A dual-templating strategy for the scale-up synthesis of dendritic mesoporous silica nanospheres

2017 ◽  
Vol 19 (23) ◽  
pp. 5575-5581 ◽  
Author(s):  
Peng-Cheng Liu ◽  
Ye-Jun Yu ◽  
Bo Peng ◽  
Shi-Yu Ma ◽  
Tian-Yu Ning ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anionic Surfactant ◽  
Cetyltrimethylammonium Bromide ◽  
Mesoporous Silica Nanoparticles ◽  
Scale Up ◽  
Silica Nanospheres ◽  
Pore Structures ◽  
Mesoporous Silica Nanospheres

Mesoporous silica nanoparticles with varied morphologies and pore structures were synthesized on the kilogram scale using cetyltrimethylammonium bromide and an anionic surfactant as co-templates.

A non-surfactant self-templating strategy for mesoporous silica nanospheres: beyond the Stöber method

Nanoscale ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 3657-3662 ◽  
Author(s):  
Zhe Chen ◽  
Bo Peng ◽  
Jia-Qiong Xu ◽  
Xue-Chen Xiang ◽  
Dong-Fang Ren ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Size Distribution ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanospheres ◽  
Stöber Method ◽  
Directed Synthesis ◽  
The Stöber Method ◽  
Surfactant Templates ◽  
Mesoporous Silica Nanospheres

The “pre-Ouzo” structure directed synthesis of mesoporous silica nanoparticles (MSNs) in the absence of surfactant templates probably also explains the origin of highly monodisperse size distribution of classical Stöber silica NPs.

scholarly journals Mixed anionic surfactant-templated mesoporous silica nanoparticles for fluorescence detection of Fe3+

2016 ◽  
Vol 45 (2) ◽  
pp. 508-514 ◽  
Author(s):  
Fangyuan Gai ◽  
Tianlei Zhou ◽  
Guang Chu ◽  
Ye Li ◽  
Yunling Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fluorescence Detection ◽  
Anionic Surfactant ◽  
Anionic Surfactants ◽  
Mesoporous Silica Nanoparticles ◽  
Fluorescent Detection ◽  
Amino Group ◽  
Design And Synthesis ◽  
Soft Templates

This work demonstrates the design and synthesis of large pore mesoporous silica nanoparticles by using mixed anionic surfactants as soft templates to introduce amino group for Fe3+ fluorescent detection.

Surfactant-assisted controlled release of hydrophobic drugs using anionic surfactant templated mesoporous silica nanoparticles

Biomaterials ◽  
2011 ◽  
Vol 32 (26) ◽  
pp. 6234-6244 ◽  
Author(s):  
Chih-Hsiang Tsai ◽  
Juan L. Vivero-Escoto ◽  
Igor I. Slowing ◽  
I-Ju Fang ◽  
Brian G. Trewyn ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anionic Surfactant ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrophobic Drugs ◽  
Surfactant Assisted

scholarly journals The Design of Anionic Surfactant-Based Amino-Functionalized Mesoporous Silica Nanoparticles and their Application in Transdermal Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1035
Author(s):  
Aliyah Almomen ◽  
Ahmed M. El-Toni ◽  
Mohammed Badran ◽  
Adel Alhowyan ◽  
Mohd Abul Kalam ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anionic Surfactant ◽  
Mesoporous Silica Nanoparticles ◽  
Synergetic Effect ◽  
Melanoma Cells ◽  
Skin Permeability ◽  
Loading Capacity ◽  
Structure Directing Agent ◽  
Functionalized Mesoporous Silica

Melanoma remains the most lethal form of skin cancer and most challenging to treat despite advances in the oncology field. Our work describes the utilization of nanotechnology to target melanoma locally in an attempt to provide an advanced and efficient quality of therapy. Amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were developed in situ through the utilization of anionic surfactant and different volumes of 3-aminopropyltriethoxysilane (APTES) as a co-structure directing agent (CSDA). Prepared particles were characterized for their morphology, particles size, 5-flurouracol (5-FU) and dexamethasone (DEX) loading capacity and release, skin penetration, and cytotoxicity in vitro in HT-144 melanoma cells. Results of transmission electron microscopy (TEM) and nitrogen adsorption–desorption isotherm showed that using different volumes of APTES during the functionalization process had an impact on the internal and external morphology of the particles, as well as particle size. However, changing the volume of APTES did not affect the diameter of formed mesochannels, which was about 4 nm. MSN-NH2 showed a relatively high loading capacity of 5-FU (12.6 ± 5.5) and DEX (44.72 ± 4.21) when using drug: MSN-NH2 ratios of 5:1 for both drugs. The release profile showed that around 83% of 5-FU and 21% of DEX were released over 48 h in pH 7.4. The skin permeability study revealed that enhancement ratio of 5-Fu and DEX using MSN-NH2 were 4.67 and 5.68, respectively, relative to their free drugs counterparts. In addition, the accumulation of drugs in skin layers where melanoma cells usually reside were enhanced approximately 10 times with 5-FU and 5 times with DEX when delivering drugs using MSN-NH2 compared to control. MSN-NH2 alone was nontoxic to melanoma cells when incubated for 48 h in the range of 0 to 468 µg/mL. The combination of 5-FU MSN-NH2 and DEX MSN-NH2 showed significant increase in toxicity compared to their free dug counterparts and exhibited a synergetic effect as well as the ability to circumvent DEX induced 5-FU resistance in melanoma cells.

Formation of mesoporous silica nanoparticles with tunable pore structure as promising nanoreactor and drug delivery vehicle

RSC Advances ◽  
2016 ◽  
Vol 6 (16) ◽  
pp. 13303-13311 ◽  
Author(s):  
Lu Wu ◽  
Zheng Jiao ◽  
Minghong Wu ◽  
Tingting Song ◽  
Haijiao Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Pore Structure ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Pore Structures

Mesoporous silica nanoparticles with tunable pore structures have been successfully fabricated by simply tuning the ethanol amounts in the precursor.

scholarly journals Long Chain Imidazolium Ionic Liquids as Templates in the Formation of Mesoporous Silica Nanospheres

2020 ◽  
Vol 301 ◽  
pp. 209-216
Author(s):  
Eleen Dayana Mohamed Isa ◽  
Haslina Ahmad ◽  
Mohd Basyaruddin Abdul Rahman
Keyword(s):  
Ionic Liquids ◽  
Mesoporous Silica ◽  
Chain Length ◽  
Alkyl Chain ◽  
Mesoporous Silica Nanoparticles ◽  
High Specific Surface Area ◽  
Alkyl Chain Length ◽  
Silica Nanospheres ◽  
Long Chain ◽  
Mesoporous Silica Nanospheres

Mesoporous silica material was first discovered by Mobil research group in 1990s. Its nanoscale form is favorable due to their properties such as high specific surface area, tunable sizes and easy surface functionalization. Mesoporous silica nanoparticles (MSNs) is commonly synthesize through condensation of silica source in the presence of templates. Two most commonly used templates are cetyltrimethylammonium bromide (CTAB) and polymer PF-127. However, in these recent years, new templates were discovered and one of it is ionic liquids (ILs). ILs are salt that has melting point below 100 °C and its core structure is similar to CTAB which consist of large organic cations and inorganic or organic anions. Therefore, it has the potential to serve as alternative template in formation of MSNs. This work reported usage of two long chain imidazolium ILs as template in the synthesis of monodispersed mesoporous silica nanospheres (MNSs). The effect of imidazolium ILs alkyl chain length on properties of MNSs were investigated. It was found that particle size of MNSs decreases with alkyl chain length of imidazolium ILs. The porosity of the MNSs were further analyzed through nitrogen sorption analysis where the surface areas were 570.61 and 598.71 m2 g-1 and pore volume up to 1.4 cm3 g-1.

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