Analysis of the Fragile X mental retardation protein isoforms 1, 2 and 3 interactions with the G-quadruplex forming semaphorin 3F mRNA

2012 ◽  
Vol 8 (2) ◽  
pp. 642-649 ◽  
Author(s):  
Timothy L. Evans ◽  
Anna C. Blice-Baum ◽  
Mihaela-Rita Mihailescu
Keyword(s):  
Mental Retardation ◽  
Fragile X ◽  
Protein Isoforms ◽  
Fragile X Mental Retardation ◽  
Semaphorin 3F ◽  
G Quadruplex ◽  
Mental Retardation Protein

scholarly journals Fragile X mental retardation protein interactions with a G quadruplex structure in the 3′-untranslated region of NR2B mRNA

2015 ◽  
Vol 11 (12) ◽  
pp. 3222-3230 ◽  
Author(s):  
Snezana Stefanovic ◽  
Brett A. DeMarco ◽  
Ayana Underwood ◽  
Kathryn R. Williams ◽  
Gary J. Bassell ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Intellectual Disability ◽  
Protein Interactions ◽  
Untranslated Region ◽  
Fragile X ◽  
Common Cause ◽  
Fragile X Mental Retardation ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Mental Retardation Protein

Fragile X syndrome, the most common cause of inherited intellectual disability, is caused by a trinucleotide CGG expansion in the 5′-untranslated region of the FMR1 gene, which leads to the loss of expression of the fragile X mental retardation protein (FMRP).

scholarly journals Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5′-UTR

2017 ◽  
Vol 13 (8) ◽  
pp. 1448-1457 ◽  
Author(s):  
Damian S. McAninch ◽  
Ashley M. Heinaman ◽  
Cara N. Lang ◽  
Kathryn R. Moss ◽  
Gary J. Bassell ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Motor Neuron ◽  
Fragile X ◽  
Survival Motor Neuron ◽  
Spliceosome Assembly ◽  
Fragile X Mental Retardation ◽  
Quadruplex Structure ◽  
G Quadruplex ◽  
Mental Retardation Protein

SMNDC1 mRNA adopts a 5′-UTR G quadruplex structure recognized specifically by FMRP, potentially affecting spliceosome assembly in FXS.

scholarly journals Expression and Characterization of Human Fragile X Mental Retardation Protein Isoforms and Interacting Proteins in Human Cells

2019 ◽  
Vol 10 ◽  
pp. 117864181882526
Author(s):  
Jiang Zhang ◽  
Guangli Wang ◽  
Wei-Wu He ◽  
Molly Losh ◽  
Elizabeth Berry-Kravis ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Fragile X ◽  
Human Cells ◽  
Protein Isoforms ◽  
Interacting Proteins ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein
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