scholarly journals Mixed anionic surfactant-templated mesoporous silica nanoparticles for fluorescence detection of Fe3+

2016 ◽  
Vol 45 (2) ◽  
pp. 508-514 ◽  
Author(s):  
Fangyuan Gai ◽  
Tianlei Zhou ◽  
Guang Chu ◽  
Ye Li ◽  
Yunling Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fluorescence Detection ◽  
Anionic Surfactant ◽  
Anionic Surfactants ◽  
Mesoporous Silica Nanoparticles ◽  
Fluorescent Detection ◽  
Amino Group ◽  
Design And Synthesis ◽  
Soft Templates

This work demonstrates the design and synthesis of large pore mesoporous silica nanoparticles by using mixed anionic surfactants as soft templates to introduce amino group for Fe3+ fluorescent detection.

Tannin as a gatekeeper of pH-responsive mesoporous silica nanoparticles for drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85436-85441 ◽  
Author(s):  
Chunlin Hu ◽  
Lingxue Yu ◽  
Zhen Zheng ◽  
Jing Wang ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Amino Group ◽  
Ph Responsive ◽  
Amidation Reaction

Tannin grafted on mesoporous silica nanoparticles (tannin-MSNs) was synthesized by the amidation reaction of carboxyl benzyl borate with amino group modified MSN.

Surfactant-assisted controlled release of hydrophobic drugs using anionic surfactant templated mesoporous silica nanoparticles

Biomaterials ◽  
2011 ◽  
Vol 32 (26) ◽  
pp. 6234-6244 ◽  
Author(s):  
Chih-Hsiang Tsai ◽  
Juan L. Vivero-Escoto ◽  
Igor I. Slowing ◽  
I-Ju Fang ◽  
Brian G. Trewyn ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anionic Surfactant ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrophobic Drugs ◽  
Surfactant Assisted

A dual-templating strategy for the scale-up synthesis of dendritic mesoporous silica nanospheres

2017 ◽  
Vol 19 (23) ◽  
pp. 5575-5581 ◽  
Author(s):  
Peng-Cheng Liu ◽  
Ye-Jun Yu ◽  
Bo Peng ◽  
Shi-Yu Ma ◽  
Tian-Yu Ning ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anionic Surfactant ◽  
Cetyltrimethylammonium Bromide ◽  
Mesoporous Silica Nanoparticles ◽  
Scale Up ◽  
Silica Nanospheres ◽  
Pore Structures ◽  
Mesoporous Silica Nanospheres

Mesoporous silica nanoparticles with varied morphologies and pore structures were synthesized on the kilogram scale using cetyltrimethylammonium bromide and an anionic surfactant as co-templates.

scholarly journals The Design of Anionic Surfactant-Based Amino-Functionalized Mesoporous Silica Nanoparticles and their Application in Transdermal Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1035
Author(s):  
Aliyah Almomen ◽  
Ahmed M. El-Toni ◽  
Mohammed Badran ◽  
Adel Alhowyan ◽  
Mohd Abul Kalam ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anionic Surfactant ◽  
Mesoporous Silica Nanoparticles ◽  
Synergetic Effect ◽  
Melanoma Cells ◽  
Skin Permeability ◽  
Loading Capacity ◽  
Structure Directing Agent ◽  
Functionalized Mesoporous Silica

Melanoma remains the most lethal form of skin cancer and most challenging to treat despite advances in the oncology field. Our work describes the utilization of nanotechnology to target melanoma locally in an attempt to provide an advanced and efficient quality of therapy. Amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were developed in situ through the utilization of anionic surfactant and different volumes of 3-aminopropyltriethoxysilane (APTES) as a co-structure directing agent (CSDA). Prepared particles were characterized for their morphology, particles size, 5-flurouracol (5-FU) and dexamethasone (DEX) loading capacity and release, skin penetration, and cytotoxicity in vitro in HT-144 melanoma cells. Results of transmission electron microscopy (TEM) and nitrogen adsorption–desorption isotherm showed that using different volumes of APTES during the functionalization process had an impact on the internal and external morphology of the particles, as well as particle size. However, changing the volume of APTES did not affect the diameter of formed mesochannels, which was about 4 nm. MSN-NH2 showed a relatively high loading capacity of 5-FU (12.6 ± 5.5) and DEX (44.72 ± 4.21) when using drug: MSN-NH2 ratios of 5:1 for both drugs. The release profile showed that around 83% of 5-FU and 21% of DEX were released over 48 h in pH 7.4. The skin permeability study revealed that enhancement ratio of 5-Fu and DEX using MSN-NH2 were 4.67 and 5.68, respectively, relative to their free drugs counterparts. In addition, the accumulation of drugs in skin layers where melanoma cells usually reside were enhanced approximately 10 times with 5-FU and 5 times with DEX when delivering drugs using MSN-NH2 compared to control. MSN-NH2 alone was nontoxic to melanoma cells when incubated for 48 h in the range of 0 to 468 µg/mL. The combination of 5-FU MSN-NH2 and DEX MSN-NH2 showed significant increase in toxicity compared to their free dug counterparts and exhibited a synergetic effect as well as the ability to circumvent DEX induced 5-FU resistance in melanoma cells.

scholarly journals Photo-redox activated drug delivery systems operating under two photon excitation in the near-IR

Nanoscale ◽  
2014 ◽  
Vol 6 (9) ◽  
pp. 4652-4658 ◽  
Author(s):  
Tania M. Guardado-Alvarez ◽  
Lekshmi Sudha Devi ◽  
Jean-Marie Vabre ◽  
Travis A. Pecorelli ◽  
Benjamin J. Schwartz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Design And Synthesis ◽  
Two Photon ◽  
Near Ir ◽  
Photon Excitation ◽  
Ir Light

We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by “snap-top” caps that are opened by near-IR light.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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