Transparent Conductive Supramolecular Hydrogels with Stimuli‐Responsive Properties for On‐Demand Dissolvable Diabetic Foot Wound Dressings

2020 ◽  
Vol 41 (24) ◽  
pp. 2000441
Author(s):  
Yue Zhao ◽  
Zuhao Li ◽  
Qiuju Li ◽  
Longfei Yang ◽  
Hou Liu ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Wound Dressings ◽  
Stimuli Responsive ◽  
On Demand

Carborane Guests for Cucurbit[7]uril Facilitate Strong Binding and on Demand Removal

2020 ◽  
Author(s):  
Anna Kataki-Anastasakou ◽  
Jonathan C. Axtell ◽  
Selena Hernandez ◽  
RafalM. Dziedzic ◽  
Gary J. Balaich ◽  
...  
Keyword(s):  
Free State ◽  
Stimuli Responsive ◽  
Additional Consideration ◽  
Boron Clusters ◽  
High Affinity ◽  
On Demand ◽  
Azide Anion ◽  
Strong Binding

High affinity guest have been reported for the macrocyclic host cucurbit[7]uril (CB[7]), enabling widespread applications, but preventing CB[7] materials from being returned to their guest-free state for reuse. Here we present polyhedral boron clusters (carboranes) as strongly-binding, yet easily removable, guests for CB[7]. Aided by a Pd-catalyzed coupling of an azide anion, we prepared boron-functionalized 9<i>-</i>amino and 9-ammonium modified <i>ortho-</i>carboranes that bind to CB[7] with a <i>K<sub>a</sub></i>=10<sup>10</sup> M<sup>-1</sup>. Upon treatment with base, the <i>ortho</i>-carboranes<i> </i>readily undergo deboronation to yield anionic <i>nido</i>-carborane, a poor guest of CB[7], facilitating recovery of guest-free CB[7]. We showcase the utility of the modified <i>ortho</i>-carborane guest by recycling a CB[7]-functionalized resin. With this report, we introduce stimuli-responsive decomplexation as an additional consideration in the design of high affinity host-guest complexes.

A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents

2017 ◽  
Vol 48 ◽  
pp. 110-119 ◽  
Author(s):  
Hugh S. O’Neill ◽  
Caroline C. Herron ◽  
Conn L. Hastings ◽  
Roel Deckers ◽  
Adolfo Lopez Noriega ◽  
...  
Keyword(s):  
Therapeutic Agents ◽  
Stimuli Responsive ◽  
On Demand

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

Innovation and new technologies in hydrogel wound dressings for treating diabetic foot ulcers: a twenty-year review

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S184
Author(s):  
J.E. Ävila-Quiroga ◽  
V. Pinzön-Mora ◽  
V.A. Solarte-David ◽  
S.M. Becerra-Bayona ◽  
M.L. Luna-Gonzalez
Keyword(s):  
Diabetic Foot ◽  
New Technologies ◽  
Wound Dressings ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers

scholarly journals Carborane Guests for Cucurbit[7]uril Facilitate Strong Binding and on Demand Removal

2020 ◽  
Author(s):  
Anna Kataki-Anastasakou ◽  
Jonathan C. Axtell ◽  
Selena Hernandez ◽  
RafalM. Dziedzic ◽  
Gary J. Balaich ◽  
...  
Keyword(s):  
Free State ◽  
Stimuli Responsive ◽  
Additional Consideration ◽  
Boron Clusters ◽  
High Affinity ◽  
On Demand ◽  
Azide Anion ◽  
Strong Binding

High affinity guest have been reported for the macrocyclic host cucurbit[7]uril (CB[7]), enabling widespread applications, but preventing CB[7] materials from being returned to their guest-free state for reuse. Here we present polyhedral boron clusters (carboranes) as strongly-binding, yet easily removable, guests for CB[7]. Aided by a Pd-catalyzed coupling of an azide anion, we prepared boron-functionalized 9<i>-</i>amino and 9-ammonium modified <i>ortho-</i>carboranes that bind to CB[7] with a <i>K<sub>a</sub></i>=10<sup>10</sup> M<sup>-1</sup>. Upon treatment with base, the <i>ortho</i>-carboranes<i> </i>readily undergo deboronation to yield anionic <i>nido</i>-carborane, a poor guest of CB[7], facilitating recovery of guest-free CB[7]. We showcase the utility of the modified <i>ortho</i>-carborane guest by recycling a CB[7]-functionalized resin. With this report, we introduce stimuli-responsive decomplexation as an additional consideration in the design of high affinity host-guest complexes.

scholarly journals The importance of oxygen release in diabetic foot ulcer wounds

2019 ◽  
Vol 1 (1) ◽  
pp. 002-011
Keyword(s):  
Diabetic Foot ◽  
Therapeutic Process ◽  
Healing Process ◽  
Foot Ulcer ◽  
Essential Element ◽  
Diabetic Foot Ulcer ◽  
Wound Dressings ◽  
Self Healing ◽  
Healthy Human ◽  
Affected Tissue

Oxygen is the essential element required for proper physiological function of cells, tissues and organs within healthy human body. Thanks to its intricate structure, the skin provides a multiprotective barrier against traumatic and non-traumatic injuries, but also a complex and successful self-healing process of the affected tissue. In the particular case of chronic skin wounds, such as diabetic foot ulcer wounds, there is an immediate demand to develop alternative procedures that prevent infection, speed up healing and eliminate any disrupting factor that may interfere with the therapeutic process. Given the importance of oxygen during wound healing cascade, impressive attention was oriented towards the fabrication of oxygen-releasing wound dressings.

Redox/pH dual-stimuli responsive camptothecin prodrug nanogels for “on-demand” drug delivery

2019 ◽  
Vol 296 ◽  
pp. 93-106 ◽  
Author(s):  
Ying Qu ◽  
Bingyang Chu ◽  
Xiawei Wei ◽  
Minyi Lei ◽  
Danrong Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stimuli Responsive ◽  
On Demand

Bacterial Enzyme Responsive Polymersomes: A Closer Look at the Degradation Mechanism of PEG-block-PLA Vesicles

2014 ◽  
Vol 67 (4) ◽  
pp. 578 ◽  
Author(s):  
Katrin-Stephanie Tücking ◽  
Stephan Handschuh-Wang ◽  
Holger Schönherr
Keyword(s):  
Lactic Acid ◽  
Pathogenic Bacteria ◽  
Degradation Mechanism ◽  
Wound Dressings ◽  
Proteinase K ◽  
Poly Lactic Acid ◽  
Fluorescence Lifetime Imaging ◽  
Stimuli Responsive ◽  
Bacterial Enzyme ◽  
Poly Ethylene

Stimuli-responsive polymersomes that are selectively cleaved by enzymes of pathogenic bacteria are herein reported. The local disruption of the polyester wall in poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) polymersomes filled with reporter dyes owing to enzymatic degradation by proteinase K was monitored by fluorescence lifetime imaging microscopy. Capsule opening occurred on timescales of minutes to hours, leading to the release of the dye, followed by a slow capsule disintegration, and finally cleavage into monomeric lactic acid over several weeks. These nanocontainers represent a promising element in novel theranostic systems for potential application in advanced wound dressings.

A Prospective Randomized Evaluation of Negative-pressure Wound Dressings for Diabetic Foot Wounds

2003 ◽  
Vol 17 (6) ◽  
pp. 645-649 ◽  
Author(s):  
Mark T. Eginton ◽  
Kellie R. Brown ◽  
Gary R. Seabrook ◽  
Jonathan B. Towne ◽  
Robert A. Cambria
Keyword(s):  
Negative Pressure ◽  
Diabetic Foot ◽  
Wound Dressings ◽  
Randomized Evaluation
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