scholarly journals Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasion in vitro

2015 ◽  
Vol 113 (5) ◽  
pp. 738-746 ◽  
Author(s):  
Wenqing Cao ◽  
Jeffrey H Peters ◽  
Dylan Nieman ◽  
Meenal Sharma ◽  
Thomas Watson ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Oesophageal Adenocarcinoma ◽  
Cancer Cell Invasion ◽  
Node Metastasis

ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis

2019 ◽  
Vol 121 (1) ◽  
pp. 231-243
Author(s):  
Ning Xu ◽  
Gen‐Yi Qu ◽  
Yu‐Peng Wu ◽  
Yun‐Zhi Lin ◽  
Dong‐Ning Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Bladder Cancer Cell ◽  
Cancer Cell Invasion ◽  
Node Metastasis

Paraneoplastic thrombocytosis is associated with increased mortality and increased rate of lymph node metastasis in oesophageal adenocarcinoma

Pathology ◽  
2017 ◽  
Vol 49 (5) ◽  
pp. 471-475 ◽  
Author(s):  
Agoston T. Agoston ◽  
Amitabh Srivastava ◽  
Yifan Zheng ◽  
Raphael Bueno ◽  
Robert D. Odze ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oesophageal Adenocarcinoma ◽  
Node Metastasis

scholarly journals Serum exosomal miR-4787-3p as potential lymph node metastasis and prognostic marker in esophageal squamous cell carcinoma.

2021 ◽  
Author(s):  
Shuang Liu ◽  
Zheng Lin ◽  
Jianwen Wang ◽  
Zerong Zheng ◽  
Wenqing Rao ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cox Regression ◽  
High Serum ◽  
Migration And Invasion ◽  
Cox Regression Analysis ◽  
Mirna Array ◽  
Node Metastasis

Abstract Background: To explore the miR-4787-3p expression levels in the serum exosome and tissue and its role in lymph node metastasis and prognosis in ESCC. Methods: The miRNA array was conducted to detect the ESCC serum exosomal miRNAs expression. A receiver operating characteristic (ROC) curve was constructed to determine the predictive ESCC with lymph node metastasis efficacy of serum exosomal miR-4784-3p. The Cox regression analysis was preformed to explore prognostic factors for ESCC. Transwell assay and CCK-8 assays were utilized to evaluate cell migration, invasion, and proliferation, respectively. Results: High serum exosomal miR-4787-3p expression was demonstrated in lymph node metastasis group (P =0.011). The serum exosomal miR-4787-3p expression was significantly associated with histologic grade (P = 0.010), and TNM stage (P = 0.033). However, there was no significant relationship between tissue miR-4787-3p expression and clinical characteristics (P >0.05). ROC analyses revealed that the AUCs of serum exosomal miR-4787-3p for lymph node metastasis prediction was 0.787. The Cox regression analysis found that high expression serum exosomal miR-4787-3p were correlated with poor prognoses (for OS, HR=2.68, 95% CI: 1.02~7.04; for DFS, HR = 2.65, 95% CI: 1.05~6.68). Nevertheless, no association between tissue miR-4787-3p expression and ESCC prognosis. In addition, upregulated expression of miR-4787-3p could promote migration and invasion in vitro. Conclusions: Serum exosomal miR-4787-3p can be promising biomarkers for ESCC metastasis and prognosis

scholarly journals Downregulation of PTPRK Promotes Cell Proliferation and Metastasis of NSCLC by Enhancing STAT3 Activation

2019 ◽  
Vol 2019 ◽  
pp. 1-7
Author(s):  
Xuting Xu ◽  
Dong Li ◽  
Jin Liu ◽  
Zhihong Ma ◽  
Huilian Huang ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tumor Suppressor ◽  
Cell Lines ◽  
Western Blotting ◽  
Invasion And Migration ◽  
Node Metastasis ◽  
Proliferation And Metastasis ◽  
And Migration

Objective. The receptor-type tyrosine-protein phosphatase κ (PTPRK) is a candidate tumor suppressor involved in the tumorigenesis of various organs. However, its expression and biological roles in non-small-cell lung cancer (NSCLC) have not yet been investigated. Methods. PTPRK expression in NSCLC tissues and cell lines was examined using real-time PCR and western blotting. In addition, the effects of PTPRK on cell migration, invasion, and proliferation were evaluated in vitro. Furthermore, we explored whether the downregulation of PTPRK led to STAT3 activation in NSCLC cell lines by western blotting. The expression of phospho-STAT3Tyr705 in primary human NSCLC tissues was evaluated by immunohistochemistry. Results. The results showed that PTPRK expression was frequently reduced in NSCLC tissues with lymph node metastasis and cell lines. The inhibition of PTPRK expression resulted in increased proliferation, invasion, and migration of NSCLC cells in vitro. Additionally, after silencing of PTPRK, phospho-STAT3Tyr705 was significantly increased in NSCLC cells. Moreover, the phospho-STAT3Tyr705 levels of NSCLC tissues were positively correlated with lymph node metastasis and significantly inversely correlated with the expression of PTPRK (p<0.05). Conclusions. These results suggested that PTPRK functions as a novel tumor suppressor in NSCLC, and its suppressive ability may be involved in STAT3 activation.

Downregulation of gelsolin family proteins counteracts cancer cell invasion in vitro

2007 ◽  
Vol 255 (1) ◽  
pp. 57-70 ◽  
Author(s):  
Anske Van den Abbeele ◽  
Veerle De Corte ◽  
Katrien Van Impe ◽  
Erik Bruyneel ◽  
Ciska Boucherie ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion
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