scholarly journals Arylboronate esters mediated self-healable and biocompatible dynamic G-quadruplex hydrogels as promising 3D-bioinks

2018 ◽  
Vol 54 (14) ◽  
pp. 1778-1781 ◽  
Author(s):  
Ankan Biswas ◽  
Sara Malferrari ◽  
Deepak M. Kalaskar ◽  
Apurba K. Das
Keyword(s):  
Molecular Weight ◽  
Cell Viability ◽  
Low Molecular Weight ◽  
Cell Distribution ◽  
High Cell ◽  
G Quadruplex ◽  
Homogeneous Cell

High cell viability and homogeneous cell distribution within extrudable low molecular weight self-healable G-quadruplex hydrogel make it as suitable 3D bioink.

scholarly journals Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera

Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 608
Author(s):  
Elena V. Girich ◽  
Anton N. Yurchenko ◽  
Olga F. Smetanina ◽  
Phan Thi Hoai Trinh ◽  
Ngo Thi Duy Ngoc ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Secondary Metabolites ◽  
Cell Viability ◽  
Chemical Structure ◽  
Aspergillus Terreus ◽  
Marine Fungi ◽  
2D Nmr ◽  
Natural Source ◽  
Low Molecular Weight ◽  
First Time

Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus, Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F (6) was thoroughly described for the first time. Anthraquinone (13) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone (1), 4-hydroxy-6-dehydroxyscytalone (2) and demethylcitreoviranol (3) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.

scholarly journals Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer

2021 ◽  
Author(s):  
Ching-Wen Huang ◽  
Yen-Cheng Chen ◽  
Tzu-Chieh Yin ◽  
Po-Jung Chen ◽  
Tsung-Kun Chang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Molecular Weight ◽  
Cell Viability ◽  
Signaling Pathway ◽  
Complementary Therapy ◽  
In Vivo Studies ◽  
Low Molecular Weight ◽  
Tumor Cell Migration ◽  
Anti Cancer

This study investigated the roles of low-molecular-weight fucoidan (LMWF) in enhancing the anti-cancer effects of fluoropyrimidine-based chemotherapy. HCT116 and Caco-2 cells were treated with LMWF and 5-FU. Cell viability, cell cycle, apoptosis, and migration were analyzed in both cell types. Potential mechanisms underlying how LMWF enhances the anti-cancer effects of fluoropyrimidine-based chemotherapy were also explored. The cell viability of HCT116 and Caco-2 cells was significantly reduced after treatment with a LMWF-5-FU combination. In HCT116 cells, LMWF enhanced the suppressive effects of 5-FU on cell viability through the 1) induction of cell cycle arrest in the S phase and 2) late apoptosis mediated by the Jun-N-terminal kinase (JNK) signaling pathway. In Caco-2 cells, LMWF enhanced the suppressive effects of 5-FU on cell viability through both c-mesenchymal–epithelial transition (MET)/ Kirsten Rat Sarcoma virus (KRAS)/ extracellular signal-regulated kinase (ERK) and c-MET/ phosphatidyl-inositol 3-kinases (PI3K)/ protein kinase B (AKT) signaling pathways. Moreover, LMWF enhanced the suppressive effects of 5-FU on tumor cell migration through the c-MET/ matrix metalloproteinase (MMP)-2 signaling pathway in both HCT116 and Caco-2 cells. Our results demonstrated that LMWF is a potential complementary therapy for enhancing the efficacies of fluoropyrimidine-based chemotherapy in colorectal cancers (CRCs) with the wild-type or mutated KRAS gene through different mechanisms. However, in vivo studies and in clinical trials are required to validate the results of the present study.

Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA

2017 ◽  
Vol 15 (15) ◽  
pp. 3265-3275 ◽  
Author(s):  
M. Livendahl ◽  
J. Jamroskovic ◽  
M. Hedenström ◽  
T. Görlich ◽  
N. Sabouri ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Quadruplex Dna ◽  
Quadruplex Structure ◽  
G Quadruplex

Low molecular weight spirocycles efficiently stabilize G-quadruplex DNA without changing its structure by binding the top of the G-quadruplex structure.

scholarly journals Discovery of new G-quadruplex binding chemotypes

2014 ◽  
Vol 50 (8) ◽  
pp. 960-963 ◽  
Author(s):  
Stephan A. Ohnmacht ◽  
Ehsan Varavipour ◽  
Rupesh Nanjunda ◽  
Ingrida Pazitna ◽  
Gloria Di Vita ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Proliferative Activity ◽  
Low Molecular Weight ◽  
G Quadruplex

We report a novel furan-based low molecular weight chemotype with high G-quadruplex affinity and potent anti-proliferative activity.

Depletion of androgen receptor low molecular weight isoform reduces bladder tumor cell viability and induces apoptosis

2021 ◽  
Vol 504 ◽  
pp. 49-57 ◽  
Author(s):  
Kimberley Katleba ◽  
Alan P. Lombard ◽  
Maria-Malvina Tsamouri ◽  
Han Bit Baek ◽  
Kristine S. Nishida ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Androgen Receptor ◽  
Tumor Cell ◽  
Cell Viability ◽  
Bladder Tumor ◽  
Low Molecular Weight

Influence of surface chemistry on the formation of a protein corona on nanodiamonds

2019 ◽  
Vol 7 (21) ◽  
pp. 3383-3389 ◽  
Author(s):  
Alfonso E. Garcia-Bennett ◽  
Arun Everest-Dass ◽  
Irene Moroni ◽  
Ishan Das Rastogi ◽  
Lindsay M. Parker ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Molecular Weight ◽  
Surface Chemistry ◽  
Cell Viability ◽  
Reactive Oxygen ◽  
Protein Corona ◽  
Low Molecular Weight ◽  
Oxygen Species ◽  
Low Molecular Weight Proteins

The protein corona of nanodiamonds is dominated by low molecular weight proteins and is largely independent of surface chemistry. The pre-incubation of nanodiamonds in serum and the formation of a protein corona decrease the production of reactive oxygen species, increasing the cell viability of macrophages.

scholarly journals Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer

2021 ◽  
Vol 22 (15) ◽  
pp. 8041
Author(s):  
Ching-Wen Huang ◽  
Yen-Cheng Chen ◽  
Tzu-Chieh Yin ◽  
Po-Jung Chen ◽  
Tsung-Kun Chang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Molecular Weight ◽  
Cell Viability ◽  
Signaling Pathway ◽  
Complementary Therapy ◽  
In Vivo Studies ◽  
Low Molecular Weight ◽  
Tumor Cell Migration ◽  
Anti Cancer

This study investigated the roles of low-molecular-weight fucoidan (LMWF) in enhancing the anti-cancer effects of fluoropyrimidine-based chemotherapy. HCT116 and Caco-2 cells were treated with LMWF and 5-FU. Cell viability, cell cycle, apoptosis, and migration were analyzed in both cell types. Potential mechanisms underlying how LMWF enhances the anti-cancer effects of fluoropyrimidine-based chemotherapy were also explored. The cell viability of HCT116 and Caco-2 cells was significantly reduced after treatment with a LMWF-–5FU combination. In HCT116 cells, LMWF enhanced the suppressive effects of 5-FU on cell viability through the 1) induction of cell cycle arrest in the S phase and 2) late apoptosis mediated by the Jun-N-terminal kinase (JNK) signaling pathway. In Caco-2 cells, LMWF enhanced the suppressive effects of 5-FU on cell viability through both the c-mesenchymal–epithelial transition (MET)/Kirsten rat sarcoma virus (KRAS)/extracellular signal-regulated kinase (ERK) and the c-MET/phosphatidyl-inositol 3-kinases (PI3K)/protein kinase B (AKT) signaling pathways. Moreover, LMWF enhanced the suppressive effects of 5-FU on tumor cell migration through the c-MET/matrix metalloproteinase (MMP)-2 signaling pathway in both HCT116 and Caco-2 cells. Our results demonstrated that LMWF is a potential complementary therapy for enhancing the efficacies of fluoropyrimidine-based chemotherapy in colorectal cancers (CRCs) with the wild-type or mutated KRAS gene through different mechanisms. However, in vivo studies and in clinical trials are required in order to validate the results of the present study.

A high-performance oil-free backing pump for electron microscopes

1978 ◽  
Vol 36 (1) ◽  
pp. 110-111
Author(s):  
G.K.W. Balkau ◽  
E. Bez ◽  
J.L. Farrant
Keyword(s):  
Molecular Weight ◽  
Electron Microscope ◽  
Hot Spots ◽  
High Performance ◽  
Carbonaceous Material ◽  
Contamination Rate ◽  
Low Molecular Weight ◽  
Principal Source ◽  
Rotary Pumps ◽  
Electron Microscopes

The earliest account of the contamination of electron microscope specimens by the deposition of carbonaceous material during electron irradiation was published in 1947 by Watson who was then working in Canada. It was soon established that this carbonaceous material is formed from organic vapours, and it is now recognized that the principal source is the oil-sealed rotary pumps which provide the backing vacuum. It has been shown that the organic vapours consist of low molecular weight fragments of oil molecules which have been degraded at hot spots produced by friction between the vanes and the surfaces on which they slide. As satisfactory oil-free pumps are unavailable, it is standard electron microscope practice to reduce the partial pressure of organic vapours in the microscope in the vicinity of the specimen by using liquid-nitrogen cooled anti-contamination devices. Traps of this type are sufficient to reduce the contamination rate to about 0.1 Å per min, which is tolerable for many investigations.

Low-molecular-weight heparin in the prevention and treatment of thromboembolic disorders

1998 ◽  
Vol 1 (5) ◽  
pp. 166-174 ◽  
Author(s):  
Evelyn R Hermes De Santis ◽  
Betsy S Laumeister ◽  
Vidhu Bansal ◽  
Vandana Kataria ◽  
Preeti Loomba ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Prevention And Treatment
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