scholarly journals pH‐Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy

2019 ◽  
Vol 29 (51) ◽  
pp. 1908180 ◽  
Author(s):  
Jingjing Liu ◽  
Hairong Wang ◽  
Xuan Yi ◽  
Yu Chao ◽  
Yuehao Geng ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Nanoscale Coordination Polymers

pH-Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy

2017 ◽  
Vol 27 (44) ◽  
pp. 1703832 ◽  
Author(s):  
Jingjing Liu ◽  
Hairong Wang ◽  
Xuan Yi ◽  
Yu Chao ◽  
Yuehao Geng ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Nanoscale Coordination Polymers

Tetraphenylethylene-based fluorescent coordination polymers for drug delivery

2016 ◽  
Vol 4 (24) ◽  
pp. 4263-4266 ◽  
Author(s):  
Lei Wang ◽  
Weiqi Wang ◽  
Zhigang Xie
Keyword(s):  
Drug Delivery ◽  
Coordination Polymers ◽  
Drug Loading ◽  
Enhanced Luminescence ◽  
Nanoscale Coordination Polymers

Porous nanoscale coordination polymers possess morphology-dependent enhanced luminescence and are used for drug loading and delivery.

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

Synthesis of Nanoscale Coordination Polymers in Femtoliter Reactors on Surfaces

ACS Nano ◽  
2016 ◽  
Vol 10 (3) ◽  
pp. 3206-3213 ◽  
Author(s):  
Mireia Guardingo ◽  
Pablo González-Monje ◽  
Fernando Novio ◽  
Elena Bellido ◽  
Félix Busqué ◽  
...  
Keyword(s):  
Coordination Polymers ◽  
Nanoscale Coordination Polymers

scholarly journals ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 29986-29996
Author(s):  
Xiuxiu Qi ◽  
Hongmei Yan ◽  
Yingxue Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Core Shell ◽  
Assembly Process ◽  
Block Polymer ◽  
Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

scholarly journals Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

2021 ◽  
Vol 9 ◽  
Author(s):  
Enping Chen ◽  
Ting Wang ◽  
Junmei Zhang ◽  
Xiang Zhou ◽  
Yafan Niu ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Combination Regimen ◽  
Drug Efflux ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Chemotherapeutic Drug ◽  
Mitochondrial Targeting ◽  
Ph Responsive ◽  
Mcf 7

Multidrug resistance (MDR) is one of the leading causes of the failure of cancer chemotherapy and mainly attributed to the overexpression of drug efflux transporters in cancer cells, which is dependent on adenosine triphosphate (ATP). To overcome this phenomenon, herein, a mitochondrial-directed pH-sensitive polyvinyl alcohol (PVA) nanogel incorporating the hexokinase inhibitor lonidamine (LND) and the chemotherapeutic drug paclitaxel (PTX) was developed to restore the activity of PTX and synergistically treat drug-resistant tumors. The introduction of 2-dimethylaminoethanethiol (DMA) moiety into the nanogels not only promoted the drug loading capacity but also enabled the lysosomal escape of the nanogels. The subsequent mitochondrial targeting facilitated the accumulation and acid-triggered payload release in the mitochondria. The released LND can destroy the mitochondria by exhausting the mitochondrial membrane potential (MMP), generating reactive oxygen species (ROS) and restraining the energy supply, resulting in apoptosis and susceptibility of the MCF-7/MDR cells to PTX. Hence, the nanogel-enabled combination regimen of LND and PTX showed a boosted anti-tumor efficacy in MCF-7/MDR cells. These mitochondrial-directed pH-sensitive PVA nanogels incorporating both PTX and LND represent a new nanoplatform for MDR reversal and enhanced therapeutic efficacy.

scholarly journals Halochromic coordination polymers based on a triarylmethane dye for reversible detection of acids

2017 ◽  
Vol 46 (2) ◽  
pp. 465-470 ◽  
Author(s):  
Marina S. Zavakhina ◽  
Irina V. Yushina ◽  
Denis G. Samsonenko ◽  
Danil N. Dybtsev ◽  
Vladimir P. Fedin ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
Coordination Polymers ◽  
Ph Sensitive ◽  
Triarylmethane Dye

A pH-sensitive coordination polymer reversibly changes its color in air or acidic atmosphere.

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