Tetraphenylethylene-based fluorescent coordination polymers for drug delivery

2016 ◽  
Vol 4 (24) ◽  
pp. 4263-4266 ◽  
Author(s):  
Lei Wang ◽  
Weiqi Wang ◽  
Zhigang Xie
Keyword(s):  
Drug Delivery ◽  
Coordination Polymers ◽  
Drug Loading ◽  
Enhanced Luminescence ◽  
Nanoscale Coordination Polymers

Porous nanoscale coordination polymers possess morphology-dependent enhanced luminescence and are used for drug loading and delivery.

Redox-Sensitive Nanoscale Coordination Polymers for Drug Delivery and Cancer Theranostics

2017 ◽  
Vol 9 (28) ◽  
pp. 23555-23563 ◽  
Author(s):  
Jiayue Zhao ◽  
Yu Yang ◽  
Xiao Han ◽  
Chao Liang ◽  
Jingjing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymers ◽  
Cancer Theranostics ◽  
Nanoscale Coordination Polymers

Nanoscale Coordination Polymers for Platinum-Based Anticancer Drug Delivery

2008 ◽  
Vol 130 (35) ◽  
pp. 11584-11585 ◽  
Author(s):  
William J. Rieter ◽  
Kimberly M. Pott ◽  
Kathryn M. L. Taylor ◽  
Wenbin Lin
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Coordination Polymers ◽  
Anticancer Drug Delivery ◽  
Nanoscale Coordination Polymers

scholarly journals pH‐Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy

2019 ◽  
Vol 29 (51) ◽  
pp. 1908180 ◽  
Author(s):  
Jingjing Liu ◽  
Hairong Wang ◽  
Xuan Yi ◽  
Yu Chao ◽  
Yuehao Geng ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Nanoscale Coordination Polymers

scholarly journals Versatile iron–catechol-based nanoscale coordination polymers with antiretroviral ligand functionalization and their use as efficient carriers in HIV/AIDS therapy

2019 ◽  
Vol 7 (1) ◽  
pp. 178-186 ◽  
Author(s):  
Rubén Solórzano ◽  
Olivia Tort ◽  
Javier García-Pardo ◽  
Tuixent Escribà ◽  
Julia Lorenzo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Coordination Polymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Aids Therapy ◽  
Iron Based ◽  
Novel Drug ◽  
Nanoscale Coordination Polymers ◽  
Hiv Aids

Iron-based nanoscale coordination polymers as novel drug delivery systems for efficient HIV/AIDS therapy.

pH-Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy

2017 ◽  
Vol 27 (44) ◽  
pp. 1703832 ◽  
Author(s):  
Jingjing Liu ◽  
Hairong Wang ◽  
Xuan Yi ◽  
Yu Chao ◽  
Yuehao Geng ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Nanoscale Coordination Polymers

An Overview of Second Generation Nanoparticles− Nanostructure Lipid Carrier Drug Delivery System

2020 ◽  
Vol 13 (6) ◽  
pp. 5181-5189
Author(s):  
Prabhat Kumar Sahoo ◽  
Neha S.L ◽  
Arzoo Pannu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Second Generation ◽  
Drug Loading ◽  
Scale Up ◽  
Delivery Systems ◽  
Route Of Administration ◽  
Random Structure ◽  
Stability Parameters

Lipids are used as vehicles for the preparation of various formulations prescribed for administrations, including emulsions, ointments, suspension, tablets, and suppositories. The first parental nano-emulsion was discovered from the 1950s when it was added to the intravenous administration of lipid and lipid-soluble substances. Lipid-based drug delivery systems are important nowadays. Solid nanoparticles (SLN) and Nanostructured lipid carriers (NLC) are very proficient due to the ease of production process, scale-up capability, bio-compatibility, the biodegradability of formulation components and other specific features of the proposed route. The administration or nature of the materials must be loaded into these delivery systems. The main objectives of this review are to discuss an overview of second-generation nanoparticles, their limitations, structures, and route of administration, with emphasis on the effectiveness of such formulations. NLC is the second generation of lipid nanoparticles having a structure like nanoemulsion. The first generation of nanoparticles was SLN. The difference between both of them is at its core. Both of them are a colloidal carrier in submicron size in the range of 40-1000 nm. NLC is the most promising novel drug delivery system over the SLN due to solving the problem of drug loading and drug crystallinity. Solid and liquid lipids combination in NLC formation, improve its quality as compare to SLN. NLC has three types of structures: random, amorphous, and multiple. The random structure containing solid-liquid lipids and consisting crystal and the liquid lipid irregular in shape; thereby enhance the ability of the lipid layer to pass through the membrane. The second is the amorphous structure. It is less crystalline in nature and can prevent the leakage of the loaded drug. The third type is multiple structures, which have higher liquid lipid concentrations than other types. The excipients used to form the NLC are bio-compatible, biodegradable and non-irritating, most of which can be detected using GRAS. NLC is a promising delivery system to deliver the drug through pulmonary, ocular, CNS, and oral route of administration. Various methods of preparation and composition of NLC influence its stability Parameters. In recent years at the educational level, the potential of NLC as a delivery mechanism targeting various organs has been investigated in detail.

Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery

2019 ◽  
Vol 26 (14) ◽  
pp. 2502-2513 ◽  
Author(s):  
Md. Iqbal Hassan Khan ◽  
Xingye An ◽  
Lei Dai ◽  
Hailong Li ◽  
Avik Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Release Mechanism ◽  
Innovative Drug ◽  
Pharmaceutical Excipients ◽  
Weight Variation

The development of innovative drug delivery systems, versatile to different drug characteristics with better effectiveness and safety, has always been in high demand. Chitosan, an aminopolysaccharide, derived from natural chitin biomass, has received much attention as one of the emerging pharmaceutical excipients and drug delivery entities. Chitosan and its derivatives can be used for direct compression tablets, as disintegrant for controlled release or for improving dissolution. Chitosan has been reported for use in drug delivery system to produce drugs with enhanced muco-adhesiveness, permeation, absorption and bioavailability. Due to filmogenic and ionic properties of chitosan and its derivative(s), drug release mechanism using microsphere technology in hydrogel formulation is particularly relevant to pharmaceutical product development. This review highlights the suitability and future of chitosan in drug delivery with special attention to drug loading and release from chitosan based hydrogels. Extensive studies on the favorable non-toxicity, biocompatibility, biodegradability, solubility and molecular weight variation have made this polymer an attractive candidate for developing novel drug delivery systems including various advanced therapeutic applications such as gene delivery, DNA based drugs, organ specific drug carrier, cancer drug carrier, etc.

Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration

2020 ◽  
Vol 27 (22) ◽  
pp. 3623-3656 ◽  
Author(s):  
Bruno Fonseca-Santos ◽  
Patrícia Bento Silva ◽  
Roberta Balansin Rigon ◽  
Mariana Rillo Sato ◽  
Marlus Chorilli
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Drug Release ◽  
Drug Loading ◽  
Average Particle Size ◽  
Delivery Systems ◽  
Average Particle ◽  
Minor Importance ◽  
Routes Of Administration ◽  
Non Invasive

Colloidal carriers diverge depending on their composition, ability to incorporate drugs and applicability, but the common feature is the small average particle size. Among the carriers with the potential nanostructured drug delivery application there are SLN and NLC. These nanostructured systems consist of complex lipids and highly purified mixtures of glycerides having varying particle size. Also, these systems have shown physical stability, protection capacity of unstable drugs, release control ability, excellent tolerability, possibility of vectorization, and no reported production problems related to large-scale. Several production procedures can be applied to achieve high association efficiency between the bioactive and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. The whole set of unique advantages such as enhanced drug loading capacity, prevention of drug expulsion, leads to more flexibility for modulation of drug release and makes Lipid-based nanocarriers (LNCs) versatile delivery system for various routes of administration. The route of administration has a significant impact on the therapeutic outcome of a drug. Thus, the non-invasive routes, which were of minor importance as parts of drug delivery in the past, have assumed added importance drugs, proteins, peptides and biopharmaceuticals drug delivery and these include nasal, buccal, vaginal and transdermal routes. The objective of this paper is to present the state of the art concerning the application of the lipid nanocarriers designated for non-invasive routes of administration. In this manner, this review presents an innovative technological platform to develop nanostructured delivery systems with great versatility of application in non-invasive routes of administration and targeting drug release.

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