Magnetic particles assisted capture and release of rare circulating tumor cells using wavy-herringbone structured microfluidic devices

Lab on a Chip ◽  
2017 ◽  
Vol 17 (19) ◽  
pp. 3291-3299 ◽  
Author(s):  
Wentao Shi ◽  
Shunqiang Wang ◽  
Ahmad Maarouf ◽  
Christopher G. Uhl ◽  
Ran He ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Magnetic Particles ◽  
Microfluidic Devices ◽  
Rare Tumor ◽  
Capture And Release

Wavy-herringbone structured microfluidic devices promote capture and collection of rare tumor cells assisted by magnetic particles.

Biomimetic recognition strategy for efficient capture and release of circulating tumor cells

2021 ◽  
Vol 188 (6) ◽  
Author(s):  
Ji Zheng ◽  
Dayong Li ◽  
Jin Jiao ◽  
Chengjie Duan ◽  
Youjing Gong ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Capture And Release

scholarly journals Nanotechnology-Assisted Isolation and Analysis of Circulating Tumor Cells on Microfluidic Devices

Micromachines ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 774 ◽  
Author(s):  
Jie Cheng ◽  
Yang Liu ◽  
Yang Zhao ◽  
Lina Zhang ◽  
Lingqian Zhang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Liquid Biopsy ◽  
Cancer Metastasis ◽  
Human Peripheral Blood ◽  
Microfluidic Devices ◽  
Detection Sensitivity ◽  
Cell Capture ◽  
Primary Tumors ◽  
Downstream Analysis

Circulating tumor cells (CTCs), a type of cancer cell that spreads from primary tumors into human peripheral blood and are considered as a new biomarker of cancer liquid biopsy. It provides the direction for understanding the biology of cancer metastasis and progression. Isolation and analysis of CTCs offer the possibility for early cancer detection and dynamic prognosis monitoring. The extremely low quantity and high heterogeneity of CTCs are the major challenges for the application of CTCs in liquid biopsy. There have been significant research endeavors to develop efficient and reliable approaches to CTC isolation and analysis in the past few decades. With the advancement of microfabrication and nanomaterials, a variety of approaches have now emerged for CTC isolation and analysis on microfluidic platforms combined with nanotechnology. These new approaches show advantages in terms of cell capture efficiency, purity, detection sensitivity and specificity. This review focuses on recent progress in the field of nanotechnology-assisted microfluidics for CTC isolation and detection. Firstly, CTC isolation approaches using nanomaterial-based microfluidic devices are summarized and discussed. The different strategies for CTC release from the devices are specifically outlined. In addition, existing nanotechnology-assisted methods for CTC downstream analysis are summarized. Some perspectives are discussed on the challenges of current methods for CTC studies and promising research directions.

Folic Acid-Functionalized Hybrid Photonic Barcodes for Capture and Release of Circulating Tumor Cells

2018 ◽  
Vol 10 (25) ◽  
pp. 21206-21212 ◽  
Author(s):  
Chengxin Luan ◽  
Huan Wang ◽  
Qi Han ◽  
Xiaoyan Ma ◽  
Dagan Zhang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Capture And Release

scholarly journals Photoresponsive immunomagnetic nanocarrier for capture and release of rare circulating tumor cells

2015 ◽  
Vol 6 (11) ◽  
pp. 6432-6438 ◽  
Author(s):  
Song-Wei Lv ◽  
Jing Wang ◽  
Min Xie ◽  
Ning-Ning Lu ◽  
Zhen Li ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Release System ◽  
System P ◽  
Capture And Release

7-Aminocoumarin compound was synthesized and used as phototrigger to cage EpCAM-antibody to construct a photocontrolled CTCs capture and release system.

Interactions Between Circulating Tumor Cells and Aptamer-Functionalized Microposts in a Flow

2017 ◽  
Author(s):  
Kangfu Chen ◽  
Teodor Georgiev ◽  
Z. Hugh Fan
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Microfluidic Device ◽  
Blood Cells ◽  
Volume Ratio ◽  
Microfluidic Devices ◽  
Cancer Prognosis ◽  
Device Performance ◽  
Simulation Methodology ◽  
Geometry Design

Circulating Tumor Cells (CTCs) have been considered as important biomarkers for cancer prognosis and treatment. However, there are only tens of CTCs in one billion of healthy blood cells. This CTC rarity challenge has been addressed by microfluidics technology that sheds light on efficient CTC detection and isolation. Using antibodies or aptamers to capture CTCs is one of the strategies for CTC isolation. A lot of work has been carried out to improve CTC capture efficiency and purity (i.e., specificity). The main consideration to optimize microfluidic device performance includes increasing surface-area-to-volume ratio and reducing shear stress, both of which are closely related to the interaction between CTCs and the microfluidic device. Here we report a detailed study on the interactions between CTCs and aptamer-functionalized microposts in a microfluidic device. We have evaluated the distribution of captured CTCs around a micropost. In addition, simulation was conducted to model CTC capture patterns around microposts. We found the simulated CTC capture pattern largely agree with the experimental results. The simulation methodology could be applicable for other affinity-based CTC isolation devices and approaches. The goal of the study is to improve the microfluidic device performance and provide a rapid and economical way to optimize the geometry design of the microfluidic devices for CTC isolation.

Bioinspired Engineering of a Multivalent Aptamer‐Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells

2019 ◽  
Vol 58 (8) ◽  
pp. 2236-2240 ◽  
Author(s):  
Yanling Song ◽  
Yuanzhi Shi ◽  
Mengjiao Huang ◽  
Wei Wang ◽  
Yang Wang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Capture And Release
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