scholarly journals Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5′-UTR

2017 ◽  
Vol 13 (8) ◽  
pp. 1448-1457 ◽  
Author(s):  
Damian S. McAninch ◽  
Ashley M. Heinaman ◽  
Cara N. Lang ◽  
Kathryn R. Moss ◽  
Gary J. Bassell ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Motor Neuron ◽  
Fragile X ◽  
Survival Motor Neuron ◽  
Spliceosome Assembly ◽  
Fragile X Mental Retardation ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Mental Retardation Protein

SMNDC1 mRNA adopts a 5′-UTR G quadruplex structure recognized specifically by FMRP, potentially affecting spliceosome assembly in FXS.

scholarly journals Fragile X mental retardation protein interactions with a G quadruplex structure in the 3′-untranslated region of NR2B mRNA

2015 ◽  
Vol 11 (12) ◽  
pp. 3222-3230 ◽  
Author(s):  
Snezana Stefanovic ◽  
Brett A. DeMarco ◽  
Ayana Underwood ◽  
Kathryn R. Williams ◽  
Gary J. Bassell ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Intellectual Disability ◽  
Protein Interactions ◽  
Untranslated Region ◽  
Fragile X ◽  
Common Cause ◽  
Fragile X Mental Retardation ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Mental Retardation Protein

Fragile X syndrome, the most common cause of inherited intellectual disability, is caused by a trinucleotide CGG expansion in the 5′-untranslated region of the FMR1 gene, which leads to the loss of expression of the fragile X mental retardation protein (FMRP).

scholarly journals In Vitroandin CelluloEvidences for Association of the Survival of Motor Neuron Complex with the Fragile X Mental Retardation Protein

2007 ◽  
Vol 283 (9) ◽  
pp. 5598-5610 ◽  
Author(s):  
Nathalie Piazzon ◽  
Florence Rage ◽  
Florence Schlotter ◽  
Hervé Moine ◽  
Christiane Branlant ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Motor Neuron ◽  
Fragile X ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein ◽  
Survival Of Motor Neuron
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