scholarly journals Biodegradable nitric oxide precursor-loaded micro- and nanoparticles for the treatment of Staphylococcus aureus biofilms

2017 ◽  
Vol 5 (5) ◽  
pp. 1005-1014 ◽  
Author(s):  
Sayeed Hasan ◽  
Nicky Thomas ◽  
Benjamin Thierry ◽  
Clive A. Prestidge
Keyword(s):  
Nitric Oxide ◽  
Staphylococcus Aureus ◽  
Infectious Diseases ◽  
Planktonic Bacteria ◽  
Oxide Precursor

Bacteria in biofilms are more difficult to eradicate than planktonic bacteria and result in treatment challenges for many chronic infectious diseases.

Controlled and Localized Nitric Oxide Precursor Delivery From Chitosan Gels to Staphylococcus aureus Biofilms

2017 ◽  
Vol 106 (12) ◽  
pp. 3556-3563 ◽  
Author(s):  
Sayeed Hasan ◽  
Nicky Thomas ◽  
Benjamin Thierry ◽  
Clive A. Prestidge
Keyword(s):  
Nitric Oxide ◽  
Staphylococcus Aureus ◽  
Oxide Precursor

scholarly journals Nitric Oxide: The Missing Factor in COVID-19 Severity?

2021 ◽  
Vol 10 (1) ◽  
pp. 3
Author(s):  
Alexandros Nikolaidis ◽  
Ron Kramer ◽  
Sergej Ostojic
Keyword(s):  
Nitric Oxide ◽  
Infectious Diseases ◽  
Respiratory Tract ◽  
Patient Outcomes ◽  
Scientific Community ◽  
Medical Attention ◽  
Clinical Patient ◽  
Transmission Rates ◽  
Oxide Precursor ◽  
The World

Coronavirus disease 2019 (COVID-19) is a contagious respiratory and vascular disease that continues to spread among people around the world, mutating into new strains with increased transmission rates, such as the delta variant. The scientific community is struggling to discover the link between negative COVID-19 outcomes in patients with preexisting conditions, as well as identify the cause of the negative clinical patient outcomes (patients who need medical attention, including hospitalization) in what seems like a widespread range of COVID-19 symptoms that manifest atypically to any preexisting respiratory tract infectious diseases known so far. Having successfully developed a nutritional formulation intervention based on nitrate, a nitric oxide precursor, the authors hypothesis is that both the comorbidities associated with negative clinical patient outcomes and symptoms associated with COVID-19 sickness are linked to the depletion of a simple molecule: nitric oxide.

Inhibition of microbial adherence by sphinganine

1992 ◽  
Vol 38 (9) ◽  
pp. 983-985 ◽  
Author(s):  
Debra Jan Bibel ◽  
Raza Aly ◽  
Henry R. Shinefield
Keyword(s):  
Staphylococcus Aureus ◽  
Infectious Diseases ◽  
Therapeutic Agents ◽  
Eukaryotic Cells ◽  
Buccal Cells ◽  
Streptococcus Mitis ◽  
Buccal Epithelial Cells ◽  
Mucosal Cells ◽  
Microbial Adherence ◽  
Complex Sphingolipids

Sphingosines (precursors and degeneration products of complex sphingolipids) are mediators in membrane second-messenger cascades and in a wide variety of functions in eukaryotic cells. Sphingosines are also lethal for gram-positive microorganisms. In addition to its direct effect, sphinganine is here reported to affect the adherence of Streptococcus mitis to buccal epithelial cells and of Staphylococcus aureus to nasal mucosal cells after incubation for 90 min at 37 °C. When the bacteria were pretreated with 8.1, 16.2, 32.5, or (for Strep. mitis) 65 μM sphinganine for 60 min at 37 °C, adherence counts were reduced for Staph. aureus by 27, 37, and 60% and for Strep. mitis by 19, 44, 54, and 73%, respectively (p < 0.001). In contrast, pretreatment of buccal cells with 81.2 μM lipid increased adherence by 14% (p < 0.01), but no change occurred at either 16.2 or 325 μM lipid. These results further demonstrate the double-edged ability of sphingosines to regulate cellular activities and their potential as multifunctional therapeutic agents for infectious diseases. Key words: adherence, sphingosine, Staphylococcus aureus, Streptococcus mitis.

scholarly journals Mouse models for infectious diseases caused by Staphylococcus aureus

2014 ◽  
Vol 410 ◽  
pp. 88-99 ◽  
Author(s):  
Hwan Keun Kim ◽  
Dominique Missiakas ◽  
Olaf Schneewind
Keyword(s):  
Staphylococcus Aureus ◽  
Infectious Diseases ◽  
Mouse Models
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