Anti-phagocytosis and tumor cell targeting micelles prepared from multifunctional cell membrane mimetic polymers

2016 ◽  
Vol 4 (32) ◽  
pp. 5464-5474 ◽  
Author(s):  
Hai-Tao Jiang ◽  
Kai Ding ◽  
Fan-Ning Meng ◽  
Li-Li Bao ◽  
Yu-Dong Chai ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Tumor Cell ◽  
Cell Targeting ◽  
Membrane Mimetic

“Stealthy bio-missile” kinds of micelles were fabricated for developing advanced anticancer formulations by cell membrane mimicking.

Folate Ligand Orientation Optimized during Cell Membrane Mimetic Micelle Formation for Enhanced Tumor Cell Targeting

Langmuir ◽  
2018 ◽  
Vol 35 (5) ◽  
pp. 1257-1265 ◽  
Author(s):  
Kai Ding ◽  
Rong Li ◽  
Yao Ma ◽  
Nan Li ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Tumor Cell ◽  
Micelle Formation ◽  
Cell Targeting ◽  
Membrane Mimetic ◽  
Ligand Orientation

A blood cell repelling and tumor cell capturing surface for high-purity enrichment of circulating tumor cells

2019 ◽  
Vol 7 (40) ◽  
pp. 6087-6098 ◽  
Author(s):  
Tong Li ◽  
Nan Li ◽  
Yao Ma ◽  
Yun-Jie Bai ◽  
Cheng-Mei Xing ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Red Blood Cell ◽  
High Purity ◽  
High Selectivity ◽  
Red Blood Cell Membrane ◽  
Membrane Mimetic

A red blood cell membrane mimetic surface decorated with FA and RGD ligands can efficiently capture tumor cells with high selectivity.

Folate-Conjugated Cell Membrane Mimetic Polymer Micelles for Tumor-Cell-Targeted Delivery of Doxorubicin

Langmuir ◽  
2018 ◽  
Vol 35 (2) ◽  
pp. 504-512 ◽  
Author(s):  
Qian Lu ◽  
Meijun Yi ◽  
Mengchen Zhang ◽  
Zhangyu Shi ◽  
Shiping Zhang
Keyword(s):  
Cell Membrane ◽  
Tumor Cell ◽  
Targeted Delivery ◽  
Polymer Micelles ◽  
Membrane Mimetic

scholarly journals RGD4C peptide mediates anti-p21Ras scFv entry into tumor cells and produces an inhibitory effect on the human colon cancer cell line SW480

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chen-Chen Huang ◽  
Fang-Rui Liu ◽  
Qiang Feng ◽  
Xin-Yan Pan ◽  
Shu-Ling Song ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Cell Membrane ◽  
Fusion Protein ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Fusion Proteins ◽  
Inhibitory Effect ◽  
Endosomal Escape ◽  
Antitumor Effects ◽  
Sw480 Cells

Abstract Background We prepared an anti-p21Ras scFv which could specifically bind with mutant and wild-type p21Ras. However, it cannot penetrate the cell membrane, which prevents it from binding to p21Ras in the cytoplasm. Here, the RGD4C peptide was used to mediate the scFv penetration into tumor cells and produce antitumor effects. Methods RGD4C-EGFP and RGD4C-p21Ras-scFv recombinant expression plasmids were constructed to express fusion proteins in E. coli, then the fusion proteins were purified with HisPur Ni-NTA. RGD4C-EGFP was used as reporter to test the factors affecting RGD4C penetration into tumor cell. The immunoreactivity of RGD4C-p21Ras-scFv toward p21Ras was identified by ELISA and western blotting. The ability of RGD4C-p21Ras-scFv to penetrate SW480 cells and colocalization with Ras protein was detected by immunocytochemistry and immunofluorescence. The antitumor activity of the RGD4C-p21Ras-scFv was assessed with the MTT, TUNEL, colony formation and cell migration assays. Chloroquine (CQ) was used an endosomal escape enhancing agent to enhance endosomal escape of RGD4C-scFv. Results RGD4C-p21Ras-scFv fusion protein were successfully expressed and purified. We found that the RGD4C fusion protein could penetrate into tumor cells, but the tumor cell entry of was time and concentration dependent. Endocytosis inhibitors and a low temperature inhibited RGD4C fusion protein endocytosis into cells. The change of the cell membrane potential did not affect penetrability. RGD4C-p21Ras-scFv could penetrate SW480 cells, effectively inhibit the growth, proliferation and migration of SW480 cells and promote this cells apoptosis. In addition, chloroquine (CQ) could increase endosomal escape and improve antitumor activity of RGD4C-scFv in SW480 cells. Conclusion The RGD4C peptide can mediate anti-p21Ras scFv entry into SW480 cells and produce an inhibitory effect, which indicates that RGD4C-p21Ras-scFv may be a potential therapeutic antibody for the treatment of ras-driven cancers.

4T1 cell membrane fragment reunited PAMAM polymer units disguised as tumor cell clusters for tumor homotypic targeting and anti-metastasis treatment

2021 ◽  
Author(s):  
Xiaochen Pei ◽  
Xiuhua Pan ◽  
Xiaoyi Xu ◽  
Xiang Xu ◽  
Haiqin Huang ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Tumor Cell ◽  
Membrane Fragment ◽  
Cell Clusters

Cell membrane-based nanoparticles have garnered increasing attention owing to their inherent biomimetic properties, such as homotypic targeting, prolong circulation, and immune escaping mechanisms.

PEG/RGD-modified magnetic polymeric liposomes for controlled drug release and tumor cell targeting

2012 ◽  
Vol 426 (1-2) ◽  
pp. 170-181 ◽  
Author(s):  
Wenya Su ◽  
Hanjie Wang ◽  
Sheng Wang ◽  
Zhenyu Liao ◽  
Shiyin Kang ◽  
...  
Keyword(s):  
Drug Release ◽  
Tumor Cell ◽  
Controlled Drug Release ◽  
Cell Targeting ◽  
Polymeric Liposomes

Tumor cell membrane-targeting pH-dependent electron donor-acceptor fluorescence systems with low background signals

Biomaterials ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. 2952-2960 ◽  
Author(s):  
Liang Han ◽  
Mingming Liu ◽  
Deyong Ye ◽  
Ning Zhang ◽  
Ed Lim ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Tumor Cell ◽  
Electron Donor ◽  
Membrane Targeting ◽  
Tumor Cell Membrane ◽  
Low Background ◽  
Donor Acceptor ◽  
Ph Dependent

scholarly journals Antifouling and pH-Responsive Poly(Carboxybetaine)-Based Nanoparticles for Tumor Cell Targeting

2019 ◽  
Vol 7 ◽  
Author(s):  
Feng Ding ◽  
Shuang Yang ◽  
Zhiliang Gao ◽  
Jianman Guo ◽  
Peiyu Zhang ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Targeting ◽  
Ph Responsive
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