Chemo-photodynamic combined gene therapy and dual-modal cancer imaging achieved by pH-responsive alginate/chitosan multilayer-modified magnetic mesoporous silica nanocomposites

2017 ◽  
Vol 5 (5) ◽  
pp. 1001-1013 ◽  
Author(s):  
Hong Yang ◽  
Yin Chen ◽  
Zhongyuan Chen ◽  
Yue Geng ◽  
Xiaoxue Xie ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mesoporous Silica ◽  
Cancer Imaging ◽  
Tumor Therapy ◽  
Ct Imaging ◽  
Ph Responsive ◽  
Silica Nanocomposites ◽  
Combined Gene Therapy ◽  
Magnetic Mesoporous Silica

Novel nanocomposites were fabricated as theranostics for MR/CT imaging and tumor therapy in vivo.

Redox-Responsive Nanocarrier Based on Heparin End-Capped Mesoporous Silica Nanoparticles for Targeted Tumor Therapy in Vitro and in Vivo

Langmuir ◽  
2014 ◽  
Vol 30 (26) ◽  
pp. 7867-7877 ◽  
Author(s):  
Liangliang Dai ◽  
Jinghua Li ◽  
Beilu Zhang ◽  
Junjie Liu ◽  
Zhong Luo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Redox Responsive

scholarly journals One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 37433-37440 ◽  
Author(s):  
Huicong Zhang ◽  
Xuandong Wang ◽  
Peiyuan Wang ◽  
Rong Liu ◽  
Xuemei Hou ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
One Pot ◽  
Silica Nanocomposites ◽  
One Pot Synthesis ◽  
Drug Nanocarriers

Polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot approach. They were demonstrated to be good biodegradability, pH-responsive drug release and targeting synergistic chemo-photothermal therapy.

pH-Responsive Magnetic Mesoporous Silica-Based Nanoplatform for Synergistic Photodynamic Therapy/Chemotherapy

2018 ◽  
Vol 10 (17) ◽  
pp. 15001-15011 ◽  
Author(s):  
Xiang-long Tang ◽  
Feng Jing ◽  
Ben-lan Lin ◽  
Sheng Cui ◽  
Ru-tong Yu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Ph Responsive ◽  
Magnetic Mesoporous Silica

Crown ether triad modified core–shell magnetic mesoporous silica nanocarrier for pH-responsive drug delivery and magnetic hyperthermia applications

2017 ◽  
Vol 41 (19) ◽  
pp. 10935-10947 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Crown Ether ◽  
Magnetic Hyperthermia ◽  
Core Shell ◽  
Ph Responsive ◽  
Magnetic Mesoporous Silica

A “host–guest” complexation-based core–shell FeNP@SiOH@CET NP system was fabricated for chemotherapy and magnetic hyperthermia applications.

Improved in vivo tumor therapy via host–guest complexation

2016 ◽  
Vol 4 (15) ◽  
pp. 2691-2696 ◽  
Author(s):  
Yong Yao ◽  
Yang Wang ◽  
Ruibo Zhao ◽  
Li Shao ◽  
Ruikang Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Intracellular Ph ◽  
Tumor Therapy ◽  
Controlled Drug Delivery ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mesoporous Nanoparticles

A decomposable and intracellular pH-responsive drug delivery system by immobilizing a water-soluble pillar[5]arene onto hollow mesoporous nanoparticles through host–guest complexation was successfully prepared and its application in controlled drug delivery in vitro and in vivo was also investigated.

scholarly journals Targeted Protein Liposomes-Mediated AChE Gene Therapy for Effective Liver Cancer Treatment

2020 ◽  
Author(s):  
Kai Wang ◽  
Fusheng Shang ◽  
Dagui Chen ◽  
Jianpeng Jiao ◽  
Tieliu Cao ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Liver Cancer ◽  
Nude Mice ◽  
Transfection Efficiency ◽  
Tumor Therapy ◽  
Viral Gene ◽  
Therapeutic Gene ◽  
Vector Systems

Abstract The development of highly efficient non-viral gene vector systems has very important application value in the field of cancer therapy. The high protein content of proteolipids allows for high biocompatibility, low immunogenicity, and surface modification of proteins to confer more targeted drug/gene function. For the first time, this study selected transferrin, which has hepatocellular carcinoma cell targeting function, with a liposome backbone material to construct transferrin liposome (Tf-PL), and load acetylcholinesterase (AChE) therapeutic gene for in vitro and in vivo functions evaluation. The results showed that the Tf-PL transfection efficiency was higher than that of commercial Lipo 2000, low cytotoxicity and targeted ability to liver cancer SMMC-7721 cells. After tail vein injection, Tf-PL/AChE can effectively target to liver cancer, significantly inhibiting the growth of liver cancer xenografts in nude mice, prolonging the survival time of tumor-bearing nude mice, and also does not cause significant systemic toxicities. Our study provides a strategy for proteolipids targeting the transferrin receptor to carry therapeutic gene therapy for tumors. This method has strong tumor affinity and can provide an effective vector selection for precise tumor therapy.

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