scholarly journals Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells

2017 ◽  
Vol 8 (8) ◽  
pp. 2905-2914 ◽  
Author(s):  
Francisco J. G. Muriana ◽  
Sergio Montserrat-de la Paz ◽  
Ricardo Lucas ◽  
Beatriz Bermudez ◽  
Sara Jaramillo ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Biological Activities ◽  
Human Endothelial Cells ◽  
Anti Inflammatory ◽  
Inflammatory Molecules

Novel biological activities for tyrosol metabolites on human endothelial cells.

scholarly journals Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 991
Author(s):  
Melanie S. Matos ◽  
José D. Anastácio ◽  
Cláudia Nunes dos Santos
Keyword(s):  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Physiological State ◽  
Plant Secondary Metabolites ◽  
Inflammatory Pathways ◽  
Inflammatory State ◽  
Anti Inflammatory ◽  
Inflammatory Molecules

Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage. Sesquiterpene lactones (SLs) are composed of a large and diverse group of highly bioactive plant secondary metabolites, characterized by a 15-carbon backbone structure. In recent years, the interest in SLs has risen due to their vast array of biological activities beneficial for human health. The anti-inflammatory potential of these compounds results from their ability to target and inhibit various key pro-inflammatory molecules enrolled in diverse inflammatory pathways, and prevent or reduce the inflammatory damage on tissues. Research on the anti-inflammatory mechanisms of SLs has thrived over the last years, and numerous compounds from diverse plants have been studied, using in silico, in vitro, and in vivo assays. Besides their anti-inflammatory potential, their cytotoxicity, structure–activity relationships, and pharmacokinetics have been investigated. This review aims to gather the most relevant results and insights concerning the anti-inflammatory potential of SL-rich extracts and pure SLs, focusing on their effects in different inflammatory pathways and on different molecular players.

scholarly journals The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells

2013 ◽  
Vol 1833 (6) ◽  
pp. 1553-1561 ◽  
Author(s):  
Renata P. Guedes ◽  
Eduardo Rocha ◽  
Jerome Mahiou ◽  
Herwig P. Moll ◽  
Maria B. Arvelo ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Human Endothelial Cells ◽  
Terminal Domain ◽  
Anti Inflammatory

Anti-Inflammatory Effects of Hyperoside in Human Endothelial Cells and in Mice

Inflammation ◽  
2014 ◽  
Vol 38 (2) ◽  
pp. 784-799 ◽  
Author(s):  
Sae-Kwang Ku ◽  
Wei Zhou ◽  
Wonhwa Lee ◽  
Min-Su Han ◽  
MinKyun Na ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Human Endothelial Cells ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory functions of purpurogallin in LPS-activated human endothelial cells

BMB Reports ◽  
2012 ◽  
Vol 45 (3) ◽  
pp. 200-205 ◽  
Author(s):  
Tae-Hoon Kim ◽  
Sae-Kwang Ku ◽  
In-Chul Lee ◽  
Jong-Sup Bae
Keyword(s):  
Endothelial Cells ◽  
Human Endothelial Cells ◽  
Anti Inflammatory

Antithrombotic and anti-inflammatory properties of rosuvastatin in cultured human endothelial cells

2005 ◽  
Vol 59 (s148) ◽  
pp. 3-13
Author(s):  
L. Mussoni ◽  
S. Colli ◽  
M. Brambilla ◽  
A. Banas ◽  
S. Eligini ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Human Endothelial Cells ◽  
Anti Inflammatory

Anti‐inflammatory effects of rhaponticin on LPS‐induced human endothelial cells through inhibition of MAPK/NF‐κβ signaling pathways

2021 ◽  
Author(s):  
Rougang Li ◽  
Arunachalam Chinnathambi ◽  
Sulaiman Ali Alharbi ◽  
Omar H. M. Shair ◽  
Vishnu Priya Veeraraghavan ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Signaling Pathways ◽  
Human Endothelial Cells ◽  
Anti Inflammatory

scholarly journals Anti-Inflammatory Effects of the Fraction from the Leaves of Pyrus pyrifolia on LPS-Stimulated THP-1 Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Gilhye Lee ◽  
Jung-Hee Kim ◽  
Hyun-Jae Jang ◽  
Ji-Won Park ◽  
Jae-Won Lee ◽  
...  
Keyword(s):  
East Asia ◽  
Biological Activities ◽  
Pyrus Pyrifolia ◽  
Rna Expression ◽  
Inflammatory Drug ◽  
Pyrus Pyrifolia Nakai ◽  
Tnf Α ◽  
Bioactive Fraction ◽  
Anti Inflammatory ◽  
Inflammatory Molecules

Pyrus pyrifolia Nakai (P. pyrifolia) has been traditionally used in East Asia to treat diseases such as phlegm, cough, hangover, and fever. However, there is no investigation that evaluates the biological activities of the leaves of P. pyrifolia. This study aims at describing the anti-inflammatory effects of PP, a bioactive fraction from the leaves of P. pyrifolia, in lipopolysaccharide (LPS)-stimulated THP-1 cells. Initially, PP decreased the protein and RNA expression of TNF-α, MCP-1, IL-8, and IL-6 induced by LPS. Moreover, PP attenuated the phosphorylation of p38, JNK, and ERK. In addition, after stimulation with LPS, the degradation of IκB-α was suppressed by PP, and the phosphorylation of IκB-α and p65 was suppressed by PP. Additionally, PP increased HO-1, which controls the production of inflammatory molecules, by activating Nrf2. These results indicated that PP could be used as an anti-inflammatory drug to promote wellness.

scholarly journals Apolipoprotein A-I mimetic 4F alters the function of human monocyte-derived macrophages

2010 ◽  
Vol 298 (6) ◽  
pp. C1538-C1548 ◽  
Author(s):  
Lesley E. Smythies ◽  
C. Roger White ◽  
Akhil Maheshwari ◽  
M. N. Palgunachari ◽  
G. M. Anantharamaiah ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Surface ◽  
Cholesterol Efflux ◽  
Human Monocyte ◽  
Cholesterol Depletion ◽  
Major Protein ◽  
Human Endothelial Cells ◽  
Functional Changes ◽  
Apolipoprotein A ◽  
Anti Inflammatory

HDL and its major protein component apolipoprotein A-I (apoA-I) exert anti-inflammatory effects, inhibit monocyte chemotaxis/adhesion, and reduce vascular macrophage content in inflammatory conditions. In this study, we tested the hypothesis that the apoA-I mimetic 4F modulates the function of monocyte-derived macrophages (MDMs) by regulating the expression of key cell surface receptors on MDMs. Primary human monocytes and THP-1 cells were treated with 4F, apoA-I, or vehicle for 7 days and analyzed for expression of cell surface markers, adhesion to human endothelial cells, phagocytic function, cholesterol efflux capacity, and lipid raft organization. 4F and apoA-I treatment decreased the expression of HLA-DR, CD86, CD11b, CD11c, CD14, and Toll-like receptor-4 (TLR-4) compared with control cells, suggesting the induction of monocyte differentiation. Both treatments abolished LPS-induced mRNA for monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 (MIP-1), regulated on activation, normal T-expressed and presumably secreted (RANTES), IL-6, and TNF-α but significantly upregulated LPS-induced IL-10 expression. Moreover, 4F and apoA-I induced a 90% reduction in the expression of CD49d, a ligand for the VCAM-1 receptor, with a concurrent decrease in monocyte adhesion (55% reduction) to human endothelial cells and transendothelial migration (34 and 27% for 4F and apoA-I treatments) compared with vehicle treatment. In addition, phagocytosis of dextran-FITC beads was inhibited by 4F and apoA-I, a response associated with reduced expression of CD32. Finally, 4F and apoA-I stimulated cholesterol efflux from MDMs, leading to cholesterol depletion and disruption of lipid rafts. These data provide evidence that 4F, similar to apoA-I, induces profound functional changes in MDMs, possibly due to differentiation to an anti-inflammatory phenotype.

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