scholarly journals Probiotics L. plantarum and L. curvatus in Combination Alter Hepatic Lipid Metabolism and Suppress Diet-Induced Obesity

Obesity ◽  
2013 ◽  
Vol 21 (12) ◽  
pp. 2571-2578 ◽  
Author(s):  
Sae-Rom Yoo ◽  
Young-Jae Kim ◽  
Do-Young Park ◽  
Un-Ju Jung ◽  
Seon-Min Jeon ◽  
...  
Molecules ◽  
2016 ◽  
Vol 21 (11) ◽  
pp. 1424 ◽  
Author(s):  
Yoon Lee ◽  
Bora Jin ◽  
Sung Lee ◽  
MiKyung Song ◽  
HyeonHui Bae ◽  
...  

2018 ◽  
Vol 9 (4) ◽  
pp. 2112-2120 ◽  
Author(s):  
Tao Wu ◽  
Lu Yang ◽  
Xueqi Guo ◽  
Min Zhang ◽  
Rui Liu ◽  
...  

Evidence indicates that raspberries have beneficial effects on chronic diseases.


Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 823
Author(s):  
Wilfrid Mazier ◽  
Katy Le Corf ◽  
Ccori Martinez ◽  
Héloïse Tudela ◽  
Déborah Kissi ◽  
...  

Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae family have been proposed to act as keystones of the human gut ecosystem and to prevent adipogenesis. The objectives of the present study were to demonstrate the antiobesity potential of a new strain of Christensenella minuta in preclinical models and explore related mechanisms of action. The antiobesity potential of C. minuta DSM33407 was assessed in a diet-induced obesity mouse model. Changes in hepatic lipid metabolism were explored using targeted transcriptomics. Effects on gut microbiota were further assessed in a humanized Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) model inoculated with obese fecal samples. Shotgun metagenomics was applied to study microbial community structures in both models. C. minuta DSM33407 protected from diet-induced obesity and regulated associated metabolic markers such as glycemia and leptin. It also regulated hepatic lipid metabolism through a strong inhibition of de novo lipogenesis and maintained gut epithelial integrity. In the humanized SHIME® model, these effects were associated with modulations of the intestinal microbiota characterized by a decreased Firmicutes/Bacteroidetes ratio. These data indicate that C. minuta DSM33407 is a convincing therapeutic candidate for the management of obesity and associated metabolic disorders.


2001 ◽  
Vol 120 (5) ◽  
pp. A546-A546
Author(s):  
D SWARTZBASILE ◽  
M GOLDBLATT ◽  
C SVATEK ◽  
M WALTERS ◽  
S CHOI ◽  
...  

Author(s):  
Katarzyna Siemienowicz ◽  
Panagiotis Filis ◽  
Chiara Talia ◽  
Jennifer Thomas ◽  
Paul Fowler ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document