scholarly journals Biodegradable fiducial markers for X-ray imaging – soft tissue integration and biocompatibility

2016 ◽  
Vol 4 (34) ◽  
pp. 5700-5712 ◽  
Author(s):  
Żaneta Górecka ◽  
Juliane Teichmann ◽  
Mirko Nitschke ◽  
Adrian Chlanda ◽  
Emilia Choińska ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Medical Imaging ◽  
Promising Material ◽  
Fiducial Markers ◽  
X Ray ◽  
Tissue Integration ◽  
X Ray Imaging ◽  
Material Systems

This study aims at investigation of material for innovative fiducial markers for soft tissue in X-ray based medical imaging. NH3 plasma modified P[LAcoCL] combined with BaSO4 and hydroxyapatite as radio-opaque fillers appears to be a promising material systems for this application.

scholarly journals Visualization Ability of Phase-Contrast Synchrotron-Based X-Ray Imaging Using an X-Ray Interferometer in Soft Tissue Tumors

2021 ◽  
Vol 20 ◽  
pp. 153303382110101
Author(s):  
Thet-Thet Lwin ◽  
Akio Yoneyama ◽  
Hiroko Maruyama ◽  
Tohoru Takeda
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Spatial Resolution ◽  
Phase Contrast ◽  
Soft Tissue Tumors ◽  
X Ray ◽  
3 Dimensional ◽  
Computed Tomography Images ◽  
X Ray Imaging ◽  
X Ray Computed

Phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer provides high sensitivity and high spatial resolution, and it has the ability to depict the fine morphological structures of biological soft tissues, including tumors. In this study, we quantitatively compared phase-contrast synchrotron-based X-ray computed tomography images and images of histopathological hematoxylin-eosin-stained sections of spontaneously occurring rat testicular tumors that contained different types of cells. The absolute densities measured on the phase-contrast synchrotron-based X-ray computed tomography images correlated well with the densities of the nuclear chromatin in the histological images, thereby demonstrating the ability of phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer to reliably identify the characteristics of cancer cells within solid soft tissue tumors. In addition, 3-dimensional synchrotron-based phase-contrast X-ray computed tomography enables screening for different structures within tumors, such as solid, cystic, and fibrous tissues, and blood clots, from any direction and with a spatial resolution down to 26 μm. Thus, phase-contrast synchrotron-based X-ray imaging using an X-ray interferometer shows potential for being useful in preclinical cancer research by providing the ability to depict the characteristics of tumor cells and by offering 3-dimensional information capabilities.

scholarly journals EP-2385: Initial experience of ExacTrac X-Ray imaging for prostate patients with implanted fiducial markers

2018 ◽  
Vol 127 ◽  
pp. S1248
Author(s):  
K. Crowther ◽  
A. O'Neill ◽  
C. Agnew ◽  
D. McKay ◽  
J. Smith ◽  
...  
Keyword(s):  
Fiducial Markers ◽  
Initial Experience ◽  
X Ray ◽  
X Ray Imaging

Enhanced renal image contrast by ethanol fixation in phase-contrast X-ray computed tomography

2014 ◽  
Vol 21 (4) ◽  
pp. 795-800 ◽  
Author(s):  
Ryota Shirai ◽  
Takuya Kunii ◽  
Akio Yoneyama ◽  
Takahito Ooizumi ◽  
Hiroko Maruyama ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Phase Contrast ◽  
Image Contrast ◽  
Fixation Technique ◽  
Outer Medulla ◽  
X Ray ◽  
X Ray Imaging ◽  
Fixation Techniques ◽  
Outer Stripe ◽  
Fine Structures

Phase-contrast X-ray imaging using a crystal X-ray interferometer can depict the fine structures of biological objects without the use of a contrast agent. To obtain higher image contrast, fixation techniques have been examined with 100% ethanol and the commonly used 10% formalin, since ethanol causes increased density differences against background due to its physical properties and greater dehydration of soft tissue. Histological comparison was also performed. A phase-contrast X-ray system was used, fitted with a two-crystal X-ray interferometer at 35 keV X-ray energy. Fine structures, including cortex, tubules in the medulla, and the vessels of ethanol-fixed kidney could be visualized more clearly than that of formalin-fixed tissues. In the optical microscopic images, shrinkage of soft tissue and decreased luminal space were observed in ethanol-fixed kidney; and this change was significantly shown in the cortex and outer stripe of the outer medulla. The ethanol fixation technique enhances image contrast by approximately 2.7–3.2 times in the cortex and the outer stripe of the outer medulla; the effect of shrinkage and the physical effect of ethanol cause an increment of approximately 78% and 22%, respectively. Thus, the ethanol-fixation technique enables the image contrast to be enhanced in phase-contrast X-ray imaging.

scholarly journals Ultra-efficient, widely tunable gold nanoparticle-based fiducial markers for X-ray imaging

Nanoscale ◽  
2016 ◽  
Vol 8 (45) ◽  
pp. 18921-18927 ◽  
Author(s):  
G. Maiorano ◽  
E. Mele ◽  
M. C. Frassanito ◽  
E. Restini ◽  
A. Athanassiou ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Fiducial Markers ◽  
X Ray ◽  
X Ray Imaging

Low-dose phase-based X-ray imaging techniques for in situ soft tissue engineering assessments

Biomaterials ◽  
2016 ◽  
Vol 82 ◽  
pp. 151-167 ◽  
Author(s):  
Zohreh Izadifar ◽  
Ali Honaramooz ◽  
Sheldon Wiebe ◽  
George Belev ◽  
Xiongbiao Chen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Low Dose ◽  
Imaging Techniques ◽  
X Ray ◽  
X Ray Imaging ◽  
Soft Tissue Engineering

scholarly journals Data of low-dose phase-based X-ray imaging for in situ soft tissue engineering assessments

Data in Brief ◽  
2016 ◽  
Vol 6 ◽  
pp. 644-651 ◽  
Author(s):  
Zohreh Izadifar ◽  
Ali Honaramooz ◽  
Sheldon Wiebe ◽  
George Belev ◽  
Xiongbiao Chen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Low Dose ◽  
X Ray ◽  
X Ray Imaging ◽  
Soft Tissue Engineering

scholarly journals X-ray Phase-Contrast Computed Tomography for Soft Tissue Imaging at the Imaging and Medical Beamline (IMBL) of the Australian Synchrotron

2021 ◽  
Vol 11 (9) ◽  
pp. 4120
Author(s):  
Benedicta D. Arhatari ◽  
Andrew W. Stevenson ◽  
Brian Abbey ◽  
Yakov I. Nesterets ◽  
Anton Maksimenko ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Soft Tissue ◽  
Medical Imaging ◽  
Breast Imaging ◽  
Phase Contrast ◽  
Phase Retrieval ◽  
Short Exposure ◽  
X Rays ◽  
Ongoing Research ◽  
X Ray

The Imaging and Medical Beamline (IMBL) is a superconducting multipole wiggler-based beamline at the 3 GeV Australian Synchrotron operated by the Australian Nuclear Science and Technology Organisation (ANSTO). The beamline delivers hard X-rays in the 25–120 keV energy range and offers the potential for a range of biomedical X-ray applications, including radiotherapy and medical imaging experiments. One of the imaging modalities available at IMBL is propagation-based X-ray phase-contrast computed tomography (PCT). PCT produces superior results when imaging low-density materials such as soft tissue (e.g., breast mastectomies) and has the potential to be developed into a valuable medical imaging tool. We anticipate that PCT will be utilized for medical breast imaging in the near future with the advantage that it could provide better contrast than conventional X-ray absorption imaging. The unique properties of synchrotron X-ray sources such as high coherence, energy tunability, and high brightness are particularly well-suited for generating PCT data using very short exposure times on the order of less than 1 min. The coherence of synchrotron radiation allows for phase-contrast imaging with superior sensitivity to small differences in soft-tissue density. Here we also compare the results of PCT using two different detectors, as these unique source characteristics need to be complemented with a highly efficient detector. Moreover, the application of phase retrieval for PCT image reconstruction enables the use of noisier images, potentially significantly reducing the total dose received by patients during acquisition. This work is part of ongoing research into innovative tomographic methods aimed at the introduction of 3D X-ray medical imaging at the IMBL to improve the detection and diagnosis of breast cancer. Major progress in this area at the IMBL includes the characterization of a large number of mastectomy samples, both normal and cancerous, which have been scanned at clinically acceptable radiation dose levels and evaluated by expert radiologists with respect to both image quality and cancer diagnosis.

Quantifying the Spatial Variation of Lower-Limb Soft Tissue Artefact During Functional Activity Using MR Imaging and X-Ray Fluoroscopy

2009 ◽  
Author(s):  
Massoud Akbarshahi ◽  
Justin W. Fernandez ◽  
Anthony Schache ◽  
Richard Baker ◽  
Scott Banks ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Lower Limb ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
X Ray ◽  
Non Invasive ◽  
3D Motion Analysis ◽  
X Ray Imaging ◽  
Tissue Interface ◽  
Soft Tissue Artifact

Non-rigid movement of the soft tissue interface between skin-mounted markers and the underlying bones, also known as soft tissue artifact (STA), poses a major limitation to the non-invasive estimation of joint kinematics using three-dimensional (3D) motion analysis systems. Thorough knowledge of the nature of this non-rigid behavior is essential for development of compensation algorithms to enhance the accuracy of these systems. The studies in the literature aimed at quantifying STA have implemented invasive measurement methods such as bone pins [1] and external fixator devices [2], or have used subjects with pathological conditions [3]. In the present study, we integrated Magnetic Resonance (MR) and X-ray imaging techniques to evaluate the non-rigid behavior of the lower-limb soft tissue of healthy adults for a number of different functional tasks.

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