scholarly journals Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability

2006 ◽  
Vol 7 (3) ◽  
Author(s):  
Pradip Kumar Ghosh ◽  
Rita J. Majithiya ◽  
Manish L. Umrethia ◽  
Rayasa S. R. Murthy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Design And Development

Improved antimicrobial activity and oral bioavailability of Delafloxacin by self-nanoemulsifying drug delivery system (SNEDDS)

2021 ◽  
pp. 102572
Author(s):  
Md. Khalid Anwer ◽  
Muzaffar Iqbal ◽  
Mohammed F. Aldawsari ◽  
Ahmed Alalaiwe ◽  
Muqtader Mohammad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antimicrobial Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability

Design and development of paliperidone mesoporous silica template as a platform for surge dose drug delivery system

2018 ◽  
Vol 34 (3) ◽  
pp. 117-125 ◽  
Author(s):  
Vishal Vijay Pande ◽  
Komal Sadashiv Jadhav ◽  
Mahendra Ashok Giri ◽  
Prakash Namdeo Kendre ◽  
Somanth Kedarling Vibhute ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Design And Development ◽  
Silica Template

Greatly enhanced oral bioavailability of propranolol using the HALOTM liver-bypass drug delivery system

1994 ◽  
pp. 306-309
Author(s):  
S.G. Barnwell ◽  
L. Gauci ◽  
R.J. Harris ◽  
D. Attwood ◽  
G. Littlewood ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability

scholarly journals Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable Self-Microemulsifying Drug Delivery System Containing Gelucire® 44/14

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 58 ◽  
Author(s):  
Dong Shin ◽  
Bo Chae ◽  
Yoon Goo ◽  
Ho Yoon ◽  
Chang Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Bioavailability ◽  
Amorphous State ◽  
Poloxamer 407 ◽  
Enhanced Dissolution ◽  
Previous Formulation ◽  
Practical Development ◽  
Precipitation Inhibitor

To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P (cosurfactant), and Poloxamer 407 (precipitation inhibitor) but encountered a stability problem (Transcutol® P-induced weight loss in storage) after solidification. In the present study, replacing Transcutol® P with Gelucire® 44/14 resulted in a novel SuSMED formulation, wherein the total amount of surfactant/cosurfactant was less than that of the previous formulation. Solidified SuSMED (S-SuSMED) granules were prepared by blending VST-containing SuSMED with selective solid carriers, L-HPC and Florite® PS-10, wherein VST existed in an amorphous state. S-SuSMED tablets fabricated by direct compression with additional excipients were sufficiently stable in terms of drug content and impurity changes after 6 months of storage at accelerated conditions (40 ± 2 °C and 75 ± 5% relative humidity). Consequently, enhanced dissolution was obtained (pH 1.2, 2 h): 6-fold for S-SuSMED granules against raw VST; 2.3-fold for S-SuSMED tablets against Diovan® (reference tablet). S-SuSMED tablets increased oral bioavailability in rats (10 mg/kg VST dose): approximately 177–198% versus raw VST and Diovan®. Therefore, VST-loaded S-SuSMED formulations might be good candidates for practical development in the pharmaceutical industry.

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