Raspberry anthocyanin consumption prevents diet-induced obesity by alleviating oxidative stress and modulating hepatic lipid metabolism

2018 ◽  
Vol 9 (4) ◽  
pp. 2112-2120 ◽  
Author(s):  
Tao Wu ◽  
Lu Yang ◽  
Xueqi Guo ◽  
Min Zhang ◽  
Rui Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Chronic Diseases ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Beneficial Effects ◽  
Diet Induced Obesity

Evidence indicates that raspberries have beneficial effects on chronic diseases.

Punicalagin improves hepatic lipid metabolism via modulation of oxidative stress and mitochondrial biogenesis in hyperlipidemic mice

2020 ◽  
Vol 11 (11) ◽  
pp. 9624-9633
Author(s):  
Ke Cao ◽  
Kexin Wang ◽  
Meng Yang ◽  
Xuyun Liu ◽  
Weiqiang Lv ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Function ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Beneficial Effects

Punicalagin (PU) from pomegranate exerts beneficial effects on acute hyperlipidemia-induced hepatic abnormalities via regulation of oxidative stress and mitochondrial function.

scholarly journals Radical Response: Effects of Heat Stress-Induced Oxidative Stress on Lipid Metabolism in the Avian Liver

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 35
Author(s):  
Nima K. Emami ◽  
Usuk Jung ◽  
Brynn Voy ◽  
Sami Dridi
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Lipid Metabolism ◽  
Egg Production ◽  
Well Being ◽  
Enzymatic Reactions ◽  
Poultry Production ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
The Impact

Lipid metabolism in avian species places unique demands on the liver in comparison to most mammals. The avian liver synthesizes the vast majority of fatty acids that provide energy and support cell membrane synthesis throughout the bird. Egg production intensifies demands to the liver as hepatic lipids are needed to create the yolk. The enzymatic reactions that underlie de novo lipogenesis are energetically demanding and require a precise balance of vitamins and cofactors to proceed efficiently. External stressors such as overnutrition or nutrient deficiency can disrupt this balance and compromise the liver’s ability to support metabolic needs. Heat stress is an increasingly prevalent environmental factor that impairs lipid metabolism in the avian liver. The effects of heat stress-induced oxidative stress on hepatic lipid metabolism are of particular concern in modern commercial chickens due to the threat to global poultry production. Chickens are highly vulnerable to heat stress because of their limited capacity to dissipate heat, high metabolic activity, high internal body temperature, and narrow zone of thermal tolerance. Modern lines of both broiler (meat-type) and layer (egg-type) chickens are especially sensitive to heat stress because of the high rates of mitochondrial metabolism. While this oxidative metabolism supports growth and egg production, it also yields oxidative stress that can damage mitochondria, cellular membranes and proteins, making the birds more vulnerable to other stressors in the environment. Studies to date indicate that oxidative and heat stress interact to disrupt hepatic lipid metabolism and compromise performance and well-being in both broilers and layers. The purpose of this review is to summarize the impact of heat stress-induced oxidative stress on lipid metabolism in the avian liver. Recent advances that shed light on molecular mechanisms and potential nutritional/managerial strategies to counteract the negative effects of heat stress-induced oxidative stress to the avian liver are also integrated.

scholarly journals Probiotics L. plantarum and L. curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet-Induced Obesity

Obesity ◽  
2013 ◽  
Vol 21 (12) ◽  
pp. 2571-2578 ◽  
Author(s):  
Sae-Rom Yoo ◽  
Young-Jae Kim ◽  
Do-Young Park ◽  
Un-Ju Jung ◽  
Seon-Min Jeon ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Diet Induced Obesity

scholarly journals Herbal Formula HT048 Attenuates Diet-Induced Obesity by Improving Hepatic Lipid Metabolism and Insulin Resistance in Obese Rats

Molecules ◽  
2016 ◽  
Vol 21 (11) ◽  
pp. 1424 ◽  
Author(s):  
Yoon Lee ◽  
Bora Jin ◽  
Sung Lee ◽  
MiKyung Song ◽  
HyeonHui Bae ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Metabolism ◽  
Herbal Formula ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Diet Induced Obesity ◽  
Obese Rats

scholarly journals Beneficial effects of Cinnamon on hepatic lipid metabolism are impaired in hypothyroid rats

2018 ◽  
Vol 50 ◽  
pp. 210-215 ◽  
Author(s):  
Bruna Pereira Lopes ◽  
Thaiane Gadioli Gaique ◽  
Luana Lopes Souza ◽  
Gabriela Silva Monteiro Paula ◽  
George E.G. Kluck ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Beneficial Effects

scholarly journals Blackberry and Blueberry Anthocyanin Supplementation Counteract High-Fat-Diet-Induced Obesity by Alleviating Oxidative Stress and Inflammation and Accelerating Energy Expenditure

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Tao Wu ◽  
Yufang Gao ◽  
Xueqi Guo ◽  
Min Zhang ◽  
Lingxiao Gong
Keyword(s):  
Oxidative Stress ◽  
Energy Expenditure ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Glutathione Metabolism ◽  
High Fat ◽  
Hepatic Lipid ◽  
Beneficial Effects ◽  
Low Fat Diet ◽  
Diet Induced Obesity

Many studies indicate that an anthocyanin-rich diet has beneficial effects preventing metabolic disease. In the present study, the molecular mechanism underlying the antiobesity effect of consuming blackberry anthocyanins (BLA) and blueberry anthocyanins (BBA) was investigated in high-fat-diet- (HFD-) fed C57BL/6 mice. Sixty mice were administered a low-fat diet (LFD), a HFD, or a HFD plus orlistat, and BLA or BBA in their daily food for 12 weeks. As a result, the consumption of BLA and BBA inhibited body weight gain by 40.5% and 55.4%, respectively, in HFD-fed mice. The BLA and BBA treatments markedly reduced serum and hepatic lipid levels and significantly increased hepatic superoxide dismutase and glutathione peroxidase activities. In addition, the treatments effectively increased fecal acetate and butyrate levels and significantly attenuated expression of tumor necrosis factor TNF-α, interleukin-6, and nuclear factor-kappaB genes. Moreover, gas chromatography time-of-flight mass spectroscopy results suggested that BLA and BBA significantly affected the hepatic lipid and glucose metabolic pathways, including glycerophospholipid metabolism, glutathione metabolism, and the insulin-signaling pathway. Therefore, BLA and BBA ameliorated diet-induced obesity by alleviating oxidative stress and inflammation and accelerating energy expenditure.

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