scholarly journals Cancer nanomedicine: from PDGF targeted drug delivery

MedChemComm ◽  
2017 ◽  
Vol 8 (11) ◽  
pp. 2055-2059 ◽  
Author(s):  
Chandrababu Rejeeth ◽  
Raju Vivek ◽  
Varukattu NipunBabu ◽  
Alok Sharma ◽  
Xianting Ding ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Innovative Approach ◽  
Specific Cell ◽  
Cell Type ◽  
Specific Cell Type ◽  
Cancer Nanomedicine ◽  
Targeted Drug ◽  
Modification Of The Surface

An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles.

scholarly journals Nanoparticle-Induced Complement Activation: Implications for Cancer Nanomedicine

2021 ◽  
Vol 11 ◽  
Author(s):  
Ninh M. La-Beck ◽  
Md. Rakibul Islam ◽  
Maciej M. Markiewski
Keyword(s):  
Drug Delivery ◽  
Complement Activation ◽  
Targeted Drug Delivery ◽  
Adverse Reactions ◽  
Inflammatory Reactions ◽  
Complex Interactions ◽  
Cancer Nanomedicine ◽  
Targeted Drug ◽  
Reduced Toxicity

Nanoparticle-based anticancer medications were first approved for cancer treatment almost 2 decades ago. Patients benefit from these approaches because of the targeted-drug delivery and reduced toxicity, however, like other therapies, adverse reactions often limit their use. These reactions are linked to the interactions of nanoparticles with the immune system, including the activation of complement. This activation can cause well-characterized acute inflammatory reactions mediated by complement effectors. However, the long-term implications of chronic complement activation on the efficacy of drugs carried by nanoparticles remain obscured. The recent discovery of protumor roles of complement raises the possibility that nanoparticle-induced complement activation may actually reduce antitumor efficacy of drugs carried by nanoparticles. We discuss here the initial evidence supporting this notion. Better understanding of the complex interactions between nanoparticles, complement, and the tumor microenvironment appears to be critical for development of nanoparticle-based anticancer therapies that are safer and more efficacious.

scholarly journals Avidity and surface mobility in multivalent ligand-receptor binding

Nanoscale ◽  
2021 ◽  
Author(s):  
Simon Merminod ◽  
John R. Edison ◽  
Huang Fang ◽  
Michael F. Hagan ◽  
W. Benjamin Rogers
Keyword(s):  
Drug Delivery ◽  
Cell Membrane ◽  
Receptor Binding ◽  
Targeted Drug Delivery ◽  
Specific Cell ◽  
Physical Processes ◽  
Selective Binding ◽  
Surface Mobility ◽  
Targeted Drug

Targeted drug delivery relies on two physical processes: the selective binding of a therapeutic particle to receptors on a specific cell membrane, followed by transport of the particle across the...

Nanosponges: An innovative approach for targeted drug delivery system

2021 ◽  
Vol 14 (3) ◽  
pp. 1797-1804
Author(s):  
Shashikant Sudarshan Upadhye ◽  
Srinath Balkundhi ◽  
Vishwajeet Sampatrao Ghorpade ◽  
Shirishkumar Damodar Ambavade ◽  
Sujit Vitthal Abhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Innovative Approach ◽  
Targeted Drug ◽  
Targeted Drug Delivery System
Sign in / Sign up

Export Citation Format

Share Document