A blood cell repelling and tumor cell capturing surface for high-purity enrichment of circulating tumor cells

2019 ◽  
Vol 7 (40) ◽  
pp. 6087-6098 ◽  
Author(s):  
Tong Li ◽  
Nan Li ◽  
Yao Ma ◽  
Yun-Jie Bai ◽  
Cheng-Mei Xing ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Red Blood Cell ◽  
High Purity ◽  
High Selectivity ◽  
Red Blood Cell Membrane ◽  
Membrane Mimetic

A red blood cell membrane mimetic surface decorated with FA and RGD ligands can efficiently capture tumor cells with high selectivity.

scholarly journals Red Blood Cell Membrane-Camouflaged Tedizolid Phosphate-Loaded PLGA Nanoparticles for Bacterial-Infection Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 99
Author(s):  
Xinyi Wu ◽  
Yichen Li ◽  
Faisal Raza ◽  
Xuerui Wang ◽  
Shulei Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Cell Membrane ◽  
Blood Cell ◽  
Sustained Release ◽  
Delivery System ◽  
Red Blood Cell ◽  
Multiple Drug Resistance ◽  
Plga Nanoparticles ◽  
Multiple Drug ◽  
Red Blood Cell Membrane

Multiple drug resistance (MDR) in bacterial infections is developed with the abuse of antibiotics, posing a severe threat to global health. Tedizolid phosphate (TR-701) is an efficient prodrug of tedizolid (TR-700) against gram-positive bacteria, including methicillin-sensitive staphylococcus aureus (MSSA) and methicillin-resistant staphylococcus aureus (MRSA). Herein, a novel drug delivery system: Red blood cell membrane (RBCM) coated TR-701-loaded polylactic acid-glycolic acid copolymer (PLGA) nanoparticles (RBCM-PLGA-TR-701NPs, RPTR-701Ns) was proposed. The RPTR-701Ns possessed a double-layer core-shell structure with 192.50 ± 5.85 nm in size, an average encapsulation efficiency of 36.63% and a 48 h-sustained release in vitro. Superior bio-compatibility was confirmed with red blood cells (RBCs) and HEK 293 cells. Due to the RBCM coating, RPTR-701Ns on one hand significantly reduced phagocytosis by RAW 264.7 cells as compared to PTR-701Ns, showing an immune escape effect. On the other hand, RPTR-701Ns had an advanced exotoxins neutralization ability, which helped reduce the damage of MRSA exotoxins to RBCs by 17.13%. Furthermore, excellent in vivo bacteria elimination and promoted wound healing were observed of RPTR-701Ns with a MRSA-infected mice model without causing toxicity. In summary, the novel delivery system provides a synergistic antibacterial treatment of both sustained release and bacterial toxins absorption, facilitating the incorporation of TR-701 into modern nanotechnology.

scholarly journals Direct Measurement of the Area Expansion and Shear Moduli of the Human Red Blood Cell Membrane Skeleton

2001 ◽  
Vol 81 (1) ◽  
pp. 43-56 ◽  
Author(s):  
Guillaume Lenormand ◽  
Sylvie Hénon ◽  
Alain Richert ◽  
Jacqueline Siméon ◽  
François Gallet
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Direct Measurement ◽  
Red Blood Cell ◽  
Membrane Skeleton ◽  
Shear Moduli ◽  
Red Blood Cell Membrane ◽  
Area Expansion

Interaction of Different Extracts ofPrimula heterochromaStapf. with Red Blood Cell Membrane Lipids and Proteins: Antioxidant and Antihemolytic Effects

2012 ◽  
Vol 9 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Seyed Mohammad Nabavi ◽  
Seyed Fazel Nabavi ◽  
William N. Setzer ◽  
Heshmatollah Alinezhad ◽  
Mahboobeh Zare ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Membrane Lipids ◽  
Red Blood Cell Membrane
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