Chiral crotyl geminal bis(silane): a useful reagent for asymmetric Sakurai allylation by selective desilylation-enabled chirality transfer

2017 ◽  
Vol 53 (21) ◽  
pp. 3078-3081 ◽  
Author(s):  
Zhiwen Chu ◽  
Kai Wang ◽  
Lu Gao ◽  
Zhenlei Song
Keyword(s):  
Enantioselective Synthesis ◽  
Prins Cyclization ◽  
One Pot ◽  
Chirality Transfer

Enantioselective synthesis of SiMe3/SiPh2Me-substituted crotyl geminal bis(silane) has been developed. This compound is a useful reagent for Ph3C+B(C6F5)4−-catalyzed asymmetric Sakurai allylation and one-pot Sakurai allylation/Prins cyclization processes. Chemoselective desilylation of SiPh2Me leads to efficient chirality transfer.

An Efficient Organocatalysis: A One-Pot Highly Enantioselective Synthesis of α-Aminophosphonates

2013 ◽  
Vol 2013 (24) ◽  
pp. 5509-5516 ◽  
Author(s):  
Prashant B. Thorat ◽  
Santosh V. Goswami ◽  
Rupali L. Magar ◽  
Bhagwan R. Patil ◽  
Sudhakar R. Bhusare
Keyword(s):  
Enantioselective Synthesis ◽  
One Pot

Cerium(IV) sulfate catalyzed one-pot three-component diastereo selective synthesis of 4-amidotetrahydropyrans

2009 ◽  
Vol 87 (6) ◽  
pp. 698-705 ◽  
Author(s):  
Nagarajan Panneer Selvam ◽  
Paramasivan T. Perumal
Keyword(s):  
Ritter Reaction ◽  
Selective Synthesis ◽  
Prins Cyclization ◽  
One Pot ◽  
One Pot Synthesis ◽  
Simple Protocol

A convenient and diastereoselective one-pot synthesis of cis-4-amidotetrahydropyrans is described. This simple protocol involves Prins cyclization of homoallylic alcohol and aldehydes, followed by Ritter reaction of acetonitrile leading to the formation of cis-4-acetamidopyrans in good yields.

scholarly journals One-pot synthesis of (R)-convolutamydine A involving in situ chiral organocatalyst formation

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
Shengwei Wei ◽  
Bernhard Schmid ◽  
Fliur Z. Macaev ◽  
Serghei N. Curlat ◽  
Andrei V. Malkov ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Synthetic Strategy

Abstract The application of a convenient one-pot synthetic strategy, utilizing an in situ formed organocatalyst, to the enantioselective synthesis of anti-leukaemia agent (R)-convolutamydine A has been demonstrated.

scholarly journals Intramolecular asymmetric reductive amination: synthesis of enantioenriched dibenz[c,e]azepines

2019 ◽  
Vol 10 (8) ◽  
pp. 2473-2477 ◽  
Author(s):  
Tao Yang ◽  
Xiaochong Guo ◽  
Qin Yin ◽  
Xumu Zhang
Keyword(s):  
Reductive Amination ◽  
Enantioselective Synthesis ◽  
One Pot

An enantioselective synthesis of dibenz[c,e]azepines containing both central and axial chiralities through a one pot N-Boc deprotection/intramolecular asymmetric reductive amination sequence has been achieved with generally excellent enantiocontrol (up to 97% ee).

scholarly journals One-Pot Catalytic Enantioselective Synthesis of 2-Pyrazolines

2019 ◽  
Vol 131 (8) ◽  
pp. 2491-2495 ◽  
Author(s):  
Connor J. Thomson ◽  
David M. Barber ◽  
Darren J. Dixon
Keyword(s):  
Enantioselective Synthesis ◽  
One Pot

scholarly journals One-Pot Lipase-Catalyzed Enantioselective Synthesis of (R)-(−)-N-Benzyl-3-(benzylamino)butanamide: The Effect of Solvent Polarity on Enantioselectivity

Molecules ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 2189 ◽  
Author(s):  
Marina Ortega-Rojas ◽  
José Rivera-Ramírez ◽  
C. Ávila-Ortiz ◽  
Eusebio Juaristi ◽  
Fernando González-Muñoz ◽  
...  
Keyword(s):  
Solvent Polarity ◽  
Enantioselective Synthesis ◽  
One Pot ◽  
Effect Of Solvent
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