Oxidation–reductive coupling of alcohols catalyzed by oxo-vanadium complexes

2018 ◽  
Vol 54 (7) ◽  
pp. 790-793 ◽  
Author(s):  
Eric Steffensmeier ◽  
Kenneth M. Nicholas
Keyword(s):  
Allylic Alcohols ◽  
Vanadium Complexes ◽  
The Novel ◽  
Reductive Coupling

Oxo-vanadium complexes catalyze the novel oxidation–reductive coupling of benzylic and allylic alcohols.

Oxidation of 2-methylpyrroles with perchlorinated iron(III) metalloporphyrin catalysts: a versatile synthesis of symmetric and asymmetric dipyrromethanes

1998 ◽  
Vol 76 (10) ◽  
pp. 1467-1473 ◽  
Author(s):  
Veranja Karunaratne ◽  
David Dolphin
Keyword(s):  
Catalytic Oxidation ◽  
Allylic Alcohols ◽  
The Novel ◽  
Efficient Synthesis ◽  
Mild Conditions ◽  
Metalloporphyrin Catalysts

A variety of substituted 2-methylpyrroles (3-8) were oxidized using the metalloporphyrin catalysts iron(III) meso-tetra(2,6-dichloro-3-sulphonatophenyl)-β-octachloroporphyrin chloride 1 and iron(III) meso-tetra(2,6-dichlorophenyl)-β-octachloroporphyrin chloride 2 under very mild conditions. Treatment of the resulting allylic alcohols 3a-8a with α-free pyrroles 9 and 10 resulted in a very efficient synthesis of the corresponding dipyrromethanes 3b-8b and 3c-8c. Furthermore, the above allylic alcohols when treated with furfurylamine produced the novel (2-furylmethyl)-2-pyrrolylmethylamines 3d-8d.Key words: catalytic oxidation, metalloporphyrins, pyrroles, dipyrromethanes, polyhalogenated porphyrins.

Regioselective Reductive Coupling of Alkynes and Aldehydes Leading to Allylic Alcohols

2003 ◽  
Vol 5 (5) ◽  
pp. 653-655 ◽  
Author(s):  
Kazuhiko Takai ◽  
Shuji Sakamoto ◽  
Takahiko Isshiki
Keyword(s):  
Allylic Alcohols ◽  
Reductive Coupling

scholarly journals Cell-based Screening For Identification Of The Novel Vanadium Complexes With Multidirectional Activity Relative To The Cells And The Mechanisms Associated With Metabolic Disorders

2019 ◽  
Vol 4 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Grzegorz Kazek ◽  
Monika Głuch-Lutwin ◽  
Barbara Mordyl ◽  
Elżbieta Menaszek ◽  
Janusz Szklarzewicz ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Glucose Utilization ◽  
Strong Support ◽  
Vanadium Complexes ◽  
Vanadium Complex ◽  
The Novel ◽  
Vanadium Compounds ◽  
Selection Of ◽  
Methyl Analog

In this study, 110 newly synthesized vanadium complexes from different structural groups were screened in three cell-based models representing the main target tissues for anti-diabetic drugs. In glucose utilization in C2C12 myocyte experiments, 93% of vanadium complexes were shown to have equal or greater activity than bis(maltolato)oxovanadium(IV) (BMOV), the methyl analog of bis(ethylmaltolato)oxovanadium(IV) (BEOV) which has been tested in clinical trials. Moreover, 49% and 50% of these complexes were shown to have equal or greater activity than BMOV in lipid accumulation in 3T3-L1 adipocytes and insulin secretion in RINm5F beta cell experiments, respectively. These results were the basis for the selection of compounds for the subsequent steps in the characterization of anti-diabetic properties. This study provides strong support for the application of screening cell-based assays with a phenotypic approach for the discovery of novel anti-diabetic drugs from the vanadium complex class. This is especially desirable due to the multiple and not fully defined mechanisms of action vanadium compounds.

Mechanistic Features of the Oxidation–Reductive Coupling of Alcohols Catalyzed by Oxo-Vanadium Complexes

2018 ◽  
Vol 58 (1) ◽  
pp. 844-854 ◽  
Author(s):  
Eric Steffensmeier ◽  
Matthew T. Swann ◽  
Kenneth M. Nicholas
Keyword(s):  
Vanadium Complexes ◽  
Reductive Coupling
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