A new family of biocompatible and stable magnetic nanoparticles: silica cross-linked pluronic F127 micelles loaded with iron oxides

2009 ◽  
Vol 33 (1) ◽  
pp. 88-92 ◽  
Author(s):  
Zhaoyang Liu ◽  
Jun Ding ◽  
Junmin Xue
Keyword(s):  
Magnetic Nanoparticles ◽  
Iron Oxides ◽  
Pluronic F127 ◽  
New Family

scholarly journals Impact of Gadolinium on the Structure and Magnetic Properties of Nanocrystalline Powders of Iron Oxides Produced by the Extraction-Pyrolytic Method

Materials ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 4147
Author(s):  
Vera Serga ◽  
Regina Burve ◽  
Mikhail Maiorov ◽  
Aija Krumina ◽  
Ramūnas Skaudžius ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Thermal Treatment ◽  
Iron Oxides ◽  
Caproic Acid ◽  
Transformation Process ◽  
Nanocrystalline Powders ◽  
Preparation Conditions ◽  
Oxide Phases

Interest in magnetic nanoparticles is primarily due to their practical use. In this work, for the production of nanocrystalline powders of pure and gadolinium doped iron oxides, the extraction-pyrolytic method (EPM) was used. As a precursor, either iron-containing extract (iron (III) caproate in caproic acid) or its mixture with gadolinium-containing extract (gadolinium (III) valerate in valeric acid) was used. The mixed precursor contained 0.5 mol %, 2.5 mol %, 12.5 mol %, 50 mol %, and 75 mol % gadolinium in relation to the iron content. The formation of iron oxide phases, depending on the preparation conditions, was investigated. According to the results obtained, it was demonstrated that the presence of more than 2.5 mol % gadolinium additive in the mixed precursor inhibits the magnetite-to-hematite transformation process during thermal treatment. Produced samples were characterized by XRD and SEM methods, and the magnetic properties were studied.

Chitosan enhances gene delivery of oligonucleotide complexes with magnetic nanoparticles–cell-penetrating peptide

2018 ◽  
Vol 33 (3) ◽  
pp. 392-401 ◽  
Author(s):  
Moataz Dowaidar ◽  
Hani Nasser Abdelhamid ◽  
Mattias Hällbrink ◽  
Ülo Langel ◽  
Xiaodong Zou
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Small Interfering Rna ◽  
Colloidal Stability ◽  
High Efficiency ◽  
Cell Penetrating Peptides ◽  
New Family ◽  
Cell Penetrating ◽  
Low Efficiency ◽  
Interfering Rna

Gene-based therapies, including the delivery of oligonucleotides, offer promising methods for the treatment of cancer cells. However, they have various limitations including low efficiency. Herein, cell-penetrating peptides (CPPs)-conjugated chitosan-modified iron oxide magnetic nanoparticles (CPPs-CTS@MNPs) with high biocompatibility as well as high efficiency were tested for the delivery of oligonucleotides such as plasmid pGL3, splice correction oligonucleotides, and small-interfering RNA. A biocompatible nanocomposite, in which CTS@MNPs was incorporated in non-covalent complex with CPPs-oligonucleotide, is developed. Modifying the surface of magnetic nanoparticles with cationic chitosan-modified iron oxide improved the performance of magnetic nanoparticles-CPPs for oligonucleotide delivery. CPPs-CTS@MNPs complexes enhance oligonucleotide transfection compared to CPPs@MNPs or CPPs. The hydrophilic character of CTS@MNPs improves complexation with plasmid pGL3, splice correction oligonucleotides, and small-interfering RNA payload, which consequently resulted in not only strengthening the colloidal stability of the constructed complex but also improving their biocompatibility. Transfection using PF14-splice correction oligonucleotides-CTS@MNPs showed sixfold increase of the transfection compared to splice correction oligonucleotides-PF14 that showed higher transfection than the commercially available lipid-based vector Lipofectamine™ 2000. Nanoscaled CPPs-CTS@MNPs comprise a new family of biomaterials that can circumvent some of the limitations of CPPs or magnetic nanoparticles.

Mechanochemical Formulation of Coating Iron Oxides Magnetic Nanoparticles with Humics

2012 ◽  
Vol 317-318 (1) ◽  
pp. 169-174 ◽  
Author(s):  
Anna Yurishcheva ◽  
Gulzhian I. Dzhardimalieva ◽  
Svetlana Pomogailo ◽  
Anatoly D. Pomogailo ◽  
Sharipa Jorobekova ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Iron Oxides

Aqueous chemical synthesis of iron oxides magnetic nanoparticles of different morphology and mesostructure

2021 ◽  
Author(s):  
O.A. Shilova ◽  
A.M. Nikolaev ◽  
A.S. Kovalenko ◽  
A.A. Sinel'nikov ◽  
KhE. Yorov ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Chemical Synthesis ◽  
Iron Oxides

Structural and morphological investigation of magnetic nanoparticles based on iron oxides for biomedical applications

2008 ◽  
Vol 28 (4) ◽  
pp. 489-494 ◽  
Author(s):  
Paula S. Haddad ◽  
Tatiana M. Martins ◽  
Lília D'Souza-Li ◽  
Li M. Li ◽  
Konradin Metze ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Iron Oxides ◽  
Biomedical Applications ◽  
Morphological Investigation

scholarly journals Magnetic Nanoparticles for Biomedical Purposes: Modern Trends and Prospects

2020 ◽  
Vol 6 (3) ◽  
pp. 30 ◽  
Author(s):  
Tatyana I. Shabatina ◽  
Olga I. Vernaya ◽  
Vladimir P. Shabatin ◽  
Mikhail Ya. Melnikov
Keyword(s):  
Magnetic Nanoparticles ◽  
Iron Oxides ◽  
Magnetic Nanomaterials ◽  
In Vivo Studies ◽  
Synthesis Methods ◽  
Production Methods ◽  
High Fraction ◽  
Magnetic Diagnostics

The presented paper is a review article discussing existing synthesis methods and different applications of nanosized magnetic nanoparticles. It was shown that, in addition to the spectrum of properties typical for nanomaterials (primarily a large specific surface area and a high fraction of surface atoms), magnetic nanoparticles also possess superparamagnetic properties that contribute to their formation of an important class of biomedical functional nanomaterials. This primarily concerns iron oxides magnetite and maghemite, for which in vitro and in vivo studies have shown low toxicity and high biocompatibility in comparison with other magnetic nanomaterials. Due to their exceptional chemical, biological, and physical properties, they are widely used in various areas, such as magnetic hyperthermia, targeted drug delivery, tissue engineering, magnetic separation of biological objects (cells, bacteria, viruses, DNA, and proteins), and magnetic diagnostics (they are used as agents for MRS and immunoassay). In addition to discussing the main problems and prospects of using nanoparticles of magnetic iron oxides for advanced biomedical applications, information is also reflected on their structure, production methods, and properties.

scholarly journals Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry

2017 ◽  
Vol 41 (19) ◽  
pp. 10835-10840 ◽  
Author(s):  
Raluca M. Fratila ◽  
Marcos Navascuez ◽  
Javier Idiago-López ◽  
Maite Eceiza ◽  
José I. Miranda ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Click Chemistry ◽  
New Family ◽  
Covalent Immobilisation

We report a new family of clickable cyclooctynyl magnetic nanoparticles suitable for bioorthogonal click chemistry applications.

INSILICO MODELING AND SIMULATION OF MAGNETIC NANOPARTICLES FOR THE BIOLOGICAL CELL ISOLATION TECHNIQUE

2011 ◽  
Vol 10 (01n02) ◽  
pp. 323-327
Author(s):  
K. VARUN GOPAL ◽  
P. K. KRISHNAN NAMBOORI ◽  
P. PREMKUMAR ◽  
DEEPA GOPAKUMAR ◽  
B. SABARISH NARAYANAN
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
External Magnetic Field ◽  
Iron Oxides ◽  
Human Body ◽  
Controlled Drug Release ◽  
Cell Isolation ◽  
Isolation Technique ◽  
Simulation Techniques ◽  
Cellular Compartments

Magnetic nanoparticles (MNPs) can be used in a wide variety of biomedical applications like contrast agents for magnetic resonance imaging, magnetic labeling, controlled drug release, hyperthermia, and in cell isolation. Most of these applications need distinct and controllable interactions between the MNPs and living cells and can be made possible by a proper functionalization technique. This paper describes a computational approach for the identification of magnetic nanoparticles for the development, design, and demonstration of a novel, incorporated system for selective and rapid removal of biological, chemical, and radioactive biohazards from human body. The attraction between an external magnetic field and the MNPs facilitate separation of a wide variety of biological materials. This principle can be used for the isolation and aggregation of wandering cancer cells from the blood or the bone marrow to make a proper and early diagnosis of leukemia. Similarly, toxins, kidney stones, and other unwanted particles in the human body can be easily diagnosed and removed by the same technique. Nanoparticle-sized iron oxides have been studied in this work by computational modeling and molecular dynamic (MD) simulation techniques. Structural, thermodynamic, and magnetic properties have been formulated. In this work, nanoparticles of size varying from 0.5 to 2.5 nm have been analyzed. Cell isolation ability of the nanoparticles has been compared based on the computational results. MNPs are biologically activated and permitted to bind with the targeted cells through various pathways, thereby allowing certain cellular compartments to be specifically addressed. Once the cells are identified, the preferred cellular compartments can be magnetically isolated and removed with the help of an external magnetic field. Out of the iron oxides analyzed in this work, 1.1 nm Fe3O4 is found to be most interacting with leukemia protein. Hence, leukemia cells can be effectively targeted, separated, and removed using Fe3O4 of the suggested dimension.

Isolation of magnetic nanoparticles from pachycondyla marginata ants

1999 ◽  
Vol 202 (19) ◽  
pp. 2687-2692
Author(s):  
D. Acosta-Avalos ◽  
E. Wajnberg ◽  
P.S. Oliveira ◽  
I. Leal ◽  
M. Farina ◽  
...  
Keyword(s):  
Magnetic Material ◽  
Magnetic Nanoparticles ◽  
Size Distribution ◽  
Iron Oxides ◽  
Geomagnetic Field ◽  
Magnetic Particles ◽  
The Body ◽  
Magnetic Orientation ◽  
Diffraction Patterns ◽  
Different Parts

We report on the presence of magnetic iron oxides in the migratory ant Pachycondyla marginata. Magnetic particles were extracted from different parts of the ant (head, thorax and abdomen) using magnetic precipitation methods. Electron spectroscopic images for iron and oxygen were obtained from the extracted particles, and, by using the corresponding electron micrographs, histograms of size distribution were constructed. Selected area diffraction patterns were also obtained from the particles, and analysis of these showed the presence of a mixture of different iron oxides, including the magnetic oxides, magnetite and maghemite. The size distribution of the particles in the abdomen is different from that in the thorax and the head. In accordance with the hypothesis of magnetic orientation based on the presence of magnetic material within the body, two regions of the ant, the head and the abdomen, could be implicated in the detection of the geomagnetic field.

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