Single-step homogeneous immunoassay for detecting prostate-specific antigen using dual-color light scattering of metal nanoparticles

The Analyst ◽  
2017 ◽  
Vol 142 (18) ◽  
pp. 3484-3491 ◽  
Author(s):  
Stéphanie Vial ◽  
Jérôme Wenger
Keyword(s):  
Light Scattering ◽  
Metal Nanoparticles ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Single Step ◽  
Biomarker Detection ◽  
Protein Biomarker ◽  
Homogeneous Immunoassay ◽  
Dual Color ◽  
Sandwich Type

Conventional sandwich-type immunoassays are widely used for protein biomarker detection, yet their workflows are challenged by the need for multiple incubation steps separated by washing cycles.

Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review

2020 ◽  
Vol 28 ◽  
Author(s):  
Hayati Filik ◽  
Asiye Aslıhan Avan ◽  
Mustafa Özyürek
Keyword(s):  
Prostate Specific Antigen ◽  
Nanostructured Materials ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Electrochemical Immunosensors ◽  
Metal Metal ◽  
Different Types ◽  
Sandwich Type ◽  
Carbon Based Nanomaterials

: The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This surveys recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate-specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.

3D sandwich-type prostate specific antigen (PSA) immunosensor based on rGO–MWCNT–Pd nanocomposite

2015 ◽  
Vol 39 (7) ◽  
pp. 5522-5528 ◽  
Author(s):  
Lihui Tian ◽  
Lei Liu ◽  
Yueyuan Li ◽  
Qin Wei ◽  
Wei Cao
Keyword(s):  
Detection Limit ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Linear Range ◽  
Wide Linear Range ◽  
Low Detection Limit ◽  
Sandwich Type ◽  
Diagnostic Applications

A signal amplifying sandwich-type immunosensor with a wide linear range and a low detection limit is developed with potential clinical and diagnostic applications.

A sensitive electrochemiluminescent immunosensor based on 3D-flower-like MoS2 microspheres and using AuPt nanoparticles for signal amplification

RSC Advances ◽  
2016 ◽  
Vol 6 (28) ◽  
pp. 23411-23419 ◽  
Author(s):  
Xiu Wang ◽  
Lei Shen ◽  
Wenping Deng ◽  
Mei Yan ◽  
Haiyun Liu ◽  
...  
Keyword(s):  
Prostate Specific Antigen ◽  
Signal Amplification ◽  
Specific Antigen ◽  
Three Dimensional ◽  
Antigen Detection ◽  
Sandwich Type

We herein report the synthesis of MoS2 which was three-dimensional flower-like microspheres, and then the prepared GOx–AuPt and MoS2–luminol were applied in a sandwich-type ECL immunosensor for prostate-specific antigen detection.

An Fe3O4/PEDOT:PSS nanocomposite as an advanced electroconductive material for the biosensing of the prostate-specific antigen in unprocessed human plasma samples

2019 ◽  
Vol 11 (44) ◽  
pp. 5661-5672 ◽  
Author(s):  
Mina Shaban ◽  
Mohammad Hasanzadeh ◽  
Elham Solhi
Keyword(s):  
Human Plasma ◽  
Prostate Specific Antigen ◽  
Signal Amplification ◽  
Specific Antigen ◽  
Plasma Samples ◽  
Real Samples ◽  
Human Plasma Samples ◽  
Sandwich Type ◽  
Amplification Strategy

A novel sandwich-type biosensor based on a signal amplification strategy of various nanocomposites was developed to monitor the prostate-specific antigen (PSA) in real samples.

Electrochemical sandwich-type immunosensor for detection of PSA based on trimetallic AgAuPt nanocomposite synthesized using galvanic replacement reaction

2021 ◽  
Author(s):  
Akbar Khanmohammadi ◽  
Abbas Afkhami ◽  
Ali Hajian ◽  
Hosein Khoshsafar ◽  
Hasan Bagheri
Keyword(s):  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Galvanic Replacement ◽  
Electrochemical Immunoassay ◽  
Galvanic Replacement Reaction ◽  
Replacement Reaction ◽  
Metallic Salts ◽  
Sandwich Type

A sandwich-type electrochemical immunoassay was introduced to the determination of prostate-specific antigen (PSA) biomarker. A direct and simple galvanic replacement reaction was performed between the Ag framework and metallic salts...

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