scholarly journals Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry

2017 ◽  
Vol 41 (19) ◽  
pp. 10835-10840 ◽  
Author(s):  
Raluca M. Fratila ◽  
Marcos Navascuez ◽  
Javier Idiago-López ◽  
Maite Eceiza ◽  
José I. Miranda ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Click Chemistry ◽  
New Family ◽  
Covalent Immobilisation

We report a new family of clickable cyclooctynyl magnetic nanoparticles suitable for bioorthogonal click chemistry applications.

scholarly journals Production and covalent immobilisation of the recombinant bacterial carbonic anhydrase (SspCA) onto magnetic nanoparticles

2017 ◽  
Vol 32 (1) ◽  
pp. 759-766 ◽  
Author(s):  
Rosa Perfetto ◽  
Sonia Del Prete ◽  
Daniela Vullo ◽  
Giovanni Sansone ◽  
Carmela M.A. Barone ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Carbonic Anhydrase ◽  
Covalent Immobilisation

Chitosan enhances gene delivery of oligonucleotide complexes with magnetic nanoparticles–cell-penetrating peptide

2018 ◽  
Vol 33 (3) ◽  
pp. 392-401 ◽  
Author(s):  
Moataz Dowaidar ◽  
Hani Nasser Abdelhamid ◽  
Mattias Hällbrink ◽  
Ülo Langel ◽  
Xiaodong Zou
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Small Interfering Rna ◽  
Colloidal Stability ◽  
High Efficiency ◽  
Cell Penetrating Peptides ◽  
New Family ◽  
Cell Penetrating ◽  
Low Efficiency ◽  
Interfering Rna

Gene-based therapies, including the delivery of oligonucleotides, offer promising methods for the treatment of cancer cells. However, they have various limitations including low efficiency. Herein, cell-penetrating peptides (CPPs)-conjugated chitosan-modified iron oxide magnetic nanoparticles (CPPs-CTS@MNPs) with high biocompatibility as well as high efficiency were tested for the delivery of oligonucleotides such as plasmid pGL3, splice correction oligonucleotides, and small-interfering RNA. A biocompatible nanocomposite, in which CTS@MNPs was incorporated in non-covalent complex with CPPs-oligonucleotide, is developed. Modifying the surface of magnetic nanoparticles with cationic chitosan-modified iron oxide improved the performance of magnetic nanoparticles-CPPs for oligonucleotide delivery. CPPs-CTS@MNPs complexes enhance oligonucleotide transfection compared to CPPs@MNPs or CPPs. The hydrophilic character of CTS@MNPs improves complexation with plasmid pGL3, splice correction oligonucleotides, and small-interfering RNA payload, which consequently resulted in not only strengthening the colloidal stability of the constructed complex but also improving their biocompatibility. Transfection using PF14-splice correction oligonucleotides-CTS@MNPs showed sixfold increase of the transfection compared to splice correction oligonucleotides-PF14 that showed higher transfection than the commercially available lipid-based vector Lipofectamine™ 2000. Nanoscaled CPPs-CTS@MNPs comprise a new family of biomaterials that can circumvent some of the limitations of CPPs or magnetic nanoparticles.

scholarly journals Bottom-up design of hydrogels through click-chemistry modification of magnetic nanoparticles

2019 ◽  
Vol 10 (6) ◽  
pp. 386-390
Author(s):  
Ilaria Meazzini ◽  
Massimo Bonini ◽  
Francesca Ridi ◽  
Piero Baglioni
Keyword(s):  
Magnetic Nanoparticles ◽  
Click Chemistry ◽  
Bottom Up

Broad-Range Magnetic Relaxation Switching Bioassays Using Click Chemistry-Mediated Assembly of Polystyrene Beads and Magnetic Nanoparticles

ACS Sensors ◽  
2019 ◽  
Vol 4 (7) ◽  
pp. 1942-1949 ◽  
Author(s):  
Yunlei Xianyu ◽  
Yongzhen Dong ◽  
Zhilong Wang ◽  
Zhenlin Xu ◽  
Riming Huang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Click Chemistry ◽  
Magnetic Relaxation ◽  
Polystyrene Beads

Organosilanes and their Magnetic Nanoparticles as Naked Eye Red Emissive Sensors for Ag+ ions and Potent Anti-oxidants

2021 ◽  
Author(s):  
Gurjaspreet Singh ◽  
Mehta Diksha ◽  
Akshpreet Singh ◽  
Pinky Satija ◽  
Pawan Dahiya ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Click Chemistry ◽  
Present Article ◽  
Structural Characterization ◽  
Naked Eye ◽  
Highly Efficient

The present article reports the synthesis and structural characterization of triazole appended isatin linked silane-based sensor using highly efficient click chemistry approach. The yellow-coloured solution of highly selective chemosensor turned...

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