Photosensitizer-complexed polypyrrole nanoparticles for activatable fluorescence imaging and photodynamic therapy

2016 ◽  
Vol 4 (47) ◽  
pp. 7545-7548 ◽  
Author(s):  
Dongjin Park ◽  
Jisu Kim ◽  
Yongdoo Choi
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Photodynamic Therapy Of Cancer ◽  
Polypyrrole Nanoparticles

Photosensitizer-complexed polypyrrole nanoparticles for real-time fluorescence imaging and photodynamic therapy of cancer.

Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells

ACS Nano ◽  
2012 ◽  
Vol 6 (5) ◽  
pp. 4054-4062 ◽  
Author(s):  
Kai Liu ◽  
Xiaomin Liu ◽  
Qinghui Zeng ◽  
Youlin Zhang ◽  
Langping Tu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Photodynamic Therapy Of Cancer

scholarly journals Measurement of Cyanine Dye Photobleaching in Photosensitizer Cyanine Dye Conjugates Could Help in Optimizing Light Dosimetry for Improved Photodynamic Therapy of Cancer

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1842 ◽  
Author(s):  
Nadine James ◽  
Ravindra Cheruku ◽  
Joseph Missert ◽  
Ulas Sunar ◽  
Ravindra Pandey
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Tumor Response ◽  
Cyanine Dye ◽  
Fluence Rate ◽  
Low Light ◽  
Light Dosimetry ◽  
Light Fluence ◽  
Photodynamic Therapy Of Cancer

Photodynamic therapy (PDT) of cancer is dependent on three primary components: photosensitizer (PS), light and oxygen. Because these components are interdependent and vary during the dynamic process of PDT, assessing PDT efficacy may not be trivial. Therefore, it has become necessary to develop pre-treatment planning, on-line monitoring and dosimetry strategies during PDT, which become more critical for two or more chromophore systems, for example, PS-CD (Photosensitizer-Cyanine dye) conjugates developed in our laboratory for fluorescence-imaging and PDT of cancer. In this study, we observed a significant impact of variable light dosimetry; (i) high light fluence and fluence rate (light dose: 135 J/cm2, fluence rate: 75 mW/cm2) and (ii) low light fluence and fluence rate (128 J/cm2 and 14 mW/cm2 and 128 J/cm2 and 7 mW/cm2) in photobleaching of the individual chromophores of PS-CD conjugates and their long-term tumor response. The fluorescence at the near-infrared (NIR) region of the PS-NIR fluorophore conjugate was assessed intermittently via fluorescence imaging. The loss of fluorescence, photobleaching, caused by singlet oxygen from the PS was mapped continuously during PDT. The tumor responses (BALB/c mice bearing Colon26 tumors) were assessed after PDT by measuring tumor sizes daily. Our results showed distinctive photobleaching kinetics rates between the PS and CD. Interestingly, compared to higher light fluence, the tumors exposed at low light fluence showed reduced photobleaching and enhanced long-term PDT efficacy. The presence of NIR fluorophore in PS-CD conjugates provides an opportunity of fluorescence imaging and monitoring the photobleaching rate of the CD moiety for large and deeply seated tumors and assessing PDT tumor response in real-time.

Water-Soluble Polythiophene for Two-Photon Excitation Fluorescence Imaging and Photodynamic Therapy of Cancer

2017 ◽  
Vol 9 (17) ◽  
pp. 14590-14595 ◽  
Author(s):  
Minhuan Lan ◽  
Shaojing Zhao ◽  
Yusheng Xie ◽  
Junfang Zhao ◽  
Liang Guo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Water Soluble ◽  
Two Photon ◽  
Photon Excitation ◽  
Photodynamic Therapy Of Cancer ◽  
Two Photon Excitation

scholarly journals Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mi Hyeon Cho ◽  
Yan Li ◽  
Pui-Chi Lo ◽  
Hyeri Lee ◽  
Yongdoo Choi
Keyword(s):  
Endothelial Cells ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Oxygen Generation ◽  
Photodynamic Therapy Of Cancer ◽  
Near Infrared Fluorescence Imaging

Abstract In this study, a fucoidan-based theranostic nanogel (CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve activatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy (PDT) to induce the complete death of cancer cells. A CFN-gel has nanomolar affinity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention effect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar affinity for the vascular endothelial growth factor, it also provides a significant anti-tumor effect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high efficacy and specificity.

scholarly journals A Review on (Hydro)Porphyrin-Loaded Polymer Micelles: Interesting and Valuable Platforms for Enhanced Cancer Nanotheranostics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 81
Author(s):  
Bruno Nascimento ◽  
Nelson Pereira ◽  
Artur Valente ◽  
Teresa Pinho e Melo ◽  
Marta Pineiro
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Polymeric Micelles ◽  
Therapeutic Agents ◽  
Imaging Agents ◽  
Full Potential ◽  
Polymer Micelles ◽  
Photodynamic Therapy Of Cancer ◽  
Nir Fluorescence ◽  
Theranostic Agents

Porphyrins are known therapeutic agents for photodynamic therapy of cancer and also imaging agents for NIR fluorescence imaging, MRI, or PET. A combination of interesting features makes tetrapyrrolic macrocycles suitable for use as theranostic agents whose full potential can be achieved using nanocarriers. This review provides an overview on nanotheranostic agents based on polymeric micelles and porphyrins developed so far.

Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy

2021 ◽  
pp. 2002177
Author(s):  
Hongxin Lin ◽  
Zexi Lin ◽  
Konghua Zheng ◽  
Chenlu Wang ◽  
Lisheng Lin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared
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