Cu2-xSe Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping

2013 ◽  
Vol 2 (7) ◽  
pp. 952-957 ◽  
Author(s):  
Xin Liu ◽  
Wing-Cheung Law ◽  
Mansik Jeon ◽  
Xianliang Wang ◽  
Maixian Liu ◽  
...  
Keyword(s):  
Surface Plasmon Resonance ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Contrast Agents ◽  
Localized Surface Plasmon Resonance ◽  
Photoacoustic Imaging ◽  
Sentinel Lymph Node Mapping ◽  
Localized Surface Plasmon ◽  
Lymph Node Mapping

Facile scalable synthesis of highly monodisperse small silica nanoparticles using alkaline buffer solution and their application for efficient sentinel lymph node mapping

2017 ◽  
Vol 5 (3) ◽  
pp. 586-594 ◽  
Author(s):  
Bo Quan ◽  
Chaedong Lee ◽  
Jung Sun Yoo ◽  
Yuanzhe Piao
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Mapping ◽  
Buffer Solution ◽  
Diagnostic Efficacy ◽  
Lymph Node Mapping ◽  
Cancer Nanomedicine ◽  
Scalable Synthesis ◽  
Alkaline Buffer Solution

Cancer nanomedicine involving nanotechnology-based drugs and in vivo imaging agents is an active field of nanoscience that provides new ways of enhancing therapeutic and diagnostic efficacy.

scholarly journals Organic Alternatives to Quantum Dots for Intraoperative Near-Infrared Fluorescent Sentinel Lymph Node Mapping

2005 ◽  
Vol 4 (3) ◽  
pp. 153535002005051 ◽  
Author(s):  
Shunsuke Ohnishi ◽  
Stephen J. Lomnes ◽  
Rita G. Laurence ◽  
Andrew Gogbashian ◽  
Giuliano Mariani ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Contrast Agents ◽  
Clinical Studies ◽  
Near Infrared ◽  
Sentinel Lymph Node Mapping ◽  
Lymph Node Mapping ◽  
Advantages And Disadvantages

Intraoperative near-infrared (NIR) fluorescence imaging provides the surgeon with real-time image guidance during cancer and other surgeries. We have previously reported the use of NIR fluorescent quantum dots (QDs) for sentinel lymph node (SLN) mapping. However, because of concerns over potential toxicity, organic alternatives to QDs will be required for initial clinical studies. We describe a family of 800 nm organic heptamethine indocyanine-based contrast agents for SLN mapping spanning a spectrum from 775 Da small molecules to 7 MDa nanocolloids. We provide a detailed characterization of the optical and physical properties of these contrast agents and discuss the advantages and disadvantages of each. We present robust methods for the covalent conjugation, purification, and characterization of proteins with tetra-sulfonated heptamethine indocyanines, including mass spectroscopic site mapping of highly substituted molecules. One contrast agent, NIR fluorescent human serum albumin (HSA800), emerged as the molecule with the best overall performance with respect to entry to lymphatics, flow to the SLN, retention in the SLN, fluorescence yield and reproducibility. This preclinical study, performed on large animals approaching the size of humans, should serve as a foundation for future clinical studies.

In Vivo Targeted Cancer Imaging, Sentinel Lymph Node Mapping and Multi-Channel Imaging with Biocompatible Silicon Nanocrystals

ACS Nano ◽  
2010 ◽  
Vol 5 (1) ◽  
pp. 413-423 ◽  
Author(s):  
Folarin Erogbogbo ◽  
Ken-Tye Yong ◽  
Indrajit Roy ◽  
Rui Hu ◽  
Wing-Cheung Law ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Silicon Nanocrystals ◽  
Cancer Imaging ◽  
Sentinel Lymph Node Mapping ◽  
Lymph Node Mapping ◽  
Multi Channel Imaging

Comparison of Ex Vivo and In Vivo Injection of Blue Dye in Sentinel Lymph Node Mapping for Colorectal Cancer

2009 ◽  
Vol 33 (3) ◽  
pp. 539-546 ◽  
Author(s):  
Jun Seok Park ◽  
In Taik Chang ◽  
Sung Jun Park ◽  
Beom Gyu Kim ◽  
Yoo Shin Choi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Ex Vivo ◽  
Sentinel Lymph Node Mapping ◽  
Blue Dye ◽  
Lymph Node Mapping
Sign in / Sign up

Export Citation Format

Share Document