MSAllstrategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra

The Analyst ◽  
2017 ◽  
Vol 142 (22) ◽  
pp. 4279-4288 ◽  
Author(s):  
Lei Yin ◽  
Chong Su ◽  
Tianming Ren ◽  
Xiangjun Meng ◽  
Meiyun Shi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Weight ◽  
Quantitative Analysis ◽  
High Resolution ◽  
Covalent Attachment ◽  
Small Molecular Weight ◽  
Biological Efficacy ◽  
Therapeutic Compounds

Covalent attachment of PEG to therapeutic compounds (PEGylation) is one of the best techniques to improve the biological efficacy of small molecular weight drugs.

scholarly journals Mass spectrometry–based proteomics in cell biology

2010 ◽  
Vol 190 (4) ◽  
pp. 491-500 ◽  
Author(s):  
Tobias C. Walther ◽  
Matthias Mann
Keyword(s):  
Mass Spectrometry ◽  
Quantitative Analysis ◽  
High Resolution ◽  
Sample Preparation ◽  
Cell Biology ◽  
Computational Analysis ◽  
Global Analysis ◽  
Protein Composition ◽  
Broad Community

The global analysis of protein composition, modifications, and dynamics are important goals in cell biology. Mass spectrometry (MS)–based proteomics has matured into an attractive technology for this purpose. Particularly, high resolution MS methods have been extremely successful for quantitative analysis of cellular and organellar proteomes. Rapid advances in all areas of the proteomic workflow, including sample preparation, MS, and computational analysis, should make the technology more easily available to a broad community and turn it into a staple methodology for cell biologists.

Sign in / Sign up

Export Citation Format

Share Document