Stabilization of a non-aqueous self-double-emulsifying delivery system of rutin by fat crystals and nonionic surfactants: preparation and bioavailability study

2017 ◽  
Vol 8 (7) ◽  
pp. 2512-2522 ◽  
Author(s):  
Qiang Wang ◽  
Juan Huang ◽  
Caibiao Hu ◽  
Nan Xia ◽  
Tong Li ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Bioavailability ◽  
Nonionic Surfactants ◽  
Emulsion Stability ◽  
Fat Crystals ◽  
Emulsifier System ◽  
Bioavailability Study

The use of a dual emulsifier system enhances emulsion stability and the non-aqueous SDEDS improves the oral bioavailability of rutin.

Improved antimicrobial activity and oral bioavailability of Delafloxacin by self-nanoemulsifying drug delivery system (SNEDDS)

2021 ◽  
pp. 102572
Author(s):  
Md. Khalid Anwer ◽  
Muzaffar Iqbal ◽  
Mohammed F. Aldawsari ◽  
Ahmed Alalaiwe ◽  
Muqtader Mohammad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability

scholarly journals Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability

2006 ◽  
Vol 7 (3) ◽  
Author(s):  
Pradip Kumar Ghosh ◽  
Rita J. Majithiya ◽  
Manish L. Umrethia ◽  
Rayasa S. R. Murthy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Design And Development

Influence of a mixed particle/surfactant emulsifier system on water-in-oil emulsion stability

2014 ◽  
Vol 457 ◽  
pp. 49-57 ◽  
Author(s):  
Alla Nesterenko ◽  
Audrey Drelich ◽  
Huiling Lu ◽  
Danièle Clausse ◽  
Isabelle Pezron
Keyword(s):  
Emulsion Stability ◽  
Oil Emulsion ◽  
Emulsifier System ◽  
Water In Oil Emulsion

scholarly journals Surface shear inviscidity of soluble surfactants

2014 ◽  
Vol 111 (10) ◽  
pp. 3677-3682 ◽  
Author(s):  
Zachary A. Zell ◽  
Arash Nowbahar ◽  
Vincent Mansard ◽  
L. Gary Leal ◽  
Suraj S. Deshmukh ◽  
...  
Keyword(s):  
Shear Viscosity ◽  
Nonionic Surfactants ◽  
Emulsion Stability ◽  
Foam Stability ◽  
Sensitivity Limit ◽  
Multiple Control ◽  
Surface Shear ◽  
Soluble Surfactants ◽  
Almost All ◽  
Surface Shear Viscosity

Foam and emulsion stability has long been believed to correlate with the surface shear viscosity of the surfactant used to stabilize them. Many subtleties arise in interpreting surface shear viscosity measurements, however, and correlations do not necessarily indicate causation. Using a sensitive technique designed to excite purely surface shear deformations, we make the most sensitive and precise measurements to date of the surface shear viscosity of a variety of soluble surfactants, focusing on SDS in particular. Our measurements reveal the surface shear viscosity of SDS to be below the sensitivity limit of our technique, giving an upper bound of order 0.01 μN·s/m. This conflicts directly with almost all previous studies, which reported values up to 103–104 times higher. Multiple control and complementary measurements confirm this result, including direct visualization of monolayer deformation, for SDS and a wide variety of soluble polymeric, ionic, and nonionic surfactants of high- and low-foaming character. No soluble, small-molecule surfactant was found to have a measurable surface shear viscosity, which seriously undermines most support for any correlation between foam stability and surface shear rheology of soluble surfactants.

Greatly enhanced oral bioavailability of propranolol using the HALOTM liver-bypass drug delivery system

1994 ◽  
pp. 306-309
Author(s):  
S.G. Barnwell ◽  
L. Gauci ◽  
R.J. Harris ◽  
D. Attwood ◽  
G. Littlewood ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability

scholarly journals Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable Self-Microemulsifying Drug Delivery System Containing Gelucire® 44/14

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 58 ◽  
Author(s):  
Dong Shin ◽  
Bo Chae ◽  
Yoon Goo ◽  
Ho Yoon ◽  
Chang Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Amorphous State ◽  
Poloxamer 407 ◽  
Enhanced Dissolution ◽  
Previous Formulation ◽  
Practical Development ◽  
Precipitation Inhibitor

To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but encountered a stability problem (Transcutol® P-induced weight loss in storage) after solidification. In the present study, replacing Transcutol® P with Gelucire® 44/14 resulted in a novel SuSMED formulation, wherein the total amount of surfactant/cosurfactant was less than that of the previous formulation. Solidified SuSMED (S-SuSMED) granules were prepared by blending VST-containing SuSMED with selective solid carriers, L-HPC and Florite® PS-10, wherein VST existed in an amorphous state. S-SuSMED tablets fabricated by direct compression with additional excipients were sufficiently stable in terms of drug content and impurity changes after 6 months of storage at accelerated conditions (40 ± 2 °C and 75 ± 5% relative humidity). Consequently, enhanced dissolution was obtained (pH 1.2, 2 h): 6-fold for S-SuSMED granules against raw VST; 2.3-fold for S-SuSMED tablets against Diovan® (reference tablet). S-SuSMED tablets increased oral bioavailability in rats (10 mg/kg VST dose): approximately 177–198% versus raw VST and Diovan®. Therefore, VST-loaded S-SuSMED formulations might be good candidates for practical development in the pharmaceutical industry.

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