Covalently Assembled NIR Nanoplatform for Simultaneous Fluorescence Imaging and Photodynamic Therapy of Cancer Cells

ACS Nano ◽  
2012 ◽  
Vol 6 (5) ◽  
pp. 4054-4062 ◽  
Author(s):  
Kai Liu ◽  
Xiaomin Liu ◽  
Qinghui Zeng ◽  
Youlin Zhang ◽  
Langping Tu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Photodynamic Therapy Of Cancer

scholarly journals Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mi Hyeon Cho ◽  
Yan Li ◽  
Pui-Chi Lo ◽  
Hyeri Lee ◽  
Yongdoo Choi
Keyword(s):  
Endothelial Cells ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Oxygen Generation ◽  
Photodynamic Therapy Of Cancer ◽  
Near Infrared Fluorescence Imaging

Abstract In this study, a fucoidan-based theranostic nanogel (CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve activatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy (PDT) to induce the complete death of cancer cells. A CFN-gel has nanomolar affinity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention effect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar affinity for the vascular endothelial growth factor, it also provides a significant anti-tumor effect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high efficacy and specificity.

Multimodal Upconversion Nanoplatform with a Mitochondria-Targeted Property for Improved Photodynamic Therapy of Cancer Cells

2016 ◽  
Vol 55 (8) ◽  
pp. 3872-3880 ◽  
Author(s):  
Xiaoman Zhang ◽  
Fujin Ai ◽  
Tianying Sun ◽  
Feng Wang ◽  
Guangyu Zhu
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer

Selenorhodamine photosensitizers with the Texas-red core for photodynamic therapy of cancer cells

2015 ◽  
Vol 23 (15) ◽  
pp. 4501-4507 ◽  
Author(s):  
Mark W. Kryman ◽  
Kellie S. Davies ◽  
Michelle K. Linder ◽  
Tymish Y. Ohulchanskyy ◽  
Michael R. Detty
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer ◽  
Red Core ◽  
Texas Red

scholarly journals Correction: Separately doped upconversion-C60 nanoplatform for NIR imaging-guided photodynamic therapy of cancer cells

2019 ◽  
Vol 55 (10) ◽  
pp. 1518-1518 ◽  
Author(s):  
Xiaomin Liu ◽  
Min Zheng ◽  
Xianggui Kong ◽  
Youlin Zhang ◽  
Qinghui Zeng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Nir Imaging ◽  
Photodynamic Therapy Of Cancer

Correction for ‘Separately doped upconversion-C60 nanoplatform for NIR imaging-guided photodynamic therapy of cancer cells’ by Xiaomin Liu et al., Chem. Commun., 2013, 49, 3224–3226.

scholarly journals Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

2019 ◽  
Vol 55 (81) ◽  
pp. 12231-12234 ◽  
Author(s):  
Limiao Shi ◽  
Christophe Nguyen ◽  
Morgane Daurat ◽  
Abdelhamid Chiheb Dhieb ◽  
Wajda Smirani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Breast Cancer Cells ◽  
Two Photon ◽  
Theranostic Applications

Three new biocompatible porphyrin-based oxygen photosensitisers were tested in vitro on breast cancer cells via 2P-PDT: one of them, 66 times more active than H2TPP, gave quite promising results for theranostic applications.

Nanoassembly of an amphiphilic cyclodextrin and Zn(ii)-phthalocyanine with the potential for photodynamic therapy of cancer

RSC Advances ◽  
2014 ◽  
Vol 4 (83) ◽  
pp. 43903-43911 ◽  
Author(s):  
Claudia Conte ◽  
Angela Scala ◽  
Gabriel Siracusano ◽  
Nancy Leone ◽  
Salvatore Patanè ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer ◽  
Photodynamic Activity ◽  
Highly Hydrophobic ◽  
Amphiphilic Cyclodextrin

A photosensitising nanoassembly from non-ionic amphiphilic cyclodextrin and highly hydrophobic Zn-pthalocyanine with the capability to sustain the release of photosensitiser and showing photodynamic activity in cancer cells.

Absorption-dependent generation of singlet oxygen from gold bipyramids excited under low power density

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 81897-81904 ◽  
Author(s):  
Junliang Lv ◽  
Xin Zhang ◽  
Nana Li ◽  
Baoju Wang ◽  
Sailing He
Keyword(s):  
Photodynamic Therapy ◽  
Low Power ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Power Density ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Photodynamic Therapy Of Cancer

Gold bipyramid-mediated singlet oxygen generation for photodynamic therapy of cancer cells in the optical biological window.

scholarly journals Extended rhodamine photosensitizers for photodynamic therapy of cancer cells

2016 ◽  
Vol 24 (17) ◽  
pp. 3908-3917 ◽  
Author(s):  
Kellie S. Davies ◽  
Michelle K. Linder ◽  
Mark W. Kryman ◽  
Michael R. Detty
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer

Photosensitizer-complexed polypyrrole nanoparticles for activatable fluorescence imaging and photodynamic therapy

2016 ◽  
Vol 4 (47) ◽  
pp. 7545-7548 ◽  
Author(s):  
Dongjin Park ◽  
Jisu Kim ◽  
Yongdoo Choi
Keyword(s):  
Photodynamic Therapy ◽  
Real Time ◽  
Fluorescence Imaging ◽  
Photodynamic Therapy Of Cancer ◽  
Polypyrrole Nanoparticles

Photosensitizer-complexed polypyrrole nanoparticles for real-time fluorescence imaging and photodynamic therapy of cancer.

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