Size changeable nanosystems for precise drug controlled release and efficient overcoming of cancer multidrug resistance

2017 ◽  
Vol 5 (5) ◽  
pp. 944-952 ◽  
Author(s):  
Xueyang Fang ◽  
Wenting Jiang ◽  
Yanyu Huang ◽  
Fang Yang ◽  
Tianfeng Chen
Keyword(s):  
Multidrug Resistance ◽  
Controlled Release ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Rational Design ◽  
Drug Controlled Release

Herein we demonstrate the rational design of a size changeable nanosystem for precise drug controlled release and efficient overcoming of cancer multidrug resistance in cancer cells by enhancing the cellular uptake and inhibiting the expression of ABC family proteins.

Enhanced cellular uptake and intracellular drug controlled release of VESylated gemcitabine prodrug nanocapsules

2015 ◽  
Vol 128 ◽  
pp. 357-362 ◽  
Author(s):  
Yanfen Fang ◽  
Fang Du ◽  
Yanyun Xu ◽  
Haijing Meng ◽  
Jin Huang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cellular Uptake ◽  
Drug Controlled Release

Chalcone derivatives and their activities against drug-resistant cancers: An overview

2020 ◽  
Vol 20 ◽  
Author(s):  
Jiaqi Xiao ◽  
Meixiang Gao ◽  
Qiang Diao ◽  
Feng Gao
Keyword(s):  
Drug Resistance ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Rational Design ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Chalcone Derivatives ◽  
Potential Activity ◽  
Defensive Mechanisms

: Drug resistance including multidrug resistance resulting from different defensive mechanisms in cancer cells is the leading cause of the failure about the cancer therapy, making it an urgent need to develop more effective anticancer agents. Chalcones, widely distributed in nature, could act on diverse enzymes and receptors in cancer cells. Accordingly, chalcone derivatives possess potential activity against various cancers including drug-resistant even multidrug-resistant cancer. This review outlines the recent development of chalcone derivatives with potential activity against drug-resistant cancers covering articles published between 2010 and 2020, so as to facilitate further rational design of more effective candidate.

Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells

2015 ◽  
Vol 11 (4) ◽  
pp. 947-958 ◽  
Author(s):  
Ting Liu ◽  
Lilan Zeng ◽  
Wenting Jiang ◽  
Yuanting Fu ◽  
Wenjie Zheng ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Rational Design ◽  
Selenium Nanoparticles

Cathepsin B-sensitive cholesteryl hemisuccinate–gemcitabine prodrug nanoparticles: enhanced cellular uptake and intracellular drug controlled release

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6985-6992 ◽  
Author(s):  
Yanyun Xu ◽  
Jianqi Geng ◽  
Ping An ◽  
Yan Xu ◽  
Jin Huang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cellular Uptake ◽  
Cathepsin B ◽  
Drug Controlled Release ◽  
Cholesteryl Hemisuccinate

Cholesteryl hemisuccinate–gemcitabine prodrug: enhanced cellular uptake and intracellular drug controlled release.

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

Sign in / Sign up

Export Citation Format

Share Document