scholarly journals Determination of sitagliptin in human plasma using a smart electrochemical sensor based on electroactive molecularly imprinted nanoparticles

2021 ◽  
Author(s):  
Isma Haq ◽  
Kaseb D.M. Alanazi ◽  
Joanna Czulak ◽  
Sabrina Di Masi ◽  
Elena Piletska ◽  
...  

A sitagliptin voltammetric sensor was fabricated using artificial receptors called electroactive molecularly imprinted polymer nanoparticles (nanoMIP). The nanoMIP tagged with a redox probe (ferrocene) combines both the recognition and reporting...

2016 ◽  
Vol 8 (33) ◽  
pp. 6305-6312 ◽  
Author(s):  
Ali Motaharian ◽  
Mohammad Reza Milani Hosseini

Procedure for fabrication of electrochemical sensor based on carbon paste electrode modified with molecularly imprinted polymer nanoparticles and graphene nanosheets for selective and sensitive determination of chlordiazepoxide (CDP) drug.


2020 ◽  
Vol 6 (1) ◽  
Author(s):  
A. Garcia-Cruz ◽  
O. S. Ahmad ◽  
K. Alanazi ◽  
E. Piletska ◽  
S. A. Piletsky

Abstract The present research describes the design of robust electrochemical sensors based on electro-responsive molecularly imprinted polymer nanoparticles (e-MIPs). The e-MIPs, tagged with a redox probe, combine both recognition and reporting functions. This system replaces enzyme-mediator pairs used in traditional biosensors. The analyte recognition process relies on the generic actuation phenomenon when the polymer conformation of e-MIPs is changing in response to the presence of the template analyte. The analyte concentration is measured using voltammetric methods. In an exemplification of this technology, electrochemical sensors were developed for the determination of concentrations of trypsin, glucose, paracetamol, C4-homoserine lactone, and THC. The present technology allows for the possibility of producing generic, inexpensive, and robust disposable sensors for clinical, environmental, and forensic applications.


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