scholarly journals Dopamine coated Fe3O4 nanoparticles as enzyme mimics for the sensitive detection of bacteria

2017 ◽  
Vol 53 (91) ◽  
pp. 12306-12308 ◽  
Author(s):  
Shazia Mumtaz ◽  
Li-Sheng Wang ◽  
Syed Zajif Hussain ◽  
Muhammad Abdullah ◽  
Zille Huma ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Sensitive Detection ◽  
Oxide Nanoparticles ◽  
Enzyme Mimics ◽  
Colorimetric Sensing

Colorimetric sensing of bacteria using dopamine-functionalized iron oxide nanoparticles.

scholarly journals Solanum tuberosum extract mediated synthesis and characterization of iron oxide nanoparticles for their antibacterial and antioxidant activity

2019 ◽  
Vol 9 (1-s) ◽  
pp. 5-15
Author(s):  
GC Madhu ◽  
Kannaiyan Jaianand ◽  
K Rameshkumar ◽  
Muthukumarasamy Eyini ◽  
Paulraj Balaji ◽  
...  
Keyword(s):  
Solanum Tuberosum ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
High Performance ◽  
Biological Synthesis ◽  
Oxide Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
Efficient Route

In the present study, the potential of aqueous extract of Solanum tuberosum for synthesis of Iron Oxide nanoparticles (Fe3O4) was evaluated. An eco-friendly synthesis of iron oxide nanoparticles and characteristics of the obtained Fe3O4 nanoparticles were studied using Ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform Infra-Red Spectroscopy (FTIR), Scanning Electron Microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-Ray Diffraction (XRD) and High Performance Liquid Chromatography (HPLC). The synthesized Iron oxide nanoparticles were effectively utilized for the antibacterial activity and antioxidant studies. The rapid biological synthesis of iron oxide nanoparticles using the extract of S. tuberosum provides an environment friendly, simple and efficient route. From the results, it is suggested that synthesized Iron Oxide could be used effective in future biomedical engineering. Keywords: Antibacterial, Antioxidant, Iron oxide (Fe3O4) nanoparticles, Solanum tuberosum.

Effects of biological buffer solutions on the peroxidase-like catalytic activity of Fe3O4 nanoparticles

Nanoscale ◽  
2019 ◽  
Vol 11 (39) ◽  
pp. 18393-18406 ◽  
Author(s):  
Mariana Raineri ◽  
Elin L. Winkler ◽  
Teobaldo E. Torres ◽  
Marcelo Vasquez Mansilla ◽  
Marcela S. Nadal ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Fe3o4 Nanoparticles ◽  
Oxide Nanoparticles ◽  
Toxicological Effects ◽  
Buffer Solutions

Biological buffering solutions need to be carefully considered when evaluating iron oxide nanoparticles (IONP) catalytic activity and their potential toxicological effects, because buffer species can interact with the surface of the particles.

scholarly journals Dual-Functional Iron Oxide Nanoparticles Coated with Polyvinyl Alcohol/5-Fluorouracil/Zinc-Aluminium-Layered Double Hydroxide for a Simultaneous Drug and Target Delivery System

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 855
Author(s):  
Mona Ebadi ◽  
Saifullah Bullo ◽  
Kalaivani Buskaran ◽  
Mohd Zobir Hussein ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Polyvinyl Alcohol ◽  
Iron Oxide Nanoparticles ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Fe3o4 Nanoparticles ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Double Hydroxide

Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized Fe3O4 nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare Fe3O4 nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment.

TARGETING CYCLIN B1 WITH ANTISENSE OLIGONUCLETOTIDES- COATED SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (10) ◽  
Author(s):  
Hosam Zaghloul ◽  
Doaa A. Shahin ◽  
Ibrahim El- Dosoky ◽  
Mahmoud E. El-awady ◽  
Fardous F. El-Senduny ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cellular Uptake ◽  
Superparamagnetic Iron Oxide ◽  
Cyclin B1 ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Mcf7 Cells ◽  
M Phase ◽  
The Impact

Antisense oligonucleotides (ASO) represent an attractive trend as specific targeting molecules but sustain poor cellular uptake meanwhile superparamagnetic iron oxide nanoparticles (SPIONs) offer stability of ASO and improved cellular uptake. In the present work we aimed to functionalize SPIONs with ASO targeting the mRNA of Cyclin B1 which represents a potential cancer target and to explore its anticancer activity. For that purpose, four different SPIONs-ASO conjugates, S-M (1–4), were designated depending on the sequence of ASO and constructed by crosslinking carboxylated SPIONs to amino labeled ASO. The impact of S-M (1–4) on the level of Cyclin B1, cell cycle, ROS and viability of the cells were assessed by flowcytometry. The results showed that S-M3 and S-M4 reduced the level of Cyclin B1 by 35 and 36%, respectively. As a consequence to downregulation of Cyclin B1, MCF7 cells were shown to be arrested at G2/M phase (60.7%). S-M (1–4) led to the induction of ROS formation in comparison to the untreated control cells. Furthermore, S-M (1–4) resulted in an increase in dead cells compared to the untreated cells and SPIONs-treated cells. In conclusion, targeting Cyclin B1 with ASO-coated SPIONs may represent a specific biocompatible anticancer strategy.

Ferrozine Assay for Simple and Cheap Iron Analysis of Silica-Coated Iron Oxide Nanoparticles

2018 ◽  
Author(s):  
Hattie Ring ◽  
Zhe Gao ◽  
Nathan D. Klein ◽  
Michael Garwood ◽  
John C. Bischof ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hydrofluoric Acid ◽  
Inductively Coupled Plasma ◽  
Silica Shell ◽  
Oxide Nanoparticles ◽  
Inductively Coupled ◽  
Digestion Process ◽  
Plasma Methods ◽  
Iron Analysis

The Ferrozinen assay is applied as an accurate and rapid method to quantify the iron content of iron oxide nanoparticles (IONPs) and can be used in biological matrices. The addition of ascorbic aqcid accelerates the digestion process and can penetrate an IONP core within a mesoporous and solid silica shell. This new digestion protocol avoids the need for hydrofluoric acid to digest the surrounding silica shell and provides and accessible alternative to inductively coupled plasma methods. With the updated digestion protocol, the quantitative range of the Ferrozine assay is 1 - 14 ppm. <br>

Ferrozine Assay for Simple and Cheap Iron Analysis of Silica-Coated Iron Oxide Nanoparticles

2018 ◽  
Author(s):  
Hattie Ring ◽  
Zhe Gao ◽  
Nathan D. Klein ◽  
Michael Garwood ◽  
John C. Bischof ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hydrofluoric Acid ◽  
Inductively Coupled Plasma ◽  
Silica Shell ◽  
Oxide Nanoparticles ◽  
Inductively Coupled ◽  
Digestion Process ◽  
Plasma Methods ◽  
Iron Analysis

The Ferrozinen assay is applied as an accurate and rapid method to quantify the iron content of iron oxide nanoparticles (IONPs) and can be used in biological matrices. The addition of ascorbic aqcid accelerates the digestion process and can penetrate an IONP core within a mesoporous and solid silica shell. This new digestion protocol avoids the need for hydrofluoric acid to digest the surrounding silica shell and provides and accessible alternative to inductively coupled plasma methods. With the updated digestion protocol, the quantitative range of the Ferrozine assay is 1 - 14 ppm. <br>

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