Synthesis of 4-aryl-1,2,3-triazolyl appended natural coumarin-related compounds with antiproliferative and radical scavenging activities and intracellular ROS production modification

2017 ◽  
Vol 41 (15) ◽  
pp. 7531-7543 ◽  
Author(s):  
A. Bistrović ◽  
N. Stipaničev ◽  
T. Opačak-Bernardi ◽  
M. Jukić ◽  
S. Martinez ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
K562 Cells ◽  
Ros Production ◽  
Scavenging Activity ◽  
Intracellular Ros ◽  
Natural Coumarin ◽  
Related Compounds

Diverse natural coumarin-based compounds linked to aryl via a 1,2,3-triazole spacer with antiproliferative activity against K562 cells, radical scavenging activity and a decrease of ROS production were provided.

scholarly journals Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1608
Author(s):  
Stephen Lo ◽  
Euphemia Leung ◽  
Bruno Fedrizzi ◽  
David Barker
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Breast Cancer Cell Lines ◽  
Scavenging Activity ◽  
Plant Materials ◽  
Wide Range ◽  
Derivatives Of ◽  
Acyl Derivatives

Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.

scholarly journals Comparison of Antiproliferative and Antioxidant Properties among Nineteen Apple Cultivars

HortScience ◽  
2005 ◽  
Vol 40 (5) ◽  
pp. 1204-1207 ◽  
Author(s):  
Yuko Yoshizawa ◽  
Kenji Sakurai ◽  
Satoru Kawaii ◽  
Masayoshi Asari ◽  
Junichi Soejima ◽  
...  
Keyword(s):  
Antiproliferative Activity ◽  
High Performance ◽  
Radical Scavenging Activity ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Careful Examination ◽  
Anthocyanin Content ◽  
Scavenging Activity ◽  
Total Anthocyanins ◽  
Apple Cultivars

Aqueous ethanol extracts prepared from 19 apple (Malus ×domestica Borkh.) cultivars were studied to explore their antiproliferative activity. Half of them showed strong inhibition on proliferation of human leukemic HL-60 cells, while the others were weak. Total polyphenols, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, and total anthocyanins were measured and the results indicated that the antiproliferative activity was more strongly correlated to the polyphenols and radical scavenging activity than to the anthocyanin content. Several polyphenols in `Jonathan' were identified and quantified by high-performance liquid chromatography (HPLC) analysis. Among those compounds found during HPLC, catechin and epicatechin seemed partially responsible for HL-60 antiproliferation. A careful examination on parentage of the apple cultivars tested revealed that `Jonathan' and its progeny showed high antiproliferation toward HL-60. This is the first observation about the relationship between antiproliferative activity and parentage of apples, and the information would be useful to create new apple cultivars that posses more anticancer potential.

Radical Scavenging Activity of Tea Catechins and Their Related Compounds

1999 ◽  
Vol 63 (9) ◽  
pp. 1621-1623 ◽  
Author(s):  
Fumio NANJO ◽  
Masao MORI ◽  
Keiichi GOTO ◽  
Yukihiko HARA
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
Tea Catechins ◽  
Related Compounds

scholarly journals An Unusual Bisnor-clerodane Diterpenoid from Polyalthia Simiarum

2010 ◽  
Vol 5 (10) ◽  
pp. 1934578X1000501
Author(s):  
Selina Kabir ◽  
Mohammad S. Rahman ◽  
A. M. Sarwaruddin Chowdhury ◽  
Choudhury M. Hasan ◽  
Mohammad A. Rashid
Keyword(s):  
Free Radical ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Stem Bark ◽  
Free Radical Scavenging ◽  
Light Petroleum ◽  
Scavenging Activity ◽  
Nmr Studies ◽  
Clerodane Diterpenoid ◽  
Related Compounds

The stem bark of Polyalthia simiarum has yielded a new bisnor-type clerodane diterpenoid, 2-oxo-14,15-bisnor-3,11 E-kolavadien-13-one (1), and three previously known clerodane derivatives, kolavenic acid (2), 16β-hydroxycleroda-3,13(14) Z-dien-15,16-olide (3), and 16-oxocleroda-3,13(14) E-dien-15-oic acid (4). The structures of these compounds were unambiguously determined by extensive NMR studies as well as by comparison with related compounds. Till now this is the second report of the occurrence of any unusual C-18 clerodane diterpenoid from nature. The crude light petroleum extract and the purified compound 3 demonstrated moderate free radical scavenging activity with IC50 values of 21.5 and 23.5 μg/mL, respectively.

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