High performance photosensitizers with aggregation-induced emission for image-guided photodynamic anticancer therapy

2017 ◽  
Vol 4 (6) ◽  
pp. 1110-1114 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Shidang Xu ◽  
Shenglu Ji ◽  
Fang Hu ◽  
...  

A series of D–A′–π–A type photosensitizers were designed and synthesized to show strong aggregation-induced far red and near infrared emission and very effective 1O2 generation simultaneously, and have been successfully used for image-guided photodynamic anticancer therapy.

2019 ◽  
Vol 10 (9) ◽  
pp. 2785-2790 ◽  
Author(s):  
Rongchen Wang ◽  
Kaikai Dong ◽  
Ge Xu ◽  
Ben Shi ◽  
Tianli Zhu ◽  
...  

A theranostic platform enables the selective visualization of H2S-rich cancers and imaging-directed on-demand photodynamic therapy of the detected cancers while leaving normal tissues untouched.


2019 ◽  
Vol 43 (8) ◽  
pp. 3317-3322 ◽  
Author(s):  
Chenyang Han ◽  
Shengjie Jiang ◽  
Jiabin Qiu ◽  
Hongyu Guo ◽  
Fafu Yang

The strong aggregation induced emission–fluorescence resonance energy transfer (AIE–FRET) effect was observed for diphenylacrylonitrile units and porphyrin units.


2016 ◽  
Vol 09 (03) ◽  
pp. 1650038 ◽  
Author(s):  
Ping Liu ◽  
Wei Miu

In this paper, we demonstrate multifunctional upconversion nanoparticles with intense near-infrared emission and unique magnetic properties for dual-modal upconversion luminescent bioimaging and T2-weighted magnetic resonance imaging. High-quality BaYbF5:Tm3+ nanoparticles are synthesized via a hydrophobic method and then converted to be hydrophilic via a hydrochloric acid treatment. The as-synthesized nanoparticles are cubic phase and about 6 nm in diameter with narrow size distribution. The intense near-infrared emission makes these nanoparticles can be acted as bio-probes in upconversion luminescent bioimaging with deep tissue penetration. Besides, these nanoparticles can also be used as T2-weighted contrast agents in magnetic resonance imaging due to the high value of relaxation rate (r2 = 4.05) in 0.55 T. This finding may have further bio-applications in the future due to the high performance of these BaYbF5:Tm3+ nanoparticles in dual-modal bioimaging.


2014 ◽  
Vol 5 (24) ◽  
pp. 7013-7020 ◽  
Author(s):  
Zilong Wang ◽  
Lulin Yan ◽  
Lei Zhang ◽  
Yujue Chen ◽  
Hui Li ◽  
...  

An aggregation-induced emission (AIE) molecule, TPA-AN-TPM, with near-infrared emission was synthesized by coating a disc-like red emission fluorophore with a propeller-shaped AIE fluorophore.


2020 ◽  
Vol 56 (46) ◽  
pp. 6305-6308 ◽  
Author(s):  
Patteera Funchien ◽  
Pongsakorn Chasing ◽  
Taweesak Sudyoadsuk ◽  
Vinich Promarak

Naphthothiadiazole derivatives with aggregation-induced emission enhancement exhibited a non-doped EL device emitted brilliant near infrared emission peaked at 754 nm with high EQE as high as 1.48%.


2020 ◽  
Vol 224 ◽  
pp. 117313 ◽  
Author(s):  
Shaohua Meng ◽  
Guoying Zhao ◽  
Jingshan Hou ◽  
Yufeng Liu ◽  
Yanyan Guo ◽  
...  

CrystEngComm ◽  
2020 ◽  
Vol 22 (8) ◽  
pp. 1359-1367 ◽  
Author(s):  
Qinqin Shao ◽  
Chao Yang ◽  
Xiaoxu Chen ◽  
Hong Zhang ◽  
Guoying Feng ◽  
...  

High-performance α-NaGdF4@β-NaLuF4:Nd3+ nanocrystals have been constructed based on a core-mediated method. Their near-infrared emission intensity was eventually enhanced by more than 2 times.


2016 ◽  
Vol 4 (45) ◽  
pp. 10588-10609 ◽  
Author(s):  
Qiuli Zhao ◽  
Jing Zhi Sun

Combining the strategies of the reduction of the energy gap and the mechanism of aggregation-induced emission is an effective way to create red and near infrared emission molecules.


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