Transfer ◽  
Troponin I ◽  
Limit Of Detection ◽  
Refractive Index Change ◽  
Resonance Energy ◽  
High Sensitivity ◽  
Hybrid Nanostructures ◽  
Gold Nanorod ◽  
Hybrid Nanostructure

Recently, biosensing based on weak coupling in plasmon-emitter hybrid nanostructures exhibits the merits of simplicity and high sensitivity, and attracts increasing attention as an emerging nano-sensor. In this study, we propose an innovative plasmon-regulated fluorescence resonance energy transfer (plasmon-regulated FRET) sensing strategy based on a plasmon-emitter hybrid nanostructure of gold nanorod-quantum dots (Au NR-QDs) by partially modifying QDs onto the surfaces of Au NRs. The Au NR-QDs showed good sensitivity and reversibility against refractive index change. We successfully employed the Au NR-QDs to fabricate nano-sensors for detecting a cancer biomarker of alpha fetoprotein with a limit of detection of 0.30 ng/mL, which displays that the sensitivity of the Au NR-QDs nano-sensor was effectively improved compared with the Au NRs based plasmonic sensing. Additionally, to demonstrate the universality of the plasmon-regulated FRET sensing strategy, another plasmon-emitter hybrid nano-sensor of Au nano-prism-quantum dots (Au NP-QDs) were constructed and applied for detecting a myocardial infarction biomarker of cardiac troponin I. It was first reported that the change of absorption spectra of plasmonic structure in a plasmon-emitter hybrid nanostructure was employed for analytes detection. The plasmon-regulated FRET sensing strategy described herein has potential utility to develop general sensing platforms for chemical and biological analysis.

Microscopic and macroscopic manipulation of gold nanorod and its hybrid nanostructures [Invited]

2013 ◽  
Vol 1 (1) ◽  
pp. 28 ◽  
Author(s):  
Jiafang Li ◽  
Honglian Guo ◽  
Zhi-Yuan Li
Keyword(s):  
Hybrid Nanostructures ◽  
Gold Nanorod

A NEW CORE–SHELL HYBRID NANOSTRUCTURES OF GOLD NANOROD FOR ENHANCING FLUORESCENCE AND APPLICATION IN DUAL-COLOR IMAGING

NANO ◽  
2014 ◽  
Vol 09 (03) ◽  
pp. 1450035
Author(s):  
LU ZHANG ◽  
YAN-JUAN TANG ◽  
YAN-JIE GUO ◽  
JIAN-JUN LUO ◽  
GUI-MIN SUN ◽  
...  
Keyword(s):  
Composite Structures ◽  
Laser Scanning ◽  
Fluorescent Dyes ◽  
Active Surface ◽  
Hybrid Nanostructures ◽  
Gold Nanorod ◽  
Core Shell ◽  
The Novel ◽  
Hybrid Nanostructure ◽  
Dual Color

A novel core–shell hybrid nanostructure was constructed by employing gold nanorod ( AuNR ) combined with rhodamine B (RB) as a core and silica as a shell. The poly(sodium 4-styrenesulfonate) (PSS), a negatively charged polyelectrolyte, played the role of linker to electrostatically trap RB on AuNRs . Due to the fluorescence spectral overlap between RB and AuNRs at 560 nm, the red fluorescence and enhanced green fluorescence of the hybrid nanostructures were observed obviously, which is capable for dual-color labeling. To reduce toxic side effects of AuNRs , silica was coated on AuNRs as a shell to fabricate the novel core–shell hybrid nanostructure function as a dual-color labeling for cancer-cell imaging. The fabricated composite structures were characterized by transmission electron microscopy (TEM), absorption spectrum, fluorescence spectrum, zeta potential measurements and laser scanning confocal microscope (LSCM). The experiment results confirmed that the obtained hybrid nanostructures provided excellent photostability, biocompatibility and active surface for further biological functionalization. The novel composite structures may have great potential application in cell multicolor labeling and imaging instead of traditional fluorescent dyes.

Hierarchical Assembly of DNA Origami Nanostructures Using Coiled-coil Peptides

2019 ◽  
Author(s):  
Alex Buchberger ◽  
Chad Simmons ◽  
Nour Fahmi ◽  
Ronit Freeman ◽  
Nicholas Stephanopoulos
Keyword(s):  
Self Assembly ◽  
Coiled Coil ◽  
Dna Origami ◽  
Hybrid Nanostructures ◽  
Hierarchical Assembly ◽  
Alternating Copolymer ◽  
Self Assembling ◽  
Potential Applications ◽  
Multiple Routes ◽  
Stepwise Assembly

DNA and peptides are two of the most commonly used biomolecules for building self-assembling materials, but few examples exist of hybrid nanostructures that contain both components. Here we report the modification of two peptides that comprise a coiled-coil heterodimer pair with orthogonal DNA handles in order to link DNA origami nanostructures bearing complementary strands into micrometer long one-dimensional arrays. We probed the effect of number of coils on self-assembly and demonstrated the formation of self-assembled structures through multiple routes, to form dimers and trimers, an alternating copolymer of two different origami bundles, and stepwise assembly of purified structures with coiled-coil conjugates. Our results demonstrate the successful merging of two distinct self-assembly modes to create hybrid bionanomaterials expected to have a range of potential applications in the future.

Strong Chiroptical Activities in Gold Nanorod Dimers Assembled Using DNA Origami Templates

ACS Photonics ◽  
2015 ◽  
Vol 2 (3) ◽  
pp. 392-397 ◽  
Author(s):  
Zhong Chen ◽  
Xiang Lan ◽  
Yu-Che Chiu ◽  
Xuxing Lu ◽  
Weihai Ni ◽  
...  
Keyword(s):  
Dna Origami ◽  
Gold Nanorod

scholarly journals Reconfigurable Three-Dimensional Gold Nanorod Plasmonic Nanostructures Organized on DNA Origami Tripod

ACS Nano ◽  
2017 ◽  
Vol 11 (2) ◽  
pp. 1172-1179 ◽  
Author(s):  
Pengfei Zhan ◽  
Palash K. Dutta ◽  
Pengfei Wang ◽  
Gang Song ◽  
Mingjie Dai ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Dna Origami ◽  
Gold Nanorod ◽  
Plasmonic Nanostructures
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