Engineering high-performance hairpin stacking circuits for logic gate operation and highly sensitive biosensing assay of microRNA

The Analyst ◽  
2017 ◽  
Vol 142 (24) ◽  
pp. 4834-4842 ◽  
Author(s):  
Yueli Xing ◽  
Xinmin Li ◽  
Taixian Yuan ◽  
Wei Cheng ◽  
Dandan Li ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
High Performance ◽  
Logic Gate ◽  
Strand Displacement ◽  
Gate Operation ◽  
Highly Sensitive

Recently, hairpin stacking circuits (HSC) based on toehold-mediated strand displacement have been engineered to detect nucleic acids and proteins.

Redox-induced target-dependent ratiometric fluorescence sensing strategy and logic gate operation for detection of α-glucosidase activity and its inhibitor

2021 ◽  
Author(s):  
Xucan Yuan ◽  
Yi Sun ◽  
Pengfei Zhao ◽  
Longshan Zhao ◽  
Zhili Xiong
Keyword(s):  
Redox Reaction ◽  
Logic Gate ◽  
Sensitive Detection ◽  
Ratiometric Fluorescence ◽  
Fluorescence Sensing ◽  
Gate Operation ◽  
Glucosidase Activity ◽  
Highly Sensitive ◽  
Highly Sensitive Detection ◽  
Ratiometric Fluorescence Sensing

A target-dependent ratiometric fluorescence sensing strategy was designed and fabricated based on redox reaction for highly sensitive detection of α-glucosidase (α-Glu) activity and its inhibitor. In this study, silicon quantum...

An “on–off–on” fluorescent nanoprobe for recognition of Cu2+ and GSH based on nitrogen co-doped carbon quantum dots, and its logic gate operation

2019 ◽  
Vol 11 (20) ◽  
pp. 2650-2657 ◽  
Author(s):  
Yifang Gao ◽  
Huilin Zhang ◽  
Shaomin Shuang ◽  
Hui Han ◽  
Chuan Dong
Keyword(s):  
Quantum Dots ◽  
Carbon Dots ◽  
Logic Gate ◽  
Carbon Quantum Dots ◽  
Gate Operation ◽  
Fluorescent Nanoprobe ◽  
Highly Sensitive ◽  
Doped Carbon Dots ◽  
Co Doped

Novel nitrogen co-doped carbon dots (NCDs) were synthesized as a fluorescent “on–off–on” switch for the highly sensitive and selective sensing of Cu2+ and glutathione (GSH) by a straightforward pyrolysis route.

HIGHLY SENSITIVE METHODS FOR MICRORNA DETECTION USING ISOTHERMAL METHODS FOR NUCLEIC ACIDS AMPLIFICATION

2021 ◽  
Vol 1 (19) ◽  
pp. 244-246
Author(s):  
O.L. Bodulev ◽  
A.M. Soloviev
Keyword(s):  
Nucleic Acids ◽  
Strand Displacement ◽  
Strand Displacement Amplification ◽  
Microrna Detection ◽  
Highly Sensitive ◽  
Catalytic Hairpin Assembly

This work will present the results of the development of two new highly sensitive heterogeneous methods for the determination of miRNA-141 and miRNA-39 using the isothermal circular strand-displacement amplification and the catalytic hairpin assembly methods for analyte amplification.

Fluorescent Nanoparticle Beacon for Logic Gate Operation Regulated by Strand Displacement

2013 ◽  
Vol 5 (12) ◽  
pp. 5392-5396 ◽  
Author(s):  
Jing Yang ◽  
Lingjing Shen ◽  
Jingjing Ma ◽  
H. Inaki Schlaberg ◽  
Shi Liu ◽  
...  
Keyword(s):  
Logic Gate ◽  
Strand Displacement ◽  
Gate Operation ◽  
Fluorescent Nanoparticle

A DNA logic gate based on strand displacement reaction and rolling circle amplification, responding to multiple low-abundance DNA fragment input signals, and its application in detecting miRNAs

2015 ◽  
Vol 51 (32) ◽  
pp. 6980-6983 ◽  
Author(s):  
Yuqi Chen ◽  
Yanyan Song ◽  
Fan Wu ◽  
Wenting Liu ◽  
Boshi Fu ◽  
...  
Keyword(s):  
Logic Gate ◽  
Rolling Circle Amplification ◽  
Displacement Reaction ◽  
Strand Displacement ◽  
Rolling Circle ◽  
Highly Sensitive ◽  
Dna Fragment ◽  
Highly Sensitive Detection ◽  
Amplification Strategy ◽  
Strand Displacement Reaction

A conveniently amplified DNA AND logic gate platform was designed for the highly sensitive detection of low-abundance DNA fragment inputs based on strand displacement reaction and rolling circle amplification strategy.

Water-Soluble Perylene Diimide for Highly Sensitive and Repeatable Metal Ion Detection with Novel Logic Gate Operation

2019 ◽  
Vol 72 (3) ◽  
pp. 206 ◽  
Author(s):  
Wenxia Liu ◽  
Zhiguang Suo ◽  
Yihao Liu ◽  
Lingyan Feng ◽  
Binbin Zhang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Logic Gate ◽  
Water Soluble ◽  
Optical Intensity ◽  
Gate Operation ◽  
Highly Sensitive ◽  
Metal Ions Detection ◽  
Metal Ion Detection ◽  
Relative Change

In this paper, we report a synthesised water soluble perylene derivative, N,N′-di(2-aspartic acid)-perylene-3,4,9,10-tetracarboxylic diimide (PASP), for highly sensitive and repeatable detection of copper (Cu2+) and aluminium ions (Al3+) and novel logic gate operation. In the presence of metal ions, a dramatic decrease in PASP optical intensity was induced based on the strong interaction between terminal carboxy groups and the metal ions. Detection limits of 0.22 and 0.24μM were respectively obtained at physiological pH. The signals could be recovered upon the addition of ethylenediaminetetraacetate (EDTA) and P2O74−, which competed for Cu2+ and Al3+ in the PASP-CuII and PASP-AlIII systems and induced their dissociation as secondary sensors for anions. At least four detection cycles were performed with a high recovery efficiency. Based on these phenomena, a novel three-level logic gate (OR-IMP-OR) was performed for smart signal readout with metal ions (Cu2+ and Al3+) and anions (EDTA and P2O74−) as input signals, and the relative change of optical intensity of PASP as output signal. Furthermore, the prepared PASP molecule also responded sensitively to Cu2+ and Al3+ in 10% diluted serum medium.

An optical DNA logic gate based on strand displacement and magnetic separation, with response to multiple microRNAs in cancer cell lysates

2017 ◽  
Vol 184 (8) ◽  
pp. 2505-2513 ◽  
Author(s):  
Xiaoting Ji ◽  
Haoyuan Lv ◽  
Minghui Ma ◽  
Binglin Lv ◽  
Caifeng Ding
Keyword(s):  
Magnetic Separation ◽  
Cancer Cell ◽  
Logic Gate ◽  
Strand Displacement ◽  
Cell Lysates

scholarly journals Kinetics of DNA Strand Displacement Systems with Locked Nucleic Acids

2017 ◽  
Vol 121 (12) ◽  
pp. 2594-2602 ◽  
Author(s):  
Xiaoping Olson ◽  
Shohei Kotani ◽  
Bernard Yurke ◽  
Elton Graugnard ◽  
William L. Hughes
Keyword(s):  
Nucleic Acids ◽  
Strand Displacement ◽  
Dna Strand Displacement ◽  
Locked Nucleic Acids ◽  
Dna Strand ◽  
Kinetics Of
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