Development of competitive ‘pseudo’-ELISA assay for measurement of cocaine and its metabolites using molecularly imprinted polymer nanoparticles

2017 ◽  
Vol 9 (31) ◽  
pp. 4592-4598 ◽  
Author(s):  
Yadiris Garcia ◽  
Katarzhina Smolinska-Kempisty ◽  
Eduardo Pereira ◽  
Elena Piletska ◽  
Sergey Piletsky

The assay for cocaine based on molecularly imprinted nanoparticles prepared using solid phase approach is presented.

RSC Advances ◽  
2015 ◽  
Vol 5 (12) ◽  
pp. 9154-9166 ◽  
Author(s):  
Sina Farzaneh ◽  
Ebadullah Asadi ◽  
Majid Abdouss ◽  
Azam Barghi-Lish ◽  
Saman Azodi-Deilami ◽  
...  

The aim of this study was to prepare efficient imprinted polymer nanoparticles from an olanzapine template for the controlled release of olanzapine as a therapeutic drug for CNS diseases.


2019 ◽  
Vol 58 (3) ◽  
pp. 274-279
Author(s):  
Mojtaba Soleimani ◽  
Ameneh Porgham Daryasari ◽  
Parisa Joshani

Abstract In this work, the molecularly imprinted polymer nanoparticles (MIP-NPs) for the selective determination of fluvoxamine have been described. The polymer nanoparticles were synthesized by the polymerization of methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, 2,2-azobisisobutyronitrile as an initiator and fluvoxamine as a template molecule. The MIP-NPs were characterized using techniques that included Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). Imprinted fluvoxamine molecules were removed from the polymeric structure using acetonitrile in methanol (2:8; v/v) as the eluting solvent. The linear dynamic range for fluvoxamine was 10–1200 μg L−1. The developed method was successfully applied to the extraction of fluvoxamine in complex biological samples.


The Analyst ◽  
2016 ◽  
Vol 141 (4) ◽  
pp. 1405-1412 ◽  
Author(s):  
C. Cáceres ◽  
F. Canfarotta ◽  
I. Chianella ◽  
E. Pereira ◽  
E. Moczko ◽  
...  

Here we evaluate whether the size of the template used to produce molecularly imprinted nanoparticles can affect their performance in pseudo-ELISAs.


2021 ◽  
Author(s):  
Isma Haq ◽  
Kaseb D.M. Alanazi ◽  
Joanna Czulak ◽  
Sabrina Di Masi ◽  
Elena Piletska ◽  
...  

A sitagliptin voltammetric sensor was fabricated using artificial receptors called electroactive molecularly imprinted polymer nanoparticles (nanoMIP). The nanoMIP tagged with a redox probe (ferrocene) combines both the recognition and reporting...


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