Aptamer based electrostatic-stimuli responsive surfaces for on-demand binding/unbinding of a specific ligand

2017 ◽  
Vol 5 (20) ◽  
pp. 3675-3685 ◽  
Author(s):  
Xiao Ma ◽  
Agnivo Gosai ◽  
Ganesh Balasubramanian ◽  
Pranav Shrotriya
Keyword(s):  
Stimuli Responsive ◽  
On Demand ◽  
Responsive Surfaces ◽  
Electrical Stimuli ◽  
Specific Ligand

We report an aptamer functionalized stimuli responsive surface that can controllably switch between binding and releasing its specific ligand α-thrombin under application of electrical stimuli.

Carborane Guests for Cucurbit[7]uril Facilitate Strong Binding and on Demand Removal

2020 ◽  
Author(s):  
Anna Kataki-Anastasakou ◽  
Jonathan C. Axtell ◽  
Selena Hernandez ◽  
RafalM. Dziedzic ◽  
Gary J. Balaich ◽  
...  
Keyword(s):  
Free State ◽  
Stimuli Responsive ◽  
Additional Consideration ◽  
Boron Clusters ◽  
High Affinity ◽  
On Demand ◽  
Azide Anion ◽  
Strong Binding

High affinity guest have been reported for the macrocyclic host cucurbit[7]uril (CB[7]), enabling widespread applications, but preventing CB[7] materials from being returned to their guest-free state for reuse. Here we present polyhedral boron clusters (carboranes) as strongly-binding, yet easily removable, guests for CB[7]. Aided by a Pd-catalyzed coupling of an azide anion, we prepared boron-functionalized 9<i>-</i>amino and 9-ammonium modified <i>ortho-</i>carboranes that bind to CB[7] with a <i>K<sub>a</sub></i>=10<sup>10</sup> M<sup>-1</sup>. Upon treatment with base, the <i>ortho</i>-carboranes<i> </i>readily undergo deboronation to yield anionic <i>nido</i>-carborane, a poor guest of CB[7], facilitating recovery of guest-free CB[7]. We showcase the utility of the modified <i>ortho</i>-carborane guest by recycling a CB[7]-functionalized resin. With this report, we introduce stimuli-responsive decomplexation as an additional consideration in the design of high affinity host-guest complexes.

A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents

2017 ◽  
Vol 48 ◽  
pp. 110-119 ◽  
Author(s):  
Hugh S. O’Neill ◽  
Caroline C. Herron ◽  
Conn L. Hastings ◽  
Roel Deckers ◽  
Adolfo Lopez Noriega ◽  
...  
Keyword(s):  
Therapeutic Agents ◽  
Stimuli Responsive ◽  
On Demand

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Stimuli-Responsive Surfaces for Tunable and Reversible Control of Wettability

2015 ◽  
Vol 27 (27) ◽  
pp. 4062-4068 ◽  
Author(s):  
Xu Huang ◽  
Yajuan Sun ◽  
Siowling Soh
Keyword(s):  
Stimuli Responsive ◽  
Responsive Surfaces

scholarly journals Carborane Guests for Cucurbit[7]uril Facilitate Strong Binding and on Demand Removal

2020 ◽  
Author(s):  
Anna Kataki-Anastasakou ◽  
Jonathan C. Axtell ◽  
Selena Hernandez ◽  
RafalM. Dziedzic ◽  
Gary J. Balaich ◽  
...  
Keyword(s):  
Free State ◽  
Stimuli Responsive ◽  
Additional Consideration ◽  
Boron Clusters ◽  
High Affinity ◽  
On Demand ◽  
Azide Anion ◽  
Strong Binding

High affinity guest have been reported for the macrocyclic host cucurbit[7]uril (CB[7]), enabling widespread applications, but preventing CB[7] materials from being returned to their guest-free state for reuse. Here we present polyhedral boron clusters (carboranes) as strongly-binding, yet easily removable, guests for CB[7]. Aided by a Pd-catalyzed coupling of an azide anion, we prepared boron-functionalized 9<i>-</i>amino and 9-ammonium modified <i>ortho-</i>carboranes that bind to CB[7] with a <i>K<sub>a</sub></i>=10<sup>10</sup> M<sup>-1</sup>. Upon treatment with base, the <i>ortho</i>-carboranes<i> </i>readily undergo deboronation to yield anionic <i>nido</i>-carborane, a poor guest of CB[7], facilitating recovery of guest-free CB[7]. We showcase the utility of the modified <i>ortho</i>-carborane guest by recycling a CB[7]-functionalized resin. With this report, we introduce stimuli-responsive decomplexation as an additional consideration in the design of high affinity host-guest complexes.

Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery

2019 ◽  
Vol 296 ◽  
pp. 93-106 ◽  
Author(s):  
Ying Qu ◽  
Bingyang Chu ◽  
Xiawei Wei ◽  
Minyi Lei ◽  
Danrong Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
On Demand

Transparent Conductive Supramolecular Hydrogels with Stimuli‐Responsive Properties for On‐Demand Dissolvable Diabetic Foot Wound Dressings

2020 ◽  
Vol 41 (24) ◽  
pp. 2000441
Author(s):  
Yue Zhao ◽  
Zuhao Li ◽  
Qiuju Li ◽  
Longfei Yang ◽  
Hou Liu ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Wound Dressings ◽  
Stimuli Responsive ◽  
On Demand
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