scholarly journals Vanadium(v) oxoanions in basic water solution: a simple oxidative system for the one pot selective conversion ofl-proline to pyrroline-2-carboxylate

2017 ◽  
Vol 46 (43) ◽  
pp. 15059-15069 ◽  
Author(s):  
Lorenzo Biancalana ◽  
Giada Tuci ◽  
Fabio Piccinelli ◽  
Fabio Marchetti ◽  
Marco Bortoluzzi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Water Solution ◽  
Water Medium ◽  
One Pot ◽  
Selective Conversion ◽  
The One ◽  
Oxidative System

The unusual, one pot conversion ofl-proline to pyrroline-2-carboxylate, using simple V(v) species (NH4VO3or V2O5) as oxidants in basic water medium, is described. No reaction was observed with primary and tertiary α-amino acids.

scholarly journals A Water-Soluble Copper-Immobilized Covalent Organic Framework Functioning as an “OFF–ON” Fluorescent Sensor for Amino Acids

2021 ◽  
Author(s):  
Lamiaa Reda Ahmed ◽  
Ahmed F. M. EL-Mahdy ◽  
Cheng-Tang Pan ◽  
Shiao-Wei Kuo
Keyword(s):  
Amino Acids ◽  
Fluorescent Sensor ◽  
Water Soluble ◽  
One Pot ◽  
Covalent Organic Framework ◽  
The One ◽  
Organic Framework

In this paper, we describe the construction of a new fluorescent hydroxyl- and hydrazone-based covalent organic framework (TFPB-DHTH COF) through the one-pot polycondensation of 1,3,5-tris(4-formylphenyl)benzene (TFPB) and 2,5-dihydroxyterephthalohydrazide (DHTH) under...

One-pot selective conversion of C5-furan into 1,4-pentanediol over bulk Ni–Sn alloy catalysts in an ethanol/H2O solvent mixture

2019 ◽  
Vol 21 (9) ◽  
pp. 2307-2315 ◽  
Author(s):  
Rodiansono Rodiansono ◽  
Maria Dewi Astuti ◽  
Takayoshi Hara ◽  
Nobuyuki Ichikuni ◽  
Shogo Shimazu
Keyword(s):  
Solvent Mixture ◽  
Hydrogen Gas ◽  
One Pot ◽  
Selective Conversion ◽  
The One ◽  
Alloy Catalysts

The synergistic actions between an inexpensive bulk Ni–Sn(1.5) alloy, hydrogen gas, and an ethanol/H2O solvent mixture selectively assisted the one pot conversion of C5-furan compounds to 1,4-pentanediol with outstanding yields up to 92%.

One-pot total synthesis of streptindole, arsindoline B and their congeners through tandem decarboxylative deaminative dual-coupling reaction of amino acids with indoles

2015 ◽  
Vol 13 (14) ◽  
pp. 4240-4247 ◽  
Author(s):  
Jiachen Xiang ◽  
Jungang Wang ◽  
Miao Wang ◽  
Xianggao Meng ◽  
Anxin Wu
Keyword(s):  
Amino Acids ◽  
Natural Products ◽  
Total Synthesis ◽  
Coupling Reaction ◽  
One Pot ◽  
The One

This paper described a decarboxylative deaminative dual-coupling reaction of amino acids with indoles to afford BIM scaffolds and its further application to the one-pot total synthesis of natural products.

scholarly journals A Facile and Catalyst-Free Microwave-Promoted Multicomponent Reaction for the Synthesis of Functionalised 1,4-Dihydropyridines With Superb Selectivity and Yields

2021 ◽  
Vol 9 ◽  
Author(s):  
Nagaraju Kerru ◽  
Suresh Maddila ◽  
Sreekantha B. Jonnalagadda
Keyword(s):  
Spectroscopic Analysis ◽  
High Selectivity ◽  
Water Medium ◽  
One Pot ◽  
Green Protocol ◽  
Catalyst Free ◽  
Active Methylene Compounds ◽  
The One ◽  
Pyrimidine Analogs ◽  
Active Methylene

We report a highly efficient green protocol for developing a novel library of 1,2,4-triazole-tagged 1,4-dihydropyridine analogs through the one-pot process from the four-component fusion of the 1H-1,2,4-triazol-3-amine with different chosen aldehydes, diethyl acetylenedicarboxylate, and active methylene compounds in a water medium under microwave irradiation and catalyst-free conditions. Excellent yields (94–97%) of the target products were achieved with high selectivity with a short reaction time (<12 min) at room temperature. The structures of the synthesized pyrimidine analogs were established by NMR and HRMS spectroscopic analysis. Simple workup, impressive yields, no column chromatography, green solvent, rapid reaction, and excellent functional group tolerance are the benefits of this protocol.

scholarly journals 2-Ketoglutarate-Generated In Vitro Enzymatic Biosystem Facilitates Fe(II)/2-Ketoglutarate-Dependent Dioxygenase-Mediated C–H Bond Oxidation for (2s,3r,4s)-4-Hydroxyisoleucine Synthesis

2020 ◽  
Vol 21 (15) ◽  
pp. 5347
Author(s):  
Xiao-Ran Jing ◽  
Huan Liu ◽  
Yao Nie ◽  
Yan Xu
Keyword(s):  
Amino Acids ◽  
Raw Materials ◽  
Cascade Reaction ◽  
Single Step ◽  
One Pot ◽  
Bond Functionalization ◽  
Hydroxy Amino ◽  
Enzymatic Systems ◽  
The One

Fe(II)/2-ketoglutarate-dependent dioxygenase (Fe(II)/2-KG DO)-mediated hydroxylation is a critical type of C–H bond functionalization for synthesizing hydroxy amino acids used as pharmaceutical raw materials and precursors. However, DO activity requires 2-ketoglutarate (2-KG), lack of which reduces the efficiency of Fe(II)/2-KG DO-mediated hydroxylation. Here, we conducted multi-enzymatic syntheses of hydroxy amino acids. Using (2s,3r,4s)-4-hydroxyisoleucine (4-HIL) as a model product, we coupled regio- and stereo-selective hydroxylation of l-Ile by the dioxygenase IDO with 2-KG generation from readily available l-Glu by l-glutamate oxidase (LGOX) and catalase (CAT). In the one-pot system, H2O2 significantly inhibited IDO activity and elevated Fe2+ concentrations of severely repressed LGOX. A sequential cascade reaction was preferable to a single-step process as CAT in the former system hydrolyzed H2O2. We obtained 465 mM 4-HIL at 93% yield in the two-step system. Moreover, this process facilitated C–H hydroxylation of several hydrophobic aliphatic amino acids to produce hydroxy amino acids, and C–H sulfoxidation of sulfur-containing l-amino acids to yield l-amino acid sulfoxides. Thus, we constructed an efficient cascade reaction to produce 4-HIL by providing prerequisite 2-KG from cheap and plentiful l-Glu and developed a strategy for creating enzymatic systems catalyzing 2-KG-dependent reactions in sustainable bioprocesses that synthesize other functional compounds.

Molecular diversity of the three-component reaction of α-amino acids, dialkyl acetylenedicarboxylates and N-substituted maleimides

2016 ◽  
Vol 14 (27) ◽  
pp. 6497-6507 ◽  
Author(s):  
Liang Chen ◽  
Jing Sun ◽  
Ju Xie ◽  
Chao-Guo Yan
Keyword(s):  
Amino Acids ◽  
Molecular Diversity ◽  
One Pot ◽  
Dialkyl Acetylenedicarboxylate ◽  
Dialkyl Acetylenedicarboxylates ◽  
Three Component Reaction ◽  
The One

The one-pot three-component reaction of secondary α-amino acids with dialkyl acetylenedicarboxylate and N-substituted maleimides afforded functionalized pyrrolo[3,4-a]pyrrolizines, pyrrolo[3′,4′:3,4]pyrrolo[1,2-c]thiazoles, pyrrolo[3,4-a]indolizines and octahydropyrrolo[3,4-c]pyrroles.

scholarly journals Study on the Synthesis of Some (Un)Substituted 2-Amino-4-aryl-7-hydroxy-4H-chromene-3-carbonitriles in the Water Medium

Proceedings ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 67
Author(s):  
Nguyen Dinh Thanh ◽  
Do Son Hai ◽  
Pham Thi Thu Hien ◽  
Vu Thi Ngoc Bich ◽  
Vu Ngoc Toan ◽  
...  
Keyword(s):  
Sodium Carbonate ◽  
Room Temperature ◽  
Sodium Carbonate Solution ◽  
Carbonate Solution ◽  
Simple Synthesis ◽  
Water Medium ◽  
One Pot ◽  
Three Component Reaction ◽  
Substituted Benzaldehydes ◽  
The One

An efficient and simple synthesis of substituted 2-amino-4H-chromene-3-carbonitriles was developed by the one-pot and three-component reaction of a mixture of corresponding substituted benzaldehydes, resorcinol, and malononitrile in the presence of sodium carbonate solution as a catalyst at room temperature.

A Series of Metal-Organic Frameworks for Selective CO2 Capture and Catalytic Oxidative Carboxylation of Olefins

2018 ◽  
Author(s):  
Huong T. D. Nguyen ◽  
Y B. N. Tran ◽  
Hung N. Nguyen ◽  
Tranh C. Nguyen ◽  
Felipe Gándara ◽  
...  
Keyword(s):  
Room Temperature ◽  
Gas Adsorption ◽  
New Materials ◽  
One Pot ◽  
Acid Gas ◽  
Naphthalene Diimide ◽  
Styrene Carbonate ◽  
Metal Organic ◽  
Adsorption Of Co ◽  
The One

<p>Three novel lanthanide metal˗organic frameworks (Ln-MOFs), namely MOF-590, -591, and -592 were constructed from a naphthalene diimide tetracarboxylic acid. Gas adsorption measurements of MOF-591 and -592 revealed good adsorption of CO<sub>2</sub> (low pressure, at room temperature) and moderate CO<sub>2</sub> selectivity over N<sub>2</sub> and CH<sub>4</sub>. Accordingly, breakthrough measurements were performed on a representative MOF-592, in which the separation of CO<sub>2</sub> from binary mixture containing N<sub>2</sub> and CO<sub>2</sub> was demonstrated without any loss in performance over three consecutive cycles. Moreover, MOF-590, MOF-591, and MOF-592 exhibited catalytic activity in the one-pot synthesis of styrene carbonate from styrene and CO<sub>2</sub> under mild conditions (1 atm CO<sub>2</sub>, 80 °C, and solvent-free). Among the new materials, MOF-590 revealed a remarkable efficiency with exceptional conversion (96%), selectivity (95%), and yield (91%). </p><br>

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