scholarly journals Multicellular tumor invasion and plasticity in biomimetic materials

2017 ◽  
Vol 5 (8) ◽  
pp. 1460-1479 ◽  
Author(s):  
Susan E. Leggett ◽  
Amanda S. Khoo ◽  
Ian Y. Wong
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Tumor Invasion ◽  
Ex Vivo ◽  
Cancer Cell Invasion ◽  
Biomimetic Materials ◽  
Microfabricated Devices

Collective and individual cancer cell invasion can be investigatedin vitroandex vivousing microfabricated devices and hydrogels.

Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro

2007 ◽  
Vol 255 (1) ◽  
pp. 57-70 ◽  
Author(s):  
Anske Van den Abbeele ◽  
Veerle De Corte ◽  
Katrien Van Impe ◽  
Erik Bruyneel ◽  
Ciska Boucherie ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion

scholarly journals 3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo

2003 ◽  
Vol 88 (7) ◽  
pp. 1111-1118 ◽  
Author(s):  
I Kempen ◽  
D Papapostolou ◽  
N Thierry ◽  
L Pochet ◽  
S Counerotte ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Tumour Growth ◽  
Cancer Cell Invasion

scholarly journals GSK3β mediates pancreatic cancer cell invasion in vitro via the CXCR4/MMP-2 Pathway

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Xu Ying ◽  
Li Jing ◽  
Shijie Ma ◽  
Qianjun Li ◽  
Xiaoling Luo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro

2015 ◽  
Vol 113 (5) ◽  
pp. 738-746 ◽  
Author(s):  
Wenqing Cao ◽  
Jeffrey H Peters ◽  
Dylan Nieman ◽  
Meenal Sharma ◽  
Thomas Watson ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Oesophageal Adenocarcinoma ◽  
Cancer Cell Invasion ◽  
Node Metastasis

scholarly journals A new biomimetic assay reveals the temporal role of matrix stiffening in cancer cell invasion

2018 ◽  
Vol 29 (25) ◽  
pp. 2979-2988 ◽  
Author(s):  
Ralitza Staneva ◽  
Federica Burla ◽  
Gijsje H. Koenderink ◽  
Stéphanie Descroix ◽  
Danijela Matic Vignjevic ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Early Stage ◽  
In Vitro Models ◽  
Surrounding Tissue ◽  
Cancer Cell Invasion ◽  
Temporal Dimension ◽  
Vitro Assay

Tumor initiation and growth is associated with significant changes in the surrounding tissue. During carcinoma progression, a global stiffening of the extracellular matrix is observed and is interpreted as a signature of aggressive invasive tumors. However, it is still unknown whether this increase in matrix rigidity promotes invasion and whether this effect is constant along the course of invasion. Here we have developed a biomimetic in vitro assay that enabled us to address the question of the importance of tissue rigidity in the chronology of tumor invasion. Using low concentrations of the sugar threose, we can effectively stiffen reconstituted collagen I matrices and control the stiffening in time with no direct effect on residing cells. Our findings demonstrate that, depending on the timing of its stiffening, the extracellular matrix could either inhibit or promote cancer cell invasion and subsequent metastasis: while matrix stiffening after the onset of invasion promotes cancer cell migration and tumor spreading, stiff matrices encapsulate the tumor at an early stage and prevent cancer cell invasion. Our study suggests that adding a temporal dimension in in vitro models to analyze biological processes in four dimensions is necessary to fully capture their complexity.

scholarly journals Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

2015 ◽  
Vol 14 (1) ◽  
Author(s):  
Diego Iglesias-Gato ◽  
Yin-Choy Chuan ◽  
Ning Jiang ◽  
Charlotte Svensson ◽  
Jing Bao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Prostate Cancer Cell ◽  
Cancer Cell Invasion

scholarly journals Cancer-Associated Fibroblasts Differentiated by Exosomes Isolated from Cancer Cells Promote Cancer Cell Invasion

2020 ◽  
Vol 21 (21) ◽  
pp. 8153
Author(s):  
Kimin Kim ◽  
Yeh Joo Sohn ◽  
Ruri Lee ◽  
Hye Ju Yoo ◽  
Ji Yoon Kang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cell Types ◽  
Cancer Drug ◽  
Cancer Microenvironment ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion

Cancer-associated fibroblasts (CAFs) in the cancer microenvironment play an essential role in metastasis. Differentiation of endothelial cells into CAFs is induced by cancer cell-derived exosomes secreted from cancer cells that transfer molecular signals to surrounding cells. Differentiated CAFs facilitate migration of cancer cells to different regions through promoting extracellular matrix (ECM) modifications. However, in vitro models in which endothelial cells exposed to cancer cell-derived exosomes secreted from various cancer cell types differentiate into CAFs or a microenvironmentally controlled model for investigating cancer cell invasion by CAFs have not yet been studied. In this study, we propose a three-dimensional in vitro cancer cell invasion model for real-time monitoring of the process of forming a cancer invasion site through CAFs induced by exosomes isolated from three types of cancer cell lines. The invasiveness of cancer cells with CAFs induced by cancer cell-derived exosomes (eCAFs) was significantly higher than that of CAFs induced by cancer cells (cCAFs) through physiological and genetic manner. In addition, different genetic tendencies of the invasion process were observed in the process of invading cancer cells according to CAFs. Our 3D microfluidic platform helps to identify specific interactions among multiple factors within the cancer microenvironment and provides a model for cancer drug development.

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