scholarly journals Dual-Functional Iron Oxide Nanoparticles Coated with Polyvinyl Alcohol/5-Fluorouracil/Zinc-Aluminium-Layered Double Hydroxide for a Simultaneous Drug and Target Delivery System

Polymers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 855
Author(s):  
Mona Ebadi ◽  
Saifullah Bullo ◽  
Kalaivani Buskaran ◽  
Mohd Zobir Hussein ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Polyvinyl Alcohol ◽  
Iron Oxide Nanoparticles ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Fe3o4 Nanoparticles ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Double Hydroxide

Iron oxide nanoparticles are suitable for biomedical applications owing to their ability to anchor to various active agents and drugs, unique magnetic properties, nontoxicity, and biocompatibility. In this work, the physico-chemical and magnetic properties, as well as the cytotoxicity, of Fe3O4 nanoparticles coated with a polymeric carrier and loaded with a 5-fluorouracil (5-FU) anti-cancer drug are discussed. The synthesized Fe3O4 nanoparticles were coated with polyvinyl alcohol and Zn/Al-layered double hydroxide as the drug host. The XRD, DTA/TG, and FTIR analyzes confirmed the presence of the coating layer on the surface of nanoparticles. The results showed a decrease in saturation magnetization of bare Fe3O4 nanoparticles after coating with the PVA/5FU/Zn/Al-LDH layer. In addition, the presence of the coating prevented the agglomeration of nanoparticles. Furthermore, the pseudo-second-order equation governed the kinetics of drug release. Finally, the coated nanoparticles showed stronger activity against liver cancer cells (HepG2) compared to that of the naked 5-FU drug, and displayed no cytotoxicity towards 3T3 fibroblast cell lines. The results of the present study demonstrate the potential of a nano delivery system for cancer treatment.

scholarly journals Correction: Resistive switching effect and magnetic properties of iron oxide nanoparticles embedded-polyvinyl alcohol film

RSC Advances ◽  
2020 ◽  
Vol 10 (28) ◽  
pp. 16526-16526
Author(s):  
Hai Hung Nguyen ◽  
Hanh Kieu Thi Ta ◽  
Sungkyun Park ◽  
Thang Bach Phan ◽  
Ngoc Kim Pham
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Polyvinyl Alcohol ◽  
Iron Oxide Nanoparticles ◽  
Resistive Switching ◽  
Oxide Nanoparticles ◽  
Switching Effect ◽  
Polyvinyl Alcohol Film ◽  
Resistive Switching Effect

Correction for ‘Resistive switching effect and magnetic properties of iron oxide nanoparticles embedded-polyvinyl alcohol film’ by Hai Hung Nguyen et al., RSC Adv., 2020, 10, 12900–12907.

Magnetic properties of polyvinyl alcohol-based composites containing iron oxide nanoparticles

1999 ◽  
Vol 9 (3) ◽  
pp. 87-93 ◽  
Author(s):  
D. Yu. Godovsky ◽  
A. V. Varfolomeev ◽  
G. D. Efremova ◽  
V. M. Cherepanov ◽  
G. A. Kapustin ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Polyvinyl Alcohol ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Magnetic Properties of Polyvinyl Alcohol and Doxorubicine Loaded Iron Oxide Nanoparticles for Anticancer Drug Delivery Applications

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0158084 ◽  
Author(s):  
Muhammad Nadeem ◽  
Munir Ahmad ◽  
Muhammad Saeed Akhtar ◽  
Amiruddin Shaari ◽  
Saira Riaz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Properties ◽  
Iron Oxide ◽  
Polyvinyl Alcohol ◽  
Iron Oxide Nanoparticles ◽  
Anticancer Drug ◽  
Oxide Nanoparticles ◽  
Anticancer Drug Delivery ◽  
Drug Delivery Applications

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

Comparative study on the magnetic properties of iron oxide nanoparticles loaded on mesoporous silica and carbon materials with different structure

2009 ◽  
Vol 121 (1-3) ◽  
pp. 178-184 ◽  
Author(s):  
Sher Alam ◽  
Chokkalingam Anand ◽  
Radhakrishnan Logudurai ◽  
Veerappan V. Balasubramanian ◽  
Katsuhiko Ariga ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Mesoporous Silica ◽  
Comparative Study ◽  
Iron Oxide Nanoparticles ◽  
Carbon Materials ◽  
Oxide Nanoparticles

Photo-fluorescent and magnetic properties of iron oxide nanoparticles for biomedical applications

Nanoscale ◽  
2015 ◽  
Vol 7 (18) ◽  
pp. 8209-8232 ◽  
Author(s):  
Donglu Shi ◽  
M. E. Sadat ◽  
Andrew W. Dunn ◽  
David B. Mast
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Physical Properties ◽  
Iron Oxide Nanoparticles ◽  
Basic Science ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Nanometer Range

Iron oxide exhibits fascinating physical properties especially in the nanometer range, not only from the standpoint of basic science, but also for a variety of engineering, particularly biomedical applications.

Sign in / Sign up

Export Citation Format

Share Document