Irreversible destruction of amyloid fibril plaques by conjugated polymer based fluorogenic nanogrenades

2016 ◽  
Vol 4 (26) ◽  
pp. 4502-4506 ◽  
Author(s):  
Wei-Tao Dou ◽  
Ying Lv ◽  
Chunyan Tan ◽  
Guo-Rong Chen ◽  
Xiao-Peng He
Keyword(s):  
Conjugated Polymers ◽  
White Light ◽  
Conjugated Polymer ◽  
Amyloid Fibril ◽  
Fluorescent Dyes ◽  
Amyloid Β ◽  
Supramolecular Assembly ◽  
Light Irradiation

Supramolecular assembly between conjugated polymers and fluorescent dyes produces a unique class of fluorogenic “nanogrenades” with the ability to image as well as irreversibly destruct amyloid β fibril plaques by simple white-light irradiation.

Inhibition and disaggregation of amyloid β protein fibrils through conjugated polymer–core thermoresponsive micelles

2020 ◽  
Vol 8 (44) ◽  
pp. 10126-10135
Author(s):  
Hao Geng ◽  
Hongbo Yuan ◽  
Liang Qiu ◽  
Dong Gao ◽  
Yongqiang Cheng ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
White Light ◽  
Conjugated Polymer ◽  
Amyloid Β ◽  
Reactive Oxygen ◽  
Light Irradiation ◽  
Amyloid Β Protein ◽  
Oxygen Species ◽  
Β Protein ◽  
Protein Fibrils

The micelles (CPMs) have a thermoresponsive surface and reactive oxygen species (ROS) generating core. At 37 °C, CPMs captured Aβ aggregates to inhibit and disaggregate aggregates under white-light irradiation, reducing Aβ-induced cytotoxicity.

Synthesis of fluorescent conjugated polymer nanoparticles and their immobilization on a substrate for white light emission

2018 ◽  
Vol 9 (48) ◽  
pp. 5671-5679 ◽  
Author(s):  
Choongho Kim ◽  
Young Jin Gwon ◽  
Jongho Kim ◽  
Taek Seung Lee
Keyword(s):  
Conjugated Polymers ◽  
White Light ◽  
Conjugated Polymer ◽  
Light Emission ◽  
Coupling Reaction ◽  
Suzuki Coupling ◽  
Polymer Nanoparticles ◽  
Red Emission ◽  
Suzuki Coupling Reaction ◽  
Conjugated Polymer Nanoparticles

Fluorescent conjugated polymers (CPs) for blue, green, and red emission were polymerized via the Suzuki coupling reaction.

scholarly journals An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Devkee M. Vadukul ◽  
Céline Vrancx ◽  
Pierre Burguet ◽  
Sabrina Contino ◽  
Nuria Suelves ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Self Assembly ◽  
Critical Nucleus ◽  
Amyloid Fibril ◽  
Amyloid Β ◽  
Amyloid Plaques ◽  
The Self ◽  
Aβ Peptide ◽  
Amyloid Fibril Formation ◽  
Secretase Activity

AbstractA key hallmark of Alzheimer’s disease is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein, the first step of which gives rise to a C-terminal Fragment (C99). Cleavage of C99 by γ-secretase activity releases Aβ of several lengths and the Aβ42 isoform in particular has been identified as being neurotoxic. The misfolding of Aβ leads to subsequent amyloid fibril formation by nucleated polymerisation. This requires an initial and critical nucleus for self-assembly. Here, we identify and characterise the composition and self-assembly properties of cell-derived hexameric Aβ42 and show its assembly enhancing properties which are dependent on the Aβ monomer availability. Identification of nucleating assemblies that contribute to self-assembly in this way may serve as therapeutic targets to prevent the formation of toxic oligomers.

Strategies and concepts in n-doped conjugated polymer thermoelectrics

2021 ◽  
Vol 9 (9) ◽  
pp. 5149-5163
Author(s):  
Teck Lip Dexter Tam ◽  
Jianwei Xu
Keyword(s):  
Conjugated Polymers ◽  
Conjugated Polymer ◽  
Chemical Structure ◽  
Structure Engineering

In this review, we discuss strategies & concepts in chemical structure engineering for n-type conjugated polymers & n-dopants that have brought about huge improvements in the performance of n-doped conjugated polymer thermoelectrics in recent years.

scholarly journals Supramolecular assembly of conjugated polymers under vibrational strong coupling

2021 ◽  
Author(s):  
Kripa Joseph ◽  
Soh Kushida ◽  
Emanuel Smarsly ◽  
Dris Ihiawakrim ◽  
Anoop Thomas ◽  
...  
Keyword(s):  
Conjugated Polymers ◽  
Strong Coupling ◽  
Supramolecular Assembly

scholarly journals Synthesis and characterization of an electron-deficient conjugated polymer based on pyridine-flanked diketopyrrolopyrrole

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12995-13003
Author(s):  
Jialin Yang ◽  
Li Yang ◽  
Qianqian Chen ◽  
Keke Guo ◽  
Ji-Min Han
Keyword(s):  
Conjugated Polymers ◽  
Electrochemical Properties ◽  
Conjugated Polymer ◽  
Synthesis And Characterization

We report a pyridine-flanked diketopyrrolopyrrole monomer and all-acceptor conjugated polymers synthesized therefrom. Photophysical, thermal and electrochemical properties of the polymers have been determined.

Carbon Nanotube-Induced Planarization of Conjugated Polymers in Solution

2004 ◽  
Vol 858 ◽  
Author(s):  
Jian Chen ◽  
Rajagopal Ramasubramaniam ◽  
Haiying Liu
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Conjugated Polymers ◽  
Spectroscopic Study ◽  
Surface Quality ◽  
Hybrid Materials ◽  
Conjugated Polymer ◽  
Visible Absorption ◽  
The Impact ◽  
Conformational Interaction

ABSTRACTThe understanding of the conformational interaction between conjugated polymers and carbon nanotubes in solution is essential to develop the applications of carbon nanotubes, particularly conjugated polymer-carbon nanotube hybrid materials. The visible absorption spectroscopic study shows that curved carbon nanotube surfaces can induce the planarization of individual conjugated polymers such as poly(p-phenyleneethynylene)s and poly(3-alkylthiophene)s in solution. The impact of nanotube surface quality on the interaction between carbon nanotubes and conjugated polymers is investigated.

scholarly journals Enhanced visible light response of a WO3 photoelectrode with an immobilized fibrous gold nanoparticle assembly using an amyloid-β peptide

RSC Advances ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 1089-1092 ◽  
Author(s):  
Akira Onoda ◽  
Hirofumi Harada ◽  
Taro Uematsu ◽  
Susumu Kuwabata ◽  
Ryo Yamanaka ◽  
...  
Keyword(s):  
Visible Light ◽  
Gold Nanoparticle ◽  
Visible Light Irradiation ◽  
Amyloid Β ◽  
Light Response ◽  
Light Irradiation ◽  
Amyloid Β Peptide ◽  
Aβ Peptide ◽  
Photocurrent Generation ◽  
Visible Light Response

A WO3 photoelectrode immobilizing a fibrous gold nanoparticle (AuNP) assembly using an amyloid-β (Aβ) peptide exhibits enhanced photocurrent generation upon visible light irradiation.

scholarly journals Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor

2016 ◽  
Vol 7 (8) ◽  
pp. 5287-5293 ◽  
Author(s):  
Bingyuan Guo ◽  
Zhiyi Yao ◽  
Lei Liu ◽  
Hai-Chen Wu
Keyword(s):  
Conjugated Polymers ◽  
Conjugated Polymer

Nanopores are effective and powerful tools for the analysis of conformational and aggregational states of conjugated polymers in solution.

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