scholarly journals (Intra)Cellular Stability of Inorganic Nanoparticles: Effects on Cytotoxicity, Particle Functionality, and Biomedical Applications

2015 ◽  
Vol 115 (5) ◽  
pp. 2109-2135 ◽  
Author(s):  
Stefaan J. Soenen ◽  
Wolfgang J. Parak ◽  
Joanna Rejman ◽  
Bella Manshian
Keyword(s):  
Biomedical Applications ◽  
Inorganic Nanoparticles

Functionalised Inorganic Nanoparticles for Biomedical Applications

Nanoscience ◽  
2009 ◽  
pp. 129-170 ◽  
Author(s):  
E. Duguet ◽  
M. Treguer-Delapierre ◽  
M.-H. Delville
Keyword(s):  
Biomedical Applications ◽  
Inorganic Nanoparticles

scholarly journals Review of Therapeutic Applications of Radiolabeled Functional Nanomaterials

2019 ◽  
Vol 20 (9) ◽  
pp. 2323 ◽  
Author(s):  
Jongho Jeon
Keyword(s):  
Cancer Therapy ◽  
Anticancer Agents ◽  
Biomedical Applications ◽  
Recent Progress ◽  
Medical Science ◽  
Inorganic Nanoparticles ◽  
Original Material ◽  
Functional Nanomaterials ◽  
Therapeutic Applications ◽  
Physical And Chemical

In the last two decades, various nanomaterials have attracted increasing attention in medical science owing to their unique physical and chemical characteristics. Incorporating radionuclides into conventionally used nanomaterials can confer useful additional properties compared to the original material. Therefore, various radionuclides have been used to synthesize functional nanomaterials for biomedical applications. In particular, several α- or β-emitter-labeled organic and inorganic nanoparticles have been extensively investigated for efficient and targeted cancer treatment. This article reviews recent progress in cancer therapy using radiolabeled nanomaterials including inorganic, polymeric, and carbon-based materials and liposomes. We first provide an overview of radiolabeling methods for preparing anticancer agents that have been investigated recently in preclinical studies. Next, we discuss the therapeutic applications and effectiveness of α- or β-emitter-incorporated nanomaterials in animal models and the emerging possibilities of these nanomaterials in cancer therapy.

Inorganic Nanoparticles for Biomedical Applications

2021 ◽  
pp. 49-72
Author(s):  
Paula M. P. Lins ◽  
Laís Ribovski ◽  
Isabella Sampaio ◽  
Olavo A. Santos ◽  
Valtencir Zucolotto ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Inorganic Nanoparticles

Polymer encapsulation of inorganic nanoparticles for biomedical applications

2013 ◽  
Vol 458 (1) ◽  
pp. 230-241 ◽  
Author(s):  
Rachid Ladj ◽  
Ahmad Bitar ◽  
Mohamed M. Eissa ◽  
Hatem Fessi ◽  
Yannick Mugnier ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Inorganic Nanoparticles ◽  
Polymer Encapsulation

Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications

2017 ◽  
Vol 5 (3) ◽  
pp. 401-417 ◽  
Author(s):  
Weitao Yang ◽  
Weisheng Guo ◽  
Jin Chang ◽  
Bingbo Zhang
Keyword(s):  
Metal Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Nanoparticles ◽  
Biomimetic Synthesis ◽  
Biomimetic Mineralization ◽  
Promising Strategy

Currently, protein/peptide-based biomimetic mineralization has been demonstrated to be an efficient and promising strategy for synthesis of inorganic/metal nanoparticles (NPs) for bioapplications.

scholarly journals Genome-wide DNA methylome and transcriptome changes induced by inorganic nanoparticles in human kidney cells after chronic exposure

2022 ◽  
Author(s):  
Andrea Soltysova ◽  
Patricia Begerova ◽  
Kristina Jakic ◽  
Katarina Kozics ◽  
Monika Sramkova ◽  
...  
Keyword(s):  
Chronic Exposure ◽  
Biomedical Applications ◽  
Human Kidney ◽  
Inorganic Nanoparticles ◽  
Integrated Analysis ◽  
Adverse Health Effects ◽  
Chronic Effects ◽  
Genome Wide ◽  
Detailed Evaluation ◽  
Th 1

AbstractThe unique physicochemical properties make inorganic nanoparticles (INPs) an exciting tool in diagnosis and disease management. However, as INPs are relatively difficult to fully degrade and excrete, their unintended accumulation in the tissue might result in adverse health effects. Herein, we provide a methylome–transcriptome framework for chronic effects of INPs, commonly used in biomedical applications, in human kidney TH-1 cells. Renal clearance is one of the most important routes of nanoparticle excretion; therefore, a detailed evaluation of nanoparticle-mediated nephrotoxicity is an important task. Integrated analysis of methylome and transcriptome changes induced by INPs (PEG-AuNPs, Fe3O4NPs, SiO2NPs, and TiO2NPs) revealed significantly deregulated genes with functional classification in immune response, DNA damage, and cancer-related pathways. Although most deregulated genes were unique to individual INPs, a relatively high proportion of them encoded the transcription factors. Interestingly, FOS hypermethylation inversely correlating with gene expression was associated with all INPs exposures. Our study emphasizes the need for a more comprehensive investigation of INPs’ biological safety, especially after chronic exposure. Graphical abstract

Iron oxide nanoparticles conjugated with organic optical probes for in vivo diagnostic and therapeutic applications

Nanomedicine ◽  
2021 ◽  
Author(s):  
Shalini Sharma ◽  
Nisha Lamichhane ◽  
Parul ◽  
Tapas Sen ◽  
Indrajit Roy
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Optical Probe ◽  
Inorganic Nanoparticles ◽  
Oxide Nanoparticles ◽  
Optical Probes ◽  
Therapeutic Applications

The role and scope of functional inorganic nanoparticles in biomedical research is well established. Among these, iron oxide nanoparticles (IONPs) have gained maximum attention as they can provide targeting, imaging and therapeutic capabilities. Furthermore, incorporation of organic optical probes with IONPs can significantly enhance the scope and viability of their biomedical applications. Combination of two or more such applications renders multimodality in nanoparticles, which can be exploited to obtain synergistic benefits in disease detection and therapy viz theranostics, which is a key trait of nanoparticles for advanced biomedical applications. This review focuses on the use of IONPs conjugated with organic optical probe/s for multimodal diagnostic and therapeutic applications in vivo.

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